Autophagy trilogy, Part C dives into the mature landscape of cellular housekeeping, weaving together the mechanistic precision of modern biology with the larger questions of health, aging, and resilience. Building on the foundations laid in Parts A and B, this book takes the reader from the microscopic machinery inside a single cell to the sweeping implications for organisms, ecosystems, and medicine.
1. Lysosomal Function and Homeostasis: From Cellular Adaptation to
Disease Pathogenesis
Maho Hamasaki
2. Autophagy Meets Plant Virology: From Molecular Crosstalk to Outstanding
Challenges
Carmen Hernández and Miryam Pérez-Cañamás
3. Impact of mitophagy on obesity-affected tissues
Pablo Miguel Garcia-Roves, Sandra Cutanda-Tesouro, Meritxell Espino-Guarch
and Rana El Nahhas
4. Autophagy in Endothelial Cells: a gatekeeper of immune cell trafficking
and function
Natalia Reglero Real, Guillermo Marcos-Zapatero, Dafne García-Mateos and
Irene Carriles-Moar
5. Viral Trafficking: The Role of Autophagy in the Release of Virus-Loaded
Extracellular Vesicles
Maria Chiara Maiuri, Jonathan Pol, Fatima Domenica Elisa De Palma, Mojgan
Djavaheri-Mergny, Lucio Pastore, Filippo Scialo, Laura Vipraio Tiberi and
Angelica Di Matteo
6. Sex matters in macroautophagy: sex-driven differences in autophagic
function in aging and aging related-diseases
Eloy Bejarano Fernández, Álvaro Fernández Fernández, José Ignacio
García-Muñoz, Alicia Domenech Bendaña, Lucia Gimeno-Mallench, Alejandro
Ponce-Mora, Daniel López-López and Jose Luis Nieto-Torres
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Jose Manuel Bravo-San Pedro is currently a researcher at the Department of Physiology of the Complutense University of Madrid thanks to a Ramon y Cajal contract grant. He got his Ph.D. in biochemistry, cellular biology and genetics from the University of Extremadura (Caceres, Spain) in 2011, and he did a post-doctoral stage in the laboratory of Prof. Guido Kroemer. His main research interests have always been linked to autophagy, addressing this cellular process associated with neurodegenerative diseases or cancer and recently obesity and specifically related to problems in the correct functioning of the cilium. He is co-inventor of two patents and co-author of 110 publications indexed in PubMed in prestigious international journals, with h-index 45 and 23768 cites (Dec 2022).
