The articles in this volume were solicited from conference participants who presented invited talks or posters. The meeting placed particular emphasis on experimental searches for deviations from CPT and Lorentz invariance and on the theoretical questions and frameworks that accompany such tests. On the experimental side, sessions featured astrophysical investigations involving neutrinos, photons, and gravitational waves; accelerator and storage-ring studies of neutral mesons, muons, quarks, and flavor-changing processes; laboratory tests of gravity; high-precision spectroscopy of ions, atoms, molecules, and exotic atoms; measurements of spin dynamics; comparisons of matter and antimatter; laser- and maser-based tests; neutron experiments; and studies using cavities, oscillators, resonators, as well as neutrino oscillations and propagation. Theoretical and phenomenological contributions addressed expected signals of CPT and Lorentz violation across particle physics, electromagnetism, and gravity; mechanisms and illustrative models for spacetime-symmetry breaking; developments in field theory, gravitation, and particle physics; and connections to condensed-matter systems.