Harrison's Infectious Diseases

Featuring the chapters on infectious diseases that appear in Harrison's Principles of Internal Medicine, 17e, this expert clinical companion delivers the latest knowledge in the field, backed by the scientific rigor and reliability that have defined Harrison's. Inside you'll find coverage that reflects the expertise of renowned editors and contributors---presented in a stand-alone format that makes it ideal for the classroom, the wards, or exam/certification preparation.

The authority of Harrison's in a handy, full-color paperback devoted exclusively to Infectious Diseases

Featuring the chapters on Infectious Diseases that appear in the landmark Harrison's Principles of Internal Medicine, 17e, this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliabilty that has defined Harrison's.

You'll find coverage that reflects the expertise of renowned editors and contributors -- presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, Harrison's Infectious Diseases is a must for students and clinicians alike.

Harrison's Infectious Diseases delivers:

• All the relevant chapters from Harrison's Principles of Internal Medicine, 17e
• 6 chapters from the acclaimed Harrison's DVD
• Content updates and new developments
• Reference updates
• 100+ questions and answers from Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 17e
• An update on H1N1

Everything you would expect from Harrison's tailored to your specialty
Condensed Table of Contents: Introduction to Infectious Diseases; Fever and Approach to the Febrile Patient; Infections in Organ Systems; Bacterial Infections; Viral Infections, Prion Diseases; Fungal and Algal Infections; Protozoal and Helminthic Infections

The Harrison’s specialty series is written by the same world-renowned author team who brought you Harrison’s Principles of Internal Medicine, 17e:
Anthony S. Fauci, MD; Eugene Braunwald, MD; Dennis L. Kasper, MD; Stephen L. Hauser, MD; Dan L. Longo, MD; J. Larry Jameson, MD, PhD; Joseph Loscalzo, MD, PhD

This authority of Harrison's in a handy, full-color paperback devoted exclusively to Infectious Diseases. Featuring the chapters on Infectious Diseases that appear in the landmark "Harrison's Principles of Internal Medicine, 17/e", this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliability that have defined Harrison's. You'll find coverage that reflects the expertise of renowned editors and contributors - presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, "Harrison's Infectious Diseases" is a must for students and clinicians alike. "Harrison's Infectious Diseases" delivers: current, complete coverage of essential infectious diseases topics, including infections in organ systems, bacterial infections, viral infections, prion diseases, fungal and algal infections, and protozoal and helminthic infections; 100+ high-yield Q&A drawn from "Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 17/e"; 6 complete chapters in print format from the Harrison's DVD; 127 chapters written by experts who have made significant contributions to knowledge in their fields; references and other material that have been updated since the publication of "HPIM, 17/e"; integration of pathophysiology with clinical management topics in each of the disease-oriented chapters; helpful appendix of laboratory values of clinical importance; and, everything you would expect from Harrison's tailored to your specialty. The Harrison's specialty series is written by the same world-renowned author team who brought you "Harrison's Principles of Internal Medicine, 17/e": Anthony S. Fauci, MD; Eugene Braunwald, MD; Dennis L. Kasper, MD; Stephen L. Hauser, MD; Dan L. Longo, MD; J. Larry Jameson, MD, PhD; and, Joseph Loscalzo, MD, PhD.

Contributors		xi
Preface		xvii
SECTION I INTRODUCTION TO INFECTIOUS DISEASES
1 Introduction to Infectious Diseases: Host-Pathogen Interactions		2	(7)
Lawrence C. Madoff
Dennis L. Kasper
2 Molecular Mechanisms of Microbial Pathogenesis		9	(11)
Gerald B. Pier
3 Immunizaation Principles and Vaccine Use		20	(23)
Gerald T. Keusch
Kenneth J. Bart
Mark Miller
4 Health Advice for International Travel		43	(11)
Jay S. Keystone
Phyllis E. Kozarsky
5 Laboratory Diagnosis of Infectious Diseases		54	(12)
Alexander J. McAdam
Andrew B. Onderdonk
6 Microbial Bioterrorism		66	(16)
H. Clifford Lane
Anthony S. Fauci
SECTION II FEVER AND APPROACH TO THE FEBRILE PATIENT
7 Fever and Hyperthermia		82	(5)
Charles A. Dinarello
Reuven Porat
8 Fever and Rase		87	(13)
Elaine T. Kaye
Kenneth M. Kaye
9 Fever of Unkonwn Origin		100	(8)
Jeffrey A. Gelfand
Michael V. Callahan
10 Atlas of Rashes Associated with Fever		108	(10)
Kenneth M. Kaye
Elaine T. Kaye
11 Infections in Patients with Cancer		118	(12)
Robert Finberg
12 Infections in Transplant Recipients		130	(14)
Robert Finberg
Joyce Fingeroth
13 Health Care---Associated Infections		144	(9)
Robert A. Weinstein
14 Approach to the Acutely Ill Infected Febrile Patient		153	(9)
Tamar F. Barlam
Dennis L. Kasper
15 Severe Sepsis and Septic Shock		162	(12)
Robert S. Munford
SECTION III INFECTIONS IN ORGAN SYSTEMS
16 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections		174	(14)
Michael A. Rubin
Ralph Gonzales
Merle A. Sande
17 Pneumonia		188	(14)
Lionel A. Mandell
Richard Wunderink
18 Bronchiectasis and Lung Abscess		202	(4)
Gregory Tino
Steven E. Weinberger
19 Infective Endocarditis		206	(14)
Adolf W. Karchmer
20 Pericardial Disease		220	(10)
Eugene Braunwald
21 Infections of the Skin, Muscle, and Soft Tissues		230	(7)
Dennis L. Stevens
22 Osteomyelitis		237	(7)
Jeffrey Parsonnet
23 Infectious Arthritis		244	(8)
Lawrence C. Madoff
24 Intraabdominal Infections and Abscesses		252	(8)
Miriam J. Baron
Dennis L. Kasper
25 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning		260	(8)
Joan R. Butterton
Stephen B. Calderwood
26 Acute Appendicitis and Peritonitis		268	(4)
Susan L. Gearhart
William Silen
27 Urinary Tract Infections, Pyelonephritis, and Prostatitis		272	(11)
Walter E. Stamm
28 Sexually Transmitted Infections: Overview and Clinical Approach		283	(20)
King K. Holmes
29 Meningitis, Encephalitis, Brain Abscess, and Empyema		303	(30)
Karen L. Roos
Kenneth L. Tyler
30 Chronic and Recurrent Meningitis		333	(8)
Walter J. Koroshetz
Morton N. Swartz
31 Chronic Fatigue Syndrome		341	(2)
Stephen E. Straus
32 Infectious Complications of Burns and Bites		343	(11)
Lawrence C. Madoff
Florencia Pereyra
SECTION IV BACTERIAL INFECTIONS
Part 1 Approach to Therapy for Bacterial Diseases
33 Treatment and Prophylaxis of Bacterial Infections		354	(20)
Gordon L. Archer
Ronald E. Polk
Part 2 Diseases Caused by Gram-Positive Bacteria
34 Pneumococcal Infections		374	(12)
Daniel M. Musher
35 Staphylococcal Infections		386	(13)
Franklin D. Lowy
36 Streptococcal and Enterococcal Infections		399	(13)
Michael R. Wessels
37 Acute Rheumatic Fever		412	(6)
Jonathan R. Carapetis
38 Diphtheria and Other Infections Caused by Corynebacteria and Related Species		418	(8)
William R. Bishai
John R. Murphy
39 Infections Caused by Listeria Monocytogenes		426	(3)
Elizabeth L. Hohmann
Daniel A. Portnoy
40 Tetanus		429	(5)
Elias Abrutyn
41 Botulism		434	(4)
Elias Abrutyn
42 Gas Gangrene and Other Clostridial Infections		438	(7)
Dennis L. Kasper
Lawrence C. Madoff
43 Clostridium Difficile---Associated Disease, Including Pseudomembranous Colitis		445	(5)
Dale N. Gerding
Stuart Johnson
Part 3 Diseases Caused by Gram-Negative Bacteria
44 Meningococcal Infections		450	(9)
Lee M. Wetzler
45 Gonococcal Infections		459	(10)
Sanjay Ram
Peter A. Rice
46 Moraxella Infections		469	(3)
Daniel M. Musher
47 Haemophilus Infections		472	(5)
Timothy F. Murphy
48 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria		477	(4)
Tamar F. Barlam
Dennis L. Kasper
49 Legionella Infection		481	(6)
Miguel Sabria
Victor L. Yu
50 Pertussis and Other Bordetella Infections		487	(6)
Scott A. Halperin
51 Diseases Caused by Gram-Negative Enteric Bacilli		493	(13)
Thomas A. Russo
James R. Johnson
52 Helicobacter Pylori Infections		506	(6)
John C. Atherton
Martin J. Blaser
53 Infections Due to Pseudomonas Species and Related Organisms		512	(9)
Reuben Ramphal
54 Salmonellosis		521	(9)
David A. Pegues
Samuel I. Miller
55 Shigellosis		530	(6)
Philippe Sansonetti
Jean Bergounioux
56 Infections Due to Campylobacter and Related Species		536	(4)
Martin J. Blaser
57 Cholera and Other Vibrioses		540	(7)
Matthew K. Waldor
Gerald T. Keusch
58 Brucellosis		547	(5)
Michael J. Corbel
Nicholas J. Beeching
59 Tularemia		552	(6)
Richard F. Jacobs
Gordon E. Schutze
60 Plague and Other Yersinia Infections		558	(11)
David T. Dennis
Grant L. Campbell
61 Bartonella Infections, Including Cat-Scratch Disease		569	(5)
David H. Spach
Emily Darby
62 Donovanosis		574	(2)
Gavin Hart
Part 4 Miscellaneous Bacterial Infections
63 Nocardiosis		576	(5)
Gregory A. Filice
64 Actinomycosis		581	(5)
Thomas A. Russo
65 Infections Due to Mixed Anaerobic Organisms		586	(10)
Dennis L. Kasper
Ronit Cohen-Poradosu
Part 5 Mycobacterial Diseases
66 Tuberculosis		596	(21)
Mario C. Raviglione
Richard J. O'Brien
67 Leprosy (Hansen's Disease)		617	(10)
Robert H. Gelber
68 Nontuberculous Mycobacteria		627	(8)
C. Fordham von Reyn
69 Antimycobacterial Agents		635	(9)
Richard J. Wallace, Jr.
David E. Griffith
Part 6 Spirochetal Diseases
70 Syphilis		644	(12)
Sheila A. Lukehart
71 Endemic Treponematoses		656	(4)
Sheila A. Lukehart
72 Leptospirosis		660	(5)
Peter Speelman
Rudy Hartskeerl
73 Relapsing Fever		665	(5)
David T. Dennis
74 Lyme Borreliosis		670	(6)
Allen C. Steere
Part 7 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
75 Rickettsial Diseases		676	(12)
David H. Walker
J. Stephen Dumler
Thomas Marrie
76 Infections Due to Mycoplasmas		688	(4)
William M. McCormack
77 Chalamydial Infections		692	(14)
Walter E. Stamm
SECTION V VIRAL INFECTIONS
Part 1 Viral Diseases: General Considerations
78 Medical Virology		706	(11)
Fred Wang
Elliott Kieff
79 Antiviral Chemotherapy, Excluding Antiretroviral Drugs		717	(13)
Lindsey R. Baden
Raphael Dolin
Part 2 Infections Due to DNA Viruses
80 Herpes Simplex Viruses		730	(10)
Lawrence Corey
81 Varicella-Zoster Virus Infections		740	(5)
Richard J. Whitley
82 Epstein-Barr Virus Infections, Including Infections Mononucleosis		745	(6)
Jeffrey I. Cohen
83 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8		751	(6)
Martin S. Hirsch
84 Molluscum Contagiosum, Monkeypox, and Other Poxviruses, Excluding Smallpox Virus		757	(2)
Fred Wang
85 Parvovirus Infections		759	(3)
Kevin E. Brown
86 Human Papillomavirus Infections		762	(4)
Richard C. Reichman
Part 3 Infections Due to DNA and RNA Respiratory Viruses
87 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)		766	(10)
Raphael Dolin
88 Influenza		776	(9)
Raphael Dolin
Part 4 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
89 The Human Retroviruses		785	(7)
Dan L. Longo
Anthony S. Fauci
90 Human Immunodeficiency Virus Disease: AIDS and Related Disorders		792	(95)
Anthony S. Fauci
H. Clifford Lane
Part 5 Infections Due to RNA Viruses
91 Viral Gastroenteritis		887	(6)
Umesh D. Parashar
Roger I. Glass
92 Acute Viral Hepatities		893	(24)
Jules L. Dienstag
93 Chronic Hepatitis		917	(22)
Jules L. Dienstag
94 Enteroviruses and Reoviruses		939	(8)
Jeffrey I. Cohen
95 Measles (Rubeola)		947	(5)
Anne Gershon
96 Rubella (German Measles)		952	(4)
Anne Gershon
97 Mumps		956	(3)
Anne Gershon
98 Rabies and Other Rhabdovirus Infections		959	(6)
Alan C. Jackson
Eri C. Johannsen
99 Infections Caused by Arthropod-and Rodent-Borne Viruses		965	(20)
Clarence J. Peters
100 Ebola and Marburg Viruses		985	(5)
Clarence J. Peters
SECTION VI PRION DISEASES
101 Prion Diseases		990	(10)
Stanley B. Prusiner
Bruce L. Miller
SECTION VII FUNGAL AND ALGAL INFECTIONS
102 Diagnosis and Treatment of Fungal Infections		1000	(3)
John E. Edwards, Jr.
103 Histoplasmosis		1003	(4)
Chadi A. Hage
L. Joseph Wheat
104 Coccidioidomycosis		1007	(4)
Neil M. Ampel
105 Blastomycosis		1011	(2)
Stanley W. Chapman
Donna C. Sullivan
106 Cryptococcosis		1013	(4)
Arturo Casadevall
107 Candidiasis		1017	(4)
John E. Edwards, Jr.
108 Aspergillosis		1021	(7)
David W. Denning
109 Mucormycosis		1028	(3)
Alan M. Sugar
110 Miscallaneous Mycoses and Algal Infections		1031	(6)
Stanley W. Chapman
Donna C. Sullivan
111 Pneumocystic Infection		1037	(5)
A. George Smulian
Peter D. Walzer
SECTION VIII PROTOZOAL AND HELMINTHIC INFECTIONS
Part 1 Parasitic Infections: General Considerations
112 Laboratory Diagnosis of Parasitic Infections		1042	(8)
Sharon L. Reed
Charles E. Davis
113 Agents Used to Treat Parasitic Infections		1050	(9)
Thomas A. Moore
114 Pharamacology of Agents Used to Treat Parasitic Infections		1059	(11)
Thomas A. Moore
Part 2 Protozoal Infections
115 Amebiasis and Infection With Free-Living Amebas		1070	(7)
Sharon L. Reed
116 Malaria		1077	(20)
Nicholas J. White
Joel G. Breman
117 Babesiosis		1097	(3)
Jeffrey A. Gelfand
Edouard Vannier
118 Atlas of Blood Smears of Malaria and Babesiosis		1100	(4)
Nicholas J. White
Joel G. Breman
119 Leishmaniasis		1104	(7)
Barbara L. Herwaldt
120 Trypanosomiasis		1111	(7)
Louis V. Kirchhoff
121 Toxoplasma Infections		1118	(9)
Lloyd H. Kasper
122 Protozoal Intestinal Infections and Trichomoniasis		1127	(6)
Peter F. Weller
Part 3 Helminthic Infections
123 Trichinella and Other Tissue Nematodes		1133	(6)
Peter F. Weller
124 Intestinal Nematodes		1139	(6)
Peter F. Weller
Thomas B. Nutman
125 Filarial and Related Infections		1145	(9)
Thomas B. Nutman
Peter F. Weller
126 Schistosomiasis and Other Trematode Infections		1154	(9)
Adel A.F. Mahamoud
127 Cestodes		1163	(10)
A. Clinton White, Jr.
Peter F. Weller
Appendix Laboratory Values of Clinical Importance		1173	(22)
Alexander Kratz
Michael A. Pesce
Daniel J. Fink
Review and Self-Assessment		1195	(36)
Charles Wiener
Gerald Bloomfield
Cynthia D. Brown
Joshua Schiffer
Adam Spivak
Index		1231

Dennis L. Kasper, MD William Ellery Channing Professor of Medicine Professor of Microbiology and Molecular Genetics Harvard Medical School Director, Channing Laboratory, Department of Medicine Brigham and Women's Hospital Boston, MA Anthony S. Fauci, MD Chief, Laboratory of Immunoregulation Director, National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD