| Contributors |
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ix | |
| Preface |
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xi | |
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1 | (58) |
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2 | (1) |
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2 The developmental genetics of Hh signaling in Drosophila |
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2 | (11) |
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3 The developmental genetics of Hh signaling in vertebrates |
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13 | (6) |
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4 Multiple protein interactions mediate reception of the Hh signal |
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19 | (3) |
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5 Structure and biosynthesis of Hh proteins |
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22 | (1) |
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6 Release and movement of Hh proteins from producing cells |
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23 | (7) |
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7 Reception of HH at the membrane: the role of Patched and Smoothened |
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30 | (5) |
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8 The intracellular response to Hh |
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35 | (8) |
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43 | (16) |
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44 | (1) |
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44 | (15) |
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2 Different strategies by distinct Wnt-signaling pathways in activating a nuclear transcriptional response |
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59 | (32) |
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1 Overview of Wnt-signaling pathways |
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60 | (10) |
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2 Induction of nuclear responses downstream of Wnt-signaling |
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70 | (7) |
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3 How does (3-catenin get transported into the nucleus |
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77 | (4) |
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81 | (10) |
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82 | (1) |
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83 | (8) |
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3 Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis |
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91 | (32) |
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92 | (1) |
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2 Components of the Hippo pathway and their regulation |
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93 | (6) |
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3 The contribution of resident CFs to cardiac fibrosis |
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99 | (7) |
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4 Outstanding questions and future directions |
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106 | (4) |
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110 | (13) |
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111 | (1) |
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111 | (12) |
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4 Pulling back the curtain: The hidden functions of receptor tyrosine kinases in development |
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123 | (30) |
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124 | (1) |
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2 Receptor tyrosine kinase signaling |
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125 | (2) |
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3 Dismantling RTK signaling one pathway at a time |
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127 | (9) |
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4 Without canonical signaling, what novel functions are revealed? |
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136 | (8) |
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144 | (9) |
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146 | (1) |
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146 | (7) |
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5 Cellular and molecular mechanisms of EPH/EPHRIN signaling in evolution and development |
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153 | (50) |
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154 | (8) |
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2 EPH/EPHRIN function through an evolutionary lens |
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162 | (10) |
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3 Cellular mechanisms underlying EPH/EPHRIN-mediated cell sorting and boundary formation |
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172 | (9) |
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4 Nervous system development |
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181 | (3) |
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5 Craniofacial and musculoskeletal development |
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184 | (3) |
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6 Conclusions and perspectives |
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187 | (16) |
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188 | (1) |
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188 | (15) |
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6 Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood |
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203 | (60) |
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204 | (3) |
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2 A common origin of vascular and hematopoietic cells |
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207 | (2) |
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3 Involvement of integrins in the establishment of the hematopoietic system |
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209 | (17) |
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4 Contribution of integrin-mediated adhesion to life-long hematopoiesis |
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226 | (8) |
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5 Integrin-mediated mechanosensing in the HSPC niche |
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234 | (2) |
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6 Integrin-mediated support of leukemic stem cells |
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236 | (1) |
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237 | (26) |
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239 | (1) |
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239 | (24) |
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7 Putting in the Erk: Growth factor signaling and mesoderm morphogenesis |
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263 | (48) |
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264 | (2) |
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2 The fates of vertebrate mesodermal populations marked by brachyury |
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266 | (3) |
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3 FGF expression in the mesoderm: An upstream cue for ERK-dependent gene induction |
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269 | (5) |
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4 Generation and interpretation of transient ERK signaling in vertebrate mesoderm |
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274 | (5) |
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5 The role of ERK signaling in initiating and sustaining brachyury expression |
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279 | (3) |
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6 A role for ERK and a brachyury homology in Drosophila mesoderm specification |
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282 | (4) |
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7 Moving mesoderm: ERK-dependent control of convergence and extension |
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286 | (3) |
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8 Erk regulation of epithelial-to-mesenchymal transition in the primitive streak |
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289 | (2) |
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9 A potential role for ERK signaling in mesodermal directed cell migration |
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291 | (3) |
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10 Open questions and new tools for ERK control over mesoderm specification and movement |
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294 | (17) |
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300 | (1) |
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300 | (11) |
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8 Establishment and interpretation of NODAL and BMP signaling gradients in early vertebrate development |
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311 | (30) |
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312 | (3) |
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315 | (9) |
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324 | (8) |
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4 Interactions between NODAL and BMP signaling |
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332 | (2) |
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334 | (7) |
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334 | (1) |
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334 | (7) |
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9 Signaling oscillations in embryonic development |
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341 | (32) |
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342 | (5) |
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2 Single-cell oscillation dynamics |
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347 | (8) |
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3 Tissue-wide oscillation dynamics |
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355 | (7) |
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362 | (11) |
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365 | (1) |
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365 | (8) |
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10 Parallels in signaling between development and regeneration in ectodermal organs |
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373 | |
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374 | (5) |
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2 From signaling centers during development to stem cell regulated morphogenesis in the adult |
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379 | (7) |
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386 | (6) |
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392 | (5) |
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397 | (4) |
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401 | (5) |
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7 Conclusion--The regenerative properties of the ectoderm |
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406 | |
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409 | (1) |
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409 | |
