Goodman and Gilman's the Pharmacological Basis of Therapeutics 12th Revised edition, Set 2

A full-color book with 200 illustrations describes the actions and uses of the drugs essential to preventing, diagnosing and treating disease and comes with DVD bank of images and animations.

The landmark text in medical pharmacology is now in full color

More than 1,000,000 copies sold since the first edition!

The most universally respected and read medical textbook in all of pharmacology, Goodman and Gilman’s represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology.Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease.

Features

• NEW full-color presentation
• NEW DVD with image bank and the outstanding pedagogical animations from Goodman & Gilman OnLine
• MORE illustrations than ever before, with approximately 200 additional figures showing key principles and actions of specific pathways and therapeutic agents
• NEW text design to speed navigation

Gold-standard content (condensed):
SECTION I: GENERAL PRINCIPLES,SECTION II: DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES,SECTION III: DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM,SECTION IV: AUTACOIDS: DRUG THERAPY OF INFLAMMATION,SECTION V: DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION,SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION,SECTION VII: CHEMOTHERAPY OF PARASITIC INFECTIONS,SECTION VIII: CHEMOTHERAPY OF MICROBIAL DISEASES,SECTION IX: CHEMOTHERAPY OF NEOPLASTIC DISEASES,SECTION X: DRUGS USED FOR IMMUNOMODULATION,SECTION XI: DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS,SECTION XII: HORMONES AND HORMONE ANTAGONISTS,SECTION XIII: DERMATOLOGY,SECTION XIV: OPHTHALMOLOGY,SECTION XV: TOXICOLOGY,APPENDICES:I. Principles of Prescription Order Writing and Patient Compliance,II. Design and Optimization of Dosage Regimens; Pharmacokinetic Data

The landmark text in medical pharmacology is now in full color Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance...This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service The most universally respected and read medical text in all of pharmacology, Goodman & Gilman's The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman's careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering: General Principles Neuropharmacology Modulation of Cardiovascular Function Inflammation, Immunomodulation, and Hematopoiesis Endocrine Pharmacology Gastrointestinal Pharmacology Chemotherapy of Infectious Disease Chemotherapy of Neoplastic Diseases Special Systems Pharmacology More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

Contributors		xi
Preface		xvii
Preface to the First Edition		xix
Acknowledgements		xxi
SECTION I General Principles		1	(168)
1 Drug Invention and the Pharmaceutical Industry		3	(14)
Suzanne M. Rivera
Alfred Goodman Gilman
2 Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination		17	(24)
Iain L. O. Buxton
Leslie Z. Benet
3 Pharmacody namics: Molecular Mechanisms of Drug Action		41	(32)
Donald K. Blumenthal
James C. Garrison
4 Drug Toxicity and Poisoning		73	(16)
Kevin C. Osterhoudt
Trevor M. Penning
5 Membrane Transporters and Drug Response		89	(34)
Kathleen M. Giacomini
Yuichi Sugiyama
6 Drug Metabolism		123	(22)
Frank J. Gonzalez
Michael Coughtrie
Robert H. Tukey
7 Pharmacogenetics		145	(24)
Mary V. Relling
Kathleen M. Giacomini
SECTION II Neuropharmacology		169	(500)
8 Neurotransmission: The Autonomic and Somatic Motor Nervous Systems		171	(48)
Thomas C. Westfall
David P. Westfall
9 Muscarinic Receptor Agonists and Antagonists		219	(20)
Joan Heller Brown
Nora Laiken
10 Anticholinesterase Agents		239	(16)
Palmer Taylor
11 Agents Acting at the Neuromuscular Junction and Autonomic Ganglia		255	(22)
Ryan E. Hibbs
Alexander C. Zambon
12 Adrenergic Agonists and Antagonists		277	(58)
Thomas C. Westfall
David P. Westfall
13 5-Hydroxytryptamine (Serotonin) and Dopamine		335	(28)
Elaine Sanders-Bush
Lisa Hazelwood
14 Neurotransmission and the Central Nervous System		363	(34)
Perry B. Molinoff
15 Drug Therapy of Depression and Anxiety Disorders		397	(20)
James M. O'Donnell
Richard C. Shelton
16 Pharmacotherapy of Psychosis and Mania		417	(40)
Jonathan M. Meyer
17 Hypnotics and Sedatives		457	(24)
S. John Mihic
R. Adron Harris
18 Opioids, Analgesia, and Pain Management		481	(46)
Tony L. Yaksh
Mark S. Wallace
19 General Anesthetics and Therapeutic Gases		527	(38)
Piyush M. Patel
Hemal H. Patel
David M. Roth
20 Local Anesthetics		565	(18)
William A. Catterall
Kenneth MacKie
21 Pharmacotherapy of the Epilepsies		583	(26)
James O. McNamara
22 Treatment of Central Nervous System Degenerative Disorders		609	(20)
David G. Standaert
Erik D. Roberson
23 Ethanol and Methanol		629	(20)
Marc A. Schuckit
24 Drug Addiction		649	(20)
Charles P. O'Brien
SECTION III Modulation of Cardiovascular Function		669	(240)
25 Regulation of Renal Function and Vascular Volume		671	(50)
Robert F. Reilly
Edwin K. Jackson
26 Renin and Angiotensin		721	(24)
Randa Hilal-Dandan
27 Treatment of Myocardial Ischemia and Hypertension		745	(44)
Thomas Michel
Brian B. Hoffman
28 Pharmacotherapy of Congestive Heart Failure		789	(26)
Bradley A. Maron
Thomas P. Rocco
29 Anti-Arrhythmic Drugs		815	(34)
Kevin J. Sampson
Robert S. Kass
30 Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs		849	(28)
Jeffrey I. Weitz
31 Drug Therapy for Hypercholesterolemia and Dyslipidemia		877	(32)
Thomas P. Bersot
SECTION IV Inflammation, Immunomodulation, and Hematopoiesis		909	(192)
32 Histamine, Bradykinin, and Their Antagonists		911	(26)
Randal A. Skidgel
Allen P. Kaplan
Ervin G. Erdos
33 Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor		937	(22)
Emer M. Smyth
Tilo Grosser
Garret A. FitzGerald
34 Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout		959	(46)
Tilo Grosser
Emer M. Smyth
Garret A. FitzGerald
35 Immunosuppressants, Tolerogens, and Immunostimulants		1005	(26)
Alan M. Krensky
William M. Bennett
Flavio Vincenti
36 Pulmonary Pharmacology		1031	(36)
Peter J. Barnes
37 Hematopoietic Agents: Growth Factors, Minerals, and Vitamins		1067	(34)
Kenneth Kaushansky
Thomas J. Kipps
SECTION V Hormones and Hormone Antagonists		1101	(206)
38 Introduction to Endocrinology: The Hypothalamic-Pituitary Axis		1103	(26)
Keith L. Parker
Bernard P. Schimmer
39 Thyroid and Anti-Thyroid Drugs		1129	(34)
Gregory A. Brent
Ronald J. Koenig
40 Estrogens and Progestins		1163	(32)
Ellis R. Levin
Stephen R. Hammes
41 Androgens		1195	(14)
Peter J. Snyder
42 ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex		1209	(28)
Bernard P. Schimmer
John W. Funder
43 Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia		1237	(38)
Alvin C. Powers
David D'Alessio
44 Agents Affecting Mineral Ion Homeostasis and Bone Turnover		1275	(32)
Peter A. Friedman
SECTION VI Drugs Affecting Gastrointestinal Function		1307	(56)
45 Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease		1309	(14)
John L. Wallace
Keith A. Sharkey
46 Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease		1323	(28)
Keith A. Sharkey
John L. Wallace
47 Pharmacotherapy of Inflammatory Bowel Disease		1351	(12)
John L. Wallace
Keith A. Sharkey
SECTION VII Chemotherapy of Microbial Diseases		1363	(302)
48 General Principles of Antimicrobial Therapy		1365	(18)
Tawanda Gumbo
49 Chemotherapy of Malaria		1383	(36)
Joseph M. Vinetz
Jerome Clain
Viengngeun Bounkeua
Richard T. Eastman
David Fidock
50 Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections		1419	(24)
Margaret A. Phillips
Samuel L. Stanley, Jr.
51 Chemotherapy of Helminth Infections		1443	(20)
James McCarthy
Alex Loukas
Peter J. Hotez
52 Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections		1463	(14)
William A. Petri, Jr.
53 Penicillins, Cephalosporins, and Other β-Lactam Antibiotics		1477	(28)
William A. Petri, Jr.
54 Aminoglycosides		1505	(16)
Conan MacDougall
Henry F. Chambers
55 Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents		1521	(28)
Conan MacDougall
Henry F. Chambers
56 Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy		1549	(22)
Tawanda Gumbo
57 Antifungal Agents		1571	(22)
John E. Bennett
58 Antiviral Agents (Nonretroviral)		1593	(30)
Edward P. Acosta
Charles Flexner
59 Antiretroviral Agents and Treatment of HIV Infection		1623	(42)
Charles Flexner
SECTION VIII Chemotherapy of Neoplastic Diseases		1665	(106)
60 General Principles of Cancer Chemotherapy		1667	(10)
Bruce A. Chabner
61 Cytotoxic Agents		1677	(54)
Bruce A. Chabner
Joseph Bertino
James Cleary
Taylor Ortiz
Andrew Lane
Jeffrey G. Supko
David Ryan
62 Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines		1731	(24)
Bruce A. Chabner
Jeffrey Barnes
Joel Neal
Erin Olson
Hamza Mujagic
Lecia Sequist
Wynham Wilson
Dan L. Longo
Constantine Mitsiades
Paul Richardson
63 Natural Products in Cancer Chemotherapy: Hormones and Related Agents		1755	(16)
Beverly Moy
Richard J. Lee
Matthew Smith
SECTION IX Special Systems Pharmacology		1771	(108)
64 Ocular Pharmacology		1773	(30)
Jeffrey D. Henderer
Christopher J. Rapuano
65 Dermatological Pharmacology		1803	(30)
Craig Burkhart
Dean Morrell
Lowell Goldsmith
66 Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders		1833	(20)
Bernard P. Schimmer
Keith L. Parker
67 Environmental Toxicology; Carcinogens and Heavy Metals		1853	(26)
Michael C. Byrns
Trevor M. Penning
Appendices
I Principles of Prescription Order Writing and Patient Compliance		1879	(12)
Iain L. O. Buxton
II Design and Optimization of Dosage Regimens: Pharmacokinetic Data		1891	(100)
Kenneth E. Thummel
Danny D. Shen
Nina Isoherranen
Index		1991

Editor: Laurence L. Brunton, PhD Professor of Pharmacology and Medicine University of California San Diego School of Medicine La Jolla, CA Associate Editors: Bruce A. Chabner, MD Clinical Director MDF Cancer Center Professor of Medicine Harvard Medical School Boston, MA Bjorn Christian Knollmann, MD, PhD Associate Professor of Medicine and Pharmacology Oates Institute for Experimental Therapeutics Vanderbilt University School of Medicine Division of Clinical Pharmacology Nashville, TN