Principles and Practice of Clinical Virology 6th Revised edition [Kõva köide]

  • Formaat: Hardback, 1042 pages, kõrgus x laius x paksus: 249x195x61 mm, kaal: 2094 g, Illustrations
  • Ilmumisaeg: 28-May-2009
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 0470517999
  • ISBN-13: 9780470517994
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  • Formaat: Hardback, 1042 pages, kõrgus x laius x paksus: 249x195x61 mm, kaal: 2094 g, Illustrations
  • Ilmumisaeg: 28-May-2009
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 0470517999
  • ISBN-13: 9780470517994
Teised raamatud teemal:
This sixth edition is a comprehensive, updated guide to clinical virology. Zuckerman (UCL medical school, London) and the editors and contributors give detailed studies of the many viral infections that humans are subject to. Chapters range from the common cold to childhood diseases like mumps and measles to herpes viruses, rabies, HIV and pox. Each article gives the taxonomy, morphology, and epidemiology of the virus along with issues specific to each. Diagnosis and treatment are discussed, of course, along with diagrams and slides of the virus. A bibliography of the major articles on the virus is given. The introductory chapters are on general topics such as diagnostic approaches, modes of infection, emerging new viruses, and an overview of vaccinations along with advice on combating myths that prevent people from coming in to get them. Health professionals will find this an invaluable reference. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)

Principles and Practice of Clinical Virology is the bible for all working in the field of clinical virology – from the trainee to the expert because there’s always something new to learn! As before, the book provides a detailed account of the diagnosis and treatment of virus infections, with a stronger emphasis on clinical expertise and management. Each chapter deals with a single virus or group or viruses and is written by leading international experts in the field.

What’s new in this edition …

  • Showcases the wealth of new knowledge acquired on virus infections and reflects the discovery of newly recognized emerging infections, the improvement or development of new vaccines, and an increasing repertoire of antiviral agents for treatment
  • All chapters have been thoroughly revised and there are a number of new contributors, joining the cadre of internationally-recognized experts
  • Includes a new chapter on vaccinology covering the principles relating to the development and use of vaccines generally, which complements the specific vaccines described in the other chapters
  • The two chapters on nosocomial infections have been enlarged and will be particularly useful for those having to advise on the management of hospital-acquired infections
  • Emphasizes the rapid accumulation of new information in such fields as retroviruses, particularly HIV, SARS, hepatitis C and influenza, including avian influenza

Arvustused

"There is a wealth of useful information in this book. ... I predict that there will be fierce competition to consult it!" (Microbiology Today, November 2009) "Chapters are very well written in styles that are easy to follow. ... A most valuable book for infectious disease clinicians, students and biomedical scientists." (Royal Society of Tropical Medicine and Hygiene, October 2009) "This sixth edition is a comprehensive, updated guide to clinical virology." (Book News, September 2009)

List of Contributors
xi
Preface xiii
Past, Present and Future of Clinical Virology: An Overview xv
Diagnostic Approaches
1(28)
Katie Jeffery
Emma Aarons
Introduction
1(1)
Electron Microscopy
2(1)
Histology/Cytology
2(1)
Virus Isolation
2(1)
Serology
3(5)
Molecular Amplification Techniques
8(12)
Recommended Diagnostic Investigations
20(2)
Future Trends
22(7)
Viral Transmission: Infection Acquired by the Blood-borne Route
29(14)
Will Irving
Introduction
29(1)
Prevention of Exposure through Infection Control
30(1)
Prevention of Infection through Specific Pre- and Post-exposure Policies
30(1)
Patient-to-patient Transmission
30(2)
Patient-to-HCW Transmission
32(4)
HCW-to-patient Transmission
36(7)
Viral Transmission: Infection Acquired by All Other Routes (Respiratory, Eye-Nose-Mouth, Inoculation and Faeco-orally)
43(26)
Philip Rice
Introduction
43(1)
Measles, Mumps and Rubella
44(3)
Cytomegalovirus
47(1)
Varicella Zoster Virus
48(5)
Herps Simplex Virus
53(1)
Noroviruses
54(2)
Rotavirus
56(1)
Parvovirus B19
56(2)
Respiratory Viruses
58(11)
Emerging Virus Infections
69(12)
Brain W. J. Mahy
Introduction
69(1)
Factors Contributing to Emergence
69(8)
Future Directions
77(4)
Vaccinology
81(14)
Francis E. Andre
Hugues H. Bogaerts
Introduction
81(1)
Burden of Viral Diseases and their Reproductive Rates
82(1)
The Immune System and its Role in Natural and Artificially-induced Immunity
83(2)
Discovery of Protective Antigens in Pathogens
85(1)
Presentation of Protective Antigens through Vaccines and Types of Vaccine
86(1)
Research and Development on Vaccines and their Commercial Introduction
86(2)
Social Marketing of Introduced Vaccines
88(1)
Planning and Implementation of Vaccination Programmes
89(1)
Surveillance of Disease Incidence and Adverse Events Before and After Implementation of Vaccination
89(1)
Rectification of Publicized Falsehoods and Maintenance of Vaccination Coverage
89(1)
Viral Vaccines on the Horizon and the Roadblocks to Future Vaccine Development
90(1)
Closing comments
91(4)
Herpes Simplex Virus Type 1 and Type 2
95(38)
Marianne Forsgren
Paul E. Klapper
Morphology
95(2)
Replication
97(6)
Epidemiology
103(2)
Viral Diagnosis
105(3)
Antiviral Chemotherapy
108(4)
Clinical Features, Diagnosis and Management
112(16)
Concluding Remarks
128(5)
Varicella Zoster
133(28)
Judith Breuer
Introduction
133(1)
The Virus
133(9)
Epidemiology
142(1)
Clinical Features
143(5)
Diagnosis of VZV Infection
148(3)
Treatment
151(2)
Prevention
153(8)
Cytomegalovirus
161(38)
Paul D. Griffiths
Introduction
161(1)
The Virus
161(5)
Epidemiology
166(1)
Routes of Infection
167(1)
Pathogenesis
168(5)
Clinical Features
173(2)
Diagnosis
175(5)
Management
180(3)
Prevention
183(2)
Treatment
185(14)
Epstein-Barr Virus
199(24)
Tanzina Haque
Dorothy H. Crawford
Introduction
199(1)
The Virus
199(5)
Epidemiology
204(1)
EBV-associated Diseases
205(10)
EBV Infection in the Immunocompromized Host
215(3)
Vaccine Development
218(5)
Roseoloviruses: Human Herpesviruses 6A, 6B and 7
223(22)
Katherine N. Ward
Duncan A. Clark
Introduction
223(1)
Biology of the Viruses
223(5)
Epidemiology and Pathogenesis
228(3)
Disease Associations
231(5)
Laboratory Diagnosis
236(4)
Antiviral Therapy
240(1)
Concluding Remarks
240(5)
Kaposi's Sarcoma-associated Herpesvirus (Human Herpesvirus 8)
245(28)
Cornelia Henke-Gendo
Abel Viejo-Borbolla
Thomas F. Schulz
Introduction
245(1)
Origin and Evolution of KSHV
245(2)
Worldwide Distribution of KSHV in the General Population
247(2)
Transmission
249(2)
Clinical Manifestations
251(3)
Pathogenesis
254(7)
Diagnostic Assays
261(2)
Antiviral Therapy
263(10)
Hepatitis Viruses
273(48)
Tim J. Harrison
Geoffrey M. Dusheiko
Arie J. Zuckerman
Introduction
273(2)
Hepatitis A
275(5)
Hepatitis E
280(2)
Hepatitis B
282(25)
Hepatitis D
307(2)
Hepatitis C
309(12)
GB Virus C (GBV-C) and Torque Teno Virus (TTV)
321(16)
Shigeo Hino
Introduction
321(1)
GB Virus C (GBV-C)
321(4)
Torque Teno Virus (TTV)
325(12)
Rotaviruses
337(18)
Ulrich Desslberger
Jim Gray
Introduction
337(1)
Rotavirus Structure, Genome and Gene-Protein Assignment
337(1)
Classification
337(1)
Replication
338(4)
Pathogenesis
342(1)
Immune Responses and Correlates of Protection
343(1)
Illness, Diagnosis and Treatment
343(1)
Epidemiology
344(1)
Vaccine Development
345(10)
Viruses other than Rotaviruses Associated with Acute Diarrhoeal Disease
355(18)
Jim Gray
Ulrich Desselberger
Introduction
355(2)
Enteric Adenoviruses
357(1)
Noroviruses and Sapoviruses (Human Caliciviruses)
358(5)
Astroviruses
363(1)
Gastrointestinal Viruses Not Regularly Associated with Acute Diarrhoeal Disease
364(9)
Influenza
373(36)
Maria Zambon
Chris W. Potter
Introduction
373(7)
Viral Variation
380(4)
Virus Classification
384(1)
Pathogenesis
385(3)
Clinical Features
388(3)
Diagnosis of Infection
391(5)
Treatment and Prevention
396(13)
Parainfluenza Viruses
409(32)
Stelios Psarras
Nikolaos G. Papadopoulos
Sebastian L. Johnston
Introduction
409(1)
Taxonomy
409(1)
Structure and Physical Properties
410(1)
Receptors, Virus Entry and Host Range
411(3)
Replication
414(2)
Viral Transmission, Incubation and Shedding
416(1)
Pathogenesis
417(1)
Antigenicity and Immunity
418(2)
Epidemiology
420(3)
Clinical Features
423(2)
Diagnosis
425(3)
Prevention
428(1)
Treatment
429(12)
Respiratory Syncytial Virus
441(22)
Caroline Breese Hall
Introduction
441(1)
The Virus
441(1)
Epidemiology
442(2)
Pathogenesis
444(1)
Immunity
445(1)
Clinical Features
446(4)
Diagnosis
450(2)
Management
452(1)
Prevention
453(10)
Adenoviruses
463(26)
Marcela Echavarria
Introduction
463(1)
Description and Characteristics of the Virus
464(4)
Pathogenesis
468(1)
Immune Response
469(1)
Epidemiology
470(1)
Clinical Features
471(1)
Respiratory Infections
471(3)
Ocular Infections
474(1)
Gastrointestinal Infections
475(1)
Haemorrhagic Cystitis
475(1)
Adenoviruses Infections in Immunocompromized Patients
475(2)
Other Clinical Manifestations
477(1)
Diagnosis
477(4)
Treatment
481(1)
Prevention
482(1)
Future Prospects
483(6)
Rhinoviruses
489(22)
Nikolaos G. Papadopoulos
Maria Xatzipsalti
Sebastian L. Johnston
Introduction
489(1)
Taxonomy
489(3)
Physical Properties
492(1)
Incubation and Transmission
492(1)
Host Range
493(1)
Pathogenesis
493(2)
Immunity
495(1)
Epidemiology
496(1)
Clinical Features
497(1)
Diagnosis
498(2)
Prevention and Treatment
500(11)
Coronaviruses and Toroviruses
511(22)
J. S. Malik Peiris
L. L. M. Poon
Introduction
511(1)
The Viruses
511(6)
Initiation of Infection and Pathogenesis
517(2)
Epidemiology
519(1)
Clinical Features
520(3)
Diagnosis
523(1)
RT-PCR
524(1)
Prophylaxis: Active and Passive Immunization
525(1)
Therapy
526(1)
Acknowledgements
526(7)
Measles Virus
533(28)
Sibylle Schneider-Schaulies
Volker ter Meulen
Introduction
533(1)
The Virus
533(2)
Virus Morphology
535(1)
Genome Structure
535(1)
MV Protein Functions
536(2)
The Replication Cycle
538(2)
Biological Properties of the Measles Virus
540(1)
Epidemiology and Relatedness of Different Virus Isolates
541(1)
Clinical Manifestations
542(3)
The Pathogenesis of Measles and its Complications
545(6)
Diagnosis
551(1)
Management
552(1)
Prevention
552(9)
Rubella
561(32)
Jennifer M. Best
Joseph P. Icenogle
David W. G. Brown
Historical Introduction
561(1)
The Virus
562(3)
Postnatally Acquired Infection
565(4)
Congenitally Acquired Infection
569(7)
Laboratory Techniques and Diagnosis
576(4)
Prevention---Rubella Vaccination
580(13)
Mumps
593(8)
Pauli Leinikki
Introduction
593(1)
The Virus
593(2)
Pathogenesis
595(1)
Clinical Picture
595(2)
Laboratory Diagnosis
597(1)
Epidemiology and Control
598(3)
Enteroviruses
601(24)
Philip D. Minor
Peter Muir
Introduction
601(1)
The Viruses
601(7)
Pathobiological and Clinical Aspects of Human Enteroviruses
608(7)
Laboratory Diagnosis of Enterovirus Infections
615(2)
Prevention and Treatment of Enterovirus Infection
617(3)
Future Prospects
620(5)
Poxviruses
625(18)
Peter B. Jahrling
Introduction
625(1)
Virus Characteristics
625(2)
Clinical Aspects of Orthopoxvirus Infections
627(5)
Diagnosis
632(2)
Medical Management
634(1)
Other Poxviruses Infecting Humans
635(2)
Diagnosis
637(6)
Alphaviruses
643(26)
Graham Lloyd
Introduction
643(1)
The Virus
643(4)
Spectrum of Diseases Caused by Alphaviruses
647(1)
Diagnosis of Alphavirus Infections
647(1)
Management and Prevention
647(1)
Alphaviruses Associated with Fevers and Polyarthritis
648(8)
Alphaviruses Associated with Encephalitis
656(5)
Other Alphaviruses
661(8)
Flaviviruses
669(30)
Barry D. Schoub
Marietjie Venter
Introduction
669(1)
Properties of the Virus
670(2)
Yellow Fever
672(6)
Other Members of the `Unassigned' Subgroup of Flaviviruses
678(1)
Dengue
678(6)
Zika
684(1)
Japanese Encephalitis
684(3)
St Louis Encephalitis
687(1)
West Nile Virus
688(2)
Murray Valley Encephalitis
690(1)
Tick-borne Encephalitis
691(3)
Omsk Haemorrhagic Fever
694(1)
Kyasanur Forest Disease
694(1)
Powassan Virus
695(4)
Bunyaviridae
699(34)
Robert Swanepoel
Felicity J. Burt
Introduction
699(1)
The Virus
700(3)
Laboratory Diagnosis
703(3)
Genus Orthobunyavirus
706(5)
Genus Phlebovirus
711(6)
Genus Nairovirus
717(4)
Genus Hantavirus
721(5)
Bunyaviruses Unassigned to Genus
726(7)
Arenaviruses
733(22)
Colin R. Howard
Introduction
733(2)
Ultrastructure of Arenaviruses and Infected Cells
735(2)
Chemical Composition
737(2)
Replication
739(1)
Diagnosis of Human Arenavirus Infections
740(1)
Antigenic Relationships
741(1)
Clinical and Pathological Aspects
741(2)
Persistent Infection
743(1)
Pathology of Arenavirus Infections: General Features
744(6)
Other Arenavirus Infections
750(1)
Summary
751(4)
Filoviruses
755(22)
Susan P. Fisher-Hoch
Introduction
755(1)
Epidemiology
756(5)
Ecology
761(2)
Transmission and Risk Factors
763(1)
Clinical Spectrum
763(1)
Laboratory Diagnosis
764(1)
Patient Management
765(1)
Past Infection and Persistence
766(1)
Virology
766(1)
Animal Models
767(1)
Serological Studies
768(1)
Pathogenesis and Immunology
768(1)
Control
769(1)
Perspective
770(7)
Rabies and Other Lyssavirus Infections
777(30)
Mary J. Warrell
Introduction
777(1)
History
777(1)
Classification
778(1)
Virus Structure
778(2)
Replication
780(1)
Inactivation of Virus and Stability of Vaccine Antigen
781(1)
Epizootiology and Epidemiology
781(2)
Incidence of Human Rabies
783(1)
Pathogenesis
783(2)
Immunology
785(1)
Routes of Infection
786(1)
Clinical Features of Rabies in Animals
787(1)
Clinical Features in Humans
787(7)
Diagnosis
794(2)
Management of Human Rabies
796(1)
Pathology
796(1)
Human Rabies Prophylaxis
797(3)
Control of Animal Rabies
800(7)
Papillomaviruses
807(16)
Dennis McCance
Introduction
807(1)
Classification
807(1)
Physical and Chemical Properties
807(4)
Serology
811(1)
Viral Replication
811(1)
Natural History of HPV Infections
812(1)
Pathogenesis
813(4)
Diagnosis
817(1)
Treatment
818(1)
Vaccination
819(4)
The Human Polyomaviruses
823(30)
Kristina Dorries
Classification and Detection
823(1)
Virion Structure and Composition
823(1)
Virus Life Cycle
823(10)
State of Human Polyomavirus Infection
833(10)
Diagnostic Evaluation of Polyomavirus-associated Disease
843(2)
Polyomavirus-specific Immune Response
845(2)
Treatment of Polyomavirus-associated Diseases
847(1)
Acknowledgements
848(5)
Human Parvoviruses
853(16)
Kevin E. Brown
Introduction
853(1)
Human Parvovirus B19 (B19V)
854(2)
Pathogenesis
856(2)
Epidemiology
858(1)
Clinical Features
859(4)
Laboratory Diagnosis
863(2)
Treatment and Prevention
865(4)
Human Retroviruses
869(6)
Robin A. Weiss
Introduction
869(1)
Retrovirus Replication and Genomes
869(1)
Taxonomy
870(1)
Human and Zoonotic Retrovirus Infections
870(2)
Retroviral Vectors
872(3)
The Human T-lymphotropic Viruses
875(22)
Graham P. Taylor
Introduction
875(1)
History
875(1)
The Virus
876(3)
Diagnosis
879(1)
Viral Variation
880(1)
Epidemiology
881(2)
Transmission
883(1)
HTLV-associated Disease
884(2)
Pathogenesis
886(3)
Treatment
889(2)
Prevention of Disease
891(1)
HIV and HTLV Co-infection
891(6)
Human Immunodeficiency Viruses
897(42)
Deenan Pillay
Anna Maria Geretti
Robin A. Weiss
Introduction and Classification
897(2)
Epidemiology
899(1)
Replication
900(3)
Host Genetic Determinants for HIV/AIDS
903(1)
Viral Dynamics and Pathogenesis
903(2)
Immune Responses
905(1)
The Laboratory Diagnosis of HIV Infection
906(3)
The Natural History of HIV Infection and Its Clinical Manifestations
909(7)
Antiretroviral Therapy---A Historical Perspective
916(1)
Monitoring of Antiretroviral Therapy and Resistance
917(4)
Antiretroviral Drug Classes
921(8)
Transmission of Drug Resistance
929(1)
Prevention
929(3)
Vaccines
932(7)
Human Prion Diseases
939(30)
John Collinge
Introduction to Prions and Historical Perspective
939(1)
Structural Biology of Prions
940(3)
Normal Cellular Function of PrP
943(1)
Prion Strain
943(2)
Neuronal Cell Death in Prion Disease
945(1)
The `Species Barrier'
945(1)
Pathogenesis
946(1)
Animal Prion Disease
947(1)
Aetiology and Epidemiology of Human Prion Disease
948(1)
Clinical Features and Diagnosis
949(10)
Molecular Diagnosis of Prion Disease
959(1)
Pre-symptomatic and Antenatal Testing
960(1)
Prevention and Public Health Management
960(1)
Prognosis and Treatment
961(1)
Concluding Remarks
962(1)
Useful Websites
962(7)
Index 969