Diabetology of Pregnancy

Provides a comprehensive overview of the scientific and clinical characteristics of gestational diabetes as well as type 1 and type 2 diabetes mellitus during pregnancy. The role of the placenta as a fetal organ at the interface between mother and fetus is also covered.

Trends identified when estimating global prevalence suggest the world is facing a pandemic of diabetes mellitus. Consequently a rapid increase in the incidence of gestational diabetes mellitus is expected. This volume provides a comprehensive yet concise overview of the scientific and clinical characteristics of gestational diabetes as well as type 1 and type 2 diabetes mellitus during pregnancy. Throughout the book the authors adopt a multidisciplinary approach and cover aspects such as etiology, physiology, molecular biology and genetics, immunology, pathogenesis, diagnosis, treatment and management, pathology and evidence-based medicine. The role of the placenta as a fetal organ at the interface between mother and fetus is covered in depth. Basic scientists and medical researchers will find several chapters reviewing the basis of our understanding of many aspects of the disease ranging from maternal endocrinology to fuel-mediated functional teratogenesis.

Preface		ix
Epidemiology of Pregestational and Gestational Diabetes		1	(8)
Pavlic-Renar, I.
Metelko, Z.
Fuel-Mediated `Functional Teratogenesis' and Primary Prevention		9	(9)
Plagemann, A.
Endocrine Changes in Diabetic Pregnancy		18	(16)
Kautzky-Willer, A.
Bancher-Todesca, D.
Metabolic Changes in Diabetic Pregnancy		34	(12)
Herrera, E.
Leptin in the Diabetic Pregnancy		46	(12)
Hauguel-de Mouzon, S.
Lepercq, J.
Catalano, P.
Maternal Diabetes and Embryonic Development		58	(14)
De Hertogh, R.
Normal and Abnormal Fetal Growth		72	(11)
Cetin, I.
Radaelli, T.
Effect of Nutrition on Fetal Development: A View on the Pancreatic β-Cells		83	(11)
Blondeau, B.
Breant, B.
The Human Placenta in Diabetes		94	(16)
Desoye, G.
Kaufmann, P.
Vasculogenesis and Angiogenesis in the Diabetic Placenta		110	(17)
Leach, L.
Mayhew, T.M.
Morphological Findings in Infants and Placentas of Diabetic Mothers		127	(17)
Kos, M.
Vogel, M.
Principles of Evidence-Based Medicine. The Lesson for Diabetic Pregnancy		144	(9)
Pieber, T.R.
The Graz Approach to Diabetes in Pregnancy		153	(8)
Weiss, P.A.M.
Desoye, G.
Clinical Management of Pregnancies Complicated with Type 1/Type 2 Diabetes mellitus		161	(13)
Djelmis, J.
Nutritional Management of Diabetes in Pregnancy		174	(21)
Dornhorst, A.
Frost, G.
Diabetes-Related Antibodies and Pregnancy		195	(11)
Corcoy, R.
Mauricio, D.
de Leiva, A.
Insulin and Oral Hypoglycemic Agents in Pregnancy		206	(8)
Metelko, Z.
Pavlic-Renar, I.
Continuous Glucose Monitoring for the Evaluation and Improved Treatment Adjustment in Gravid Women with Diabetic Pregnancy		214	(8)
Hod, M.
Yogev, Y.
Fetal Hypoxia and Its Monitoring in Pregestational Diabetic Pregnancies		222	(8)
Teramo, K.A.
Hiilesmaa, V.K.
Ultrasonic Surveillance of the Diabetic Fetus		230	(24)
Ivanisevic, M.
Diabetic Pregnancy: Maternal Metabolic and Microvascular Complications in Type 1 Diabetes mellitus		254	(17)
Pearson, D.W.M.
Pre-Eclampsia in Women with Type 1 Diabetes		271	(7)
Mathiesen, E.R.
Damm, P.
Management of Delivery		278	(10)
Miller, V.A.
Gillmer, M.D.G.
Offspring of Diabetic Pregnancy		288	(22)
Persson, B.
Eriksson, U.J.
Hanson, U.
Long-Term Consequences of Gestational Diabetes mellitus		310	(10)
Lauenborg, J.
Mathiesen, E.R.
Damm, P.
Author Index		320	(1)
Subject Index		321