This book provides a radiotherapy perspective on the management of brain metastases with case-based discussion. This management has been rapidly evolving in the face of changing technology, progressing systemic therapy, and paradigm changes that all impact practice. These changes can be difficult, and this text gives a practical approach to help practitioners and trainees understand these changes and incorporate them into their practices.
The work has two main sections: Clinical and Technical. The clinical section has chapters that address all aspects of radiation therapy for brain metastases, including integrating advances in surgery and drug treatments. The technical section focuses on the “how to” aspects of treatment, including treatment planning and delivery.
This is an ideal guide for practicing radiation oncologists and trainees.
Introduction.- SECTION I: Clinical Overview.- Brain Metastases
Introduction.- Radiobiology of Radiation Therapy for the Brain.- Supportive
Medical Management of Brain Metastases Patients.- Neuorimaging of Brain
Metastases.- Integrative Surgery and Radiosurgery.- Integrating Systemic
Therapy into Management.- Indications for SRS-Multiple Mets.- Rationale for
Hypofractionation.- Target Delineation for Radiosurgery.- Indications for
WBRT.- Particle Therapy for the Treatment of Brain Metastases.- Special
Topics.- Salvage, Reirradiation, and Retreatment.- SECTION II: Technical
Treatment Planning and Delivery.- General Techniques for Radiosurgery.-
Single Isocenter Techniques for Multiple Targets.- Dose Tolerances for Normal
Structures.- Metrics for Radiosurgery Plan.- Image Guidance for Frameless
Radiosurgery.- Safety Procedures and Checklists for Radiosurgery.- Quality
Assurance for Small Fields.- Techniques of WBRT.
Yoshiya Yamada MD FRCPC is Attending Radiation Oncologist in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center. Eric Chang MD, FASTRO is Professor and Chair in the Department of Radiation Oncology at Keck School of Medicine, University of Southern California. Dr. Chang is also volume editor of the forthcoming Adult CNS Radiation Oncology. John Fiveash MD is Professor and Vice Chair of the Department of Radiation Oncology at the University of Alabama Birmingham. Jonathan Knisely MD is in the Department of Radiation Oncology at Weill Cornell Medical Center.
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