If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding.
Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, 'personalized medicine', gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative medicines and nutraceuticals has been introduced and Further Reading lists have been updated to include key medical websites.
All medical students and junior doctors who read this book will learn not only how to use drugs safely and effectively, but, importantly, the rationale behind effective prescribing decisions.
Arvustused
"This is an excellent source for medical students and young doctors who are learning the art of using drugs in medical practice." Thomas L. Pazdernik (University of Kansas), Doody's Publishing Service
"If you only buy one clinical pharmacology textbook for medical school, make it this one." Oxford Medical School Gazette
Foreword |
|
viii |
|
Preface |
|
ix |
|
Acknowledgements |
|
x |
|
|
PART I GENERAL PRINCIPLES |
|
|
1 |
(102) |
|
Introduction to therapeutics |
|
|
3 |
(3) |
|
Mechanisms of drug action (pharmacodynamics) |
|
|
6 |
(5) |
|
|
11 |
(6) |
|
Drug absorption and routes of administration |
|
|
17 |
(7) |
|
|
24 |
(7) |
|
|
31 |
(3) |
|
Effects of disease on drug disposition |
|
|
34 |
(7) |
|
Therapeutic drug monitoring |
|
|
41 |
(4) |
|
|
45 |
(7) |
|
Drugs in infants and children |
|
|
52 |
(4) |
|
|
56 |
(6) |
|
|
62 |
(9) |
|
|
71 |
(8) |
|
|
79 |
(7) |
|
Introduction of new drugs and clinical trials |
|
|
86 |
(6) |
|
Cell-based and recombinant DNA therapies |
|
|
92 |
(5) |
|
Alternative medicines: herbals and nutraceuticals |
|
|
97 |
(6) |
|
PART II THE NERVOUS SYSTEM |
|
|
103 |
(62) |
|
Hypnotics and anxiolytics |
|
|
105 |
(5) |
|
Schizophrenia and behavioural emergencies |
|
|
110 |
(6) |
|
|
116 |
(8) |
|
Movement disorders and degenerative CNS disease |
|
|
124 |
(9) |
|
|
133 |
(9) |
|
|
142 |
(3) |
|
Anaesthetics and muscle relaxants |
|
|
145 |
(10) |
|
Analgesics and the control of pain |
|
|
155 |
(10) |
|
PART III THE MUSCULOSKELETAL SYSTEM |
|
|
165 |
(10) |
|
Anti-inflammatory drugs and the treatment of arthritis |
|
|
167 |
(8) |
|
PART IV THE CARDIOVASCULAR SYSTEM |
|
|
175 |
(56) |
|
Prevention of atheroma: lowering plasma cholesterol and other approaches |
|
|
177 |
(8) |
|
|
185 |
(11) |
|
|
196 |
(8) |
|
Anticoagulants and antiplatelet drugs |
|
|
204 |
(7) |
|
|
211 |
(6) |
|
|
217 |
(14) |
|
PART V THE RESPIRATORY SYSTEM |
|
|
231 |
(14) |
|
Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders |
|
|
233 |
(12) |
|
PART VI THE ALIMENTARY SYSTEM |
|
|
245 |
(26) |
|
Alimentary system and liver |
|
|
247 |
(18) |
|
Vitamins and trace elements |
|
|
265 |
(6) |
|
PART VII FLUIDS AND ELECTROLYTES |
|
|
271 |
(12) |
|
Nephrological and related aspects |
|
|
273 |
(10) |
|
PART VIII THE ENDOCRINE SYSTEM |
|
|
283 |
(38) |
|
|
285 |
(7) |
|
|
292 |
(5) |
|
|
297 |
(5) |
|
|
302 |
(5) |
|
Reproductive endocrinology |
|
|
307 |
(9) |
|
The pituitary hormones and related drugs |
|
|
316 |
(5) |
|
PART IX SELECTIVE TOXICITY |
|
|
321 |
(66) |
|
|
323 |
(11) |
|
|
334 |
(6) |
|
Fungal and non-HIV viral infections |
|
|
340 |
(11) |
|
|
351 |
(10) |
|
Malaria and other parasitic infections |
|
|
361 |
(6) |
|
|
367 |
(20) |
|
|
387 |
(10) |
|
Anaemia and other haematological disorders |
|
|
389 |
(8) |
|
PART XI IMMUNOPHARMACOLOGY |
|
|
397 |
(12) |
|
Clinical immunopharmacology |
|
|
399 |
(10) |
|
|
409 |
(12) |
|
|
411 |
(10) |
|
|
421 |
(10) |
|
|
423 |
(8) |
|
PART XIV CLINICAL TOXICOLOGY |
|
|
431 |
(20) |
|
|
433 |
(11) |
|
Drug overdose and poisoning |
|
|
444 |
(7) |
Index |
|
451 |
|
James Ritter, Professor of Clinical Pharmacology at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UK
Lionel Lewis, Professor of Medicine, Pharmacology and Toxicology at Dartmouth Medical School, Lebanon, New Hampshire, USA
Tim Mant, Senior Medical Advisor at Quintiles, Guy's Drug Research Unit, and Visiting Professor at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UK
Albert Ferro, Reader in Clinical Pharmacology at King's College London School of Medicine, Guy's, King's and St Thomas' Hospitals, London, UK