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Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery [Pehme köide]

Edited by , Edited by (School of Nano Science and Technology (SNST), Indian Institute of Technology, Kharagpur), Edited by (LV Prasad Eye Inst), Edited by , Edited by (Distinguished USF Health Professor, Director of the Division of Translational Medicine, University of South Florida, USA)
  • Formaat: Paperback / softback, 682 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128140313
  • ISBN-13: 9780128140314
Teised raamatud teemal:
  • Formaat: Paperback / softback, 682 pages, kõrgus x laius: 235x191 mm, kaal: 450 g
  • Sari: Micro & Nano Technologies
  • Ilmumisaeg: 10-Oct-2018
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128140313
  • ISBN-13: 9780128140314
Teised raamatud teemal:

Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery describes the techniques successfully employed for the application of nanocarriers loaded with the antioxidant enzyme, catalase, and thus targeted to endothelial cells. Methods of nanocarrier synthesis, loading within various systems, and the characterization of nanocarriers for targeting activities are covered, as are their advantages, disadvantages and applications. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields, all with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields.

  • Enables readers from different fields to access recent research and protocols across traditional boundaries
  • Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques
  • Explores both current and emerging classes of nanomaterials, along with their fundamentals and applications
List of contributors
xix
Foreword xxiii
Chapter 1 Nanobiosensors for Biomedical Application: Present and Future Prospects
1(24)
Raghvendra Kumar Mishra
R. Rajakumari
1 Introduction
1(1)
2 Application of Nanotechnology in Biosensors
2(3)
3 Nanobiosensors in Biomedical Applications
5(9)
3.1 Nanobiosensor for Detection of Glucose
5(1)
3.2 Nanobiosensor for Detection of Cholesterol
6(1)
3.3 Nanobiosensor for Detection of Cancer/Tumor Biomarkers
7(1)
3.4 Nanobiosensor for Detection of Allergic Responses
8(2)
3.5 Nanobiosensor for Detection of Pathogenic Viruses (HIV Virus and Dengue Virus)
10(1)
3.6 Nanobiosensor for Detection of Pathogenic Bacteria
11(1)
3.7 Bioimaging
12(2)
4 Conclusions and Future Prospects
14(11)
References
14(11)
Chapter 2 Peptide-Based Drug Delivery Systems
25(22)
Ruchika Goyal
Vibin Ramakrishnan
1 Peptides in Targeted Drug Delivery
27(1)
2 Strategies for Peptide-Based Drag Design
28(3)
2.1 Torsion Angle and Peptide Backbone Alterations
29(1)
2.2 Peptidomimetics With Unnatural Amino Acids
30(1)
2.3 Macrocyclization of Peptides
30(1)
3 Peptides as Carriers for Drug Delivery
31(9)
3.1 Targeting Peptides
31(7)
3.2 Cell-Penetrating Peptides
38(2)
4 Future of Peptide-Based Drug Delivery Systems
40(7)
References
40(7)
Chapter 3 Lipid-Based Nanoparticles for Drug Delivery Systems
47(30)
Shabnam Samimi
Niloufar Maghsoudnia
Reza Baradaran Eftekhari
Farid Dorkoosh
1 Introduction
47(1)
2 Solid Lipid Nanoparticles
47(1)
3 Nanostructured Lipid Carriers
48(2)
4 Types of Nanostructured Lipid Carriers
50(1)
5 Fabrication Methods of Solid Lipid Nanoparticles
50(2)
5.1 High-Pressure Homogenization
51(1)
6 Microemulsion Technique
52(1)
7 Sterilization
52(1)
8 Characterization of Solid Lipid Nanoparticles
53(3)
8.1 Particle Shape and Size
53(1)
8.2 Zeta Potential
54(1)
8.3 Stability
54(2)
9 Lyophilization
56(1)
10 Application of Lipid Nanoparticles in Gene Delivery
56(1)
11 Application of SLNs and NLCs in Cancer Therapy: A New Hope for a Cancer-Free World
57(2)
12 Application of Lipid Nanoparticles in Protein and Peptide Delivery
59(1)
13 Application of Lipid Nanoparticles in Oral Drug Delivery
60(2)
14 Application of Lipid Nanoparticles in Brain Drug Delivery
62(1)
15 Application of Lipid Nanoparticles in Pulmonary Drug Delivery
63(1)
16 Application of Lipid Nanoparticles in Topical Drug Delivery
64(1)
17 Application of Lipid Nanoparticles in Ocular Drug Delivery
65(1)
18 Conclusion
66(11)
References
66(11)
Chapter 4 Graphene-Based Nanovehicles for Drug Delivery
77(36)
Harekrishna Roy
Satyabrata Bhanja
Uttam Prasad Panigrahy
Vinay Kumar Theendra
1 Introduction
77(1)
2 Properties
78(1)
3 Behavior of Graphene
78(4)
3.1 Graphene and Biologic Fluids
78(2)
3.2 Inflammatory and Immune Response to Graphene
80(1)
3.3 Interaction of Graphene and Blood Components
80(1)
3.4 Bioaccumulation of Graphene
81(1)
3.5 Cellular Uptake of Graphene
81(1)
4 Strategy for Preparation
82(2)
4.1 In Situ Intercalative Polymerization
83(1)
4.2 Solution Intercalation
83(1)
4.3 Melt Intercalation
83(1)
5 Graphene-Based Polymer Composite
84(4)
5.1 Graphene Composite Paper
84(1)
5.2 Poly(3,4-Ethyldioxythiophene)/Graphene
85(1)
5.3 Epoxy/Graphene Nanocomposites
85(1)
5.4 PS/Graphene Nanocomposites
85(1)
5.5 Polyurethane/Graphene Nanocomposites
86(1)
5.6 Polyvinyl Alcohol/Graphene Nanocomposites
86(1)
5.7 Polyethylene Terephlhalate/Graphene Nanocomposites
87(1)
5.8 Polycarbonate/Graphene Nanocomposites
87(1)
5.9 Poly(Vinylidene Fluoride)/Graphene Nanocomposites
87(1)
5.10 Nafion/Graphene Nanocomposites
87(1)
5.11 Other Graphene-Based Polymer Composites
87(1)
6 Application of Graphene-Based Polymer Composite
88(12)
6.1 Electronic Devices
88(1)
6.2 Energy Storage
89(1)
6.3 Sensors
89(1)
6.4 ESD and EMI Shielding
90(1)
6.5 Biomedical Application
90(10)
7 Cellular Toxicity of Graphene
100(1)
8 Graphene: A Novel Therapeutic Agent
101(1)
8.1 Cargo Attachment
101(1)
8.2 Cell Targeting
101(1)
9 Biodistribution and Nanotoxicity of Graphene in Other Organs
102(1)
10 Conclusion
102(11)
References
102(11)
Chapter 5 Applications of Carbon Nanotubes in Drug Delivery: A Comprehensive Review
113(24)
Jashandeep Kaur
Gurlal Singh Gill
Kiran Jeet
1 Introduction
113(1)
2 Carbon Nanotubes
113(1)
3 Synthesis of CNTs
114(4)
4 Purification of CNTs
118(1)
5 Characteristics of Carbon Nanotubes
119(1)
5.1 Mechanical Properties
119(1)
5.2 Thermal Properties
119(1)
5.3 Electrical Properties
120(1)
6 Functionalization
120(2)
6.1 Covalent Bonding
120(2)
6.2 Noncovalent Bonding
122(1)
7 Applications of CNTs
122(3)
7.1 Genetic Engineering
122(1)
7.2 Biomedical Imaging
123(1)
7.3 Infection Therapy
123(1)
7.4 Artificial Implantation and Tissue Regeneration
124(1)
7.5 Catalyst
125(1)
7.6 Preservative
125(1)
7.7 Waste Water Treatment
125(1)
8 Carbon Nanotubes in Drug Delivery
125(3)
8.1 Transdermal Drug Delivery
126(1)
8.2 CNTs for Cancer Treatment
126(1)
8.3 CNTs for Cardiac Autonomic Regulation
127(1)
8.4 CNTs for Platelet Activation
127(1)
8.5 CNTs for Bioactives
128(1)
9 Conclusion and Future Recommendations
128(9)
Abbreviations
128(1)
References
128(7)
Further Reading
135(2)
Chapter 6 Nanolipid Materials for Drug Delivery Systems: A Comprehensive Review
137(28)
Jeetendra Singh Negi
1 Fatty Acids
137(4)
2 Fatty Acid Glycerides
141(4)
3 Polyethylene Glycol Derivatives of Fatty Acid Glycerides
145(2)
4 Phospholipids
147(18)
References
155(10)
Chapter 7 Nanostructure Drug Delivery System Is an Option to Solve Antimicrobial Drug Resistance: Perspective Review
165(34)
Jagadevappa S. Patil
Shivsharan B. Dhadde
Baburao N. Chandakavathe
1 Introduction
165(3)
1.1 Bacterial Resistance to Antimicrobial Agents
166(1)
1.2 Misuse of Antimicrobial Agents and Development of Microbial Resistance
167(1)
1.3 Need for Alternative Antimicrobial Drug Delivery Strategies
167(1)
2 Nanostructures for Antimicrobial Therapy
168(7)
2.1 Surface Modification of Nanocarriers for Antimicrobial Drug Therapy
170(5)
3 Pharmaceutical Nanocarriers for Antimicrobial Drug Delivery
175(13)
3.1 Liposomes for Antimicrobial Drug Delivery
176(3)
3.2 Polymeric Nanoparticles for Antimicrobial Drug Delivery
179(3)
3.3 Solid Lipid Nanoparticles for Antimicrobial Drug Delivery
182(5)
3.4 Dendrimers for Antimicrobial Drug Delivery
187(1)
4 Conclusions
188(11)
References
188(11)
Chapter 8 Protein Nanocarriers for Targeted Drug Delivery
199(20)
Leila Rezaei
Maryam Sadat Safavi
Seyed Abbas Shojaosadati
1 Introduction
199(2)
2 Animal Protein Nanocarriers
201(8)
2.1 Albumin
201(1)
2.2 Milk Proteins
202(2)
2.3 Collagen
204(1)
2.4 Gelatin
205(1)
2.5 Elastin
206(1)
2.6 Silk Proteins
207(2)
2.7 Avidin
209(1)
3 Plant Protein Nanocarriers
209(3)
3.1 Gliadin
210(1)
3.2 Soy Protein
210(1)
3.3 Zein
211(1)
3.4 Legumin
212(1)
4 Recombinant Protein Nanocarriers
212(1)
5 Conclusion
213(6)
References
213(6)
Chapter 9 Mechanism for the Nano-Based Drug Delivery System
219(46)
Kandasamy Vinothini
Mariappan Rajan
1 Introduction
219(1)
2 Physicochemical Properties of Nanocarriers and Their Effects on Biologic Systems
220(2)
2.1 Size
220(1)
2.2 Shape
221(1)
2.3 Chemical Composition
221(1)
2.4 Surface Functionalization
222(1)
3 Types of Drug Delivery Systems
222(1)
4 Controlled Delivery System
223(6)
4.1 Discovery of the Controlled Drug Delivery Systems
223(3)
4.2 Nanoemulsions Carrier for Controlled Delivery
226(2)
4.3 Disulfide Cross-Linked Shell for Noncovalently Drug-Loaded System
228(1)
4.4 Disulfide Cross-Linked Shell for Covalently Drug-Loaded System
228(1)
5 Targeted Drug Delivery
229(7)
5.1 Advantages of Targeted Drug Delivery
232(1)
5.2 Polymer Nanocarriers for Selective Release
233(1)
5.3 Mechanisms and Idea of Nanomaterial-Based Site-Targeted Controlled Release
234(1)
5.4 Nanotoxicity: Systems and Suggestions for Safe Outline of Nanomaterials
235(1)
5.5 Productivity of Cellular Drug and DDS Targeting
235(1)
6 Structural-Based Drug Delivery System
236(13)
6.1 Polymeric Micelles
236(6)
6.2 Liposome
242(2)
6.3 Niosomes
244(1)
6.4 Nanoparticle-Based Drug Delivery System
245(1)
6.5 Hydrogel-Based Drug Delivery System
246(2)
6.6 Carbon Nanotube---Based Drug Delivery System
248(1)
7 Summary
249(16)
Acknowledgments
249(1)
References
249(14)
Further Reading
263(2)
Chapter 10 Microscopy of Nanomaterial for Drug Delivery
265(16)
Adeola T. Kola-Mustapha
1 Introduction
265(1)
2 Characterization of Nanomaterials by Microscopy
266(12)
2.1 Atomic Force Microscopy
267(4)
2.2 Transmission Electron Microscopy
271(2)
2.3 Scanning Electron Microscopy
273(2)
2.4 Scanning Tunneling Microscopy
275(3)
3 Conclusion
278(3)
Acknowledgments
279(1)
References
279(2)
Chapter 11 Nanomaterials for Drug Delivery: Recent Developments in Spectroscopic Characterization
281(56)
Youcef Bal
1 Introduction
281(3)
2 Nanoparticles Characterization Techniques Overview
284(2)
3 Spectroscopic Technique Applications in Nanoparticle Characterization
286(2)
4 Vibrational Related Spectroscopies (IR and Raman)
288(9)
5 Plasmon-Enhanced Spectroscopies
297(1)
6 Surface Plasmon Resonance, Surface-Enhanced Raman Spectroscopy, and Related Techniques
297(10)
7 Magnetic Resonance Imaging
307(5)
8 Light Scattering and Diffraction Spectroscopic Methods
312(4)
8.1 Dynamic Light and Small-Angle X-ray Scattering Methods
312(3)
8.2 X-ray Diffraction
315(1)
9 Energy Dispersive X-ray Spectroscopy and X-ray Photoeleclron Spectroscopy
316(2)
10 Electron Paramagnetic Resonance Spectroscopy
318(5)
11 Conclusion
323(14)
References
324(13)
Chapter 12 Design and Characterization of Nanoparticulate Drug Delivery
337(14)
Basavaraj K. Nanjwade
Arindam Basu Sarkar
Teerapol Srichana
1 Basic Concepts of Nano
337(2)
2 Uniqueness of Nanoscale
339(2)
3 Properties of Particles at Nanoscale
341(3)
3.1 Optical Property
342(2)
4 Particle Size
344(1)
4.1 Definition of Particle Size
344(1)
5 Particle Shape
345(1)
5.1 Two-Dimensional Image
345(1)
5.2 Three-Dimensional Image
345(1)
6 Particle Density
346(1)
6.1 Definitions of Powder Density
346(1)
6.2 Measurement Methods of Powder Density
347(1)
7 Composite Structure of Nanoparticle
347(1)
8 SEM and TEM Evaluation of Nanoparticles
348(3)
References
349(2)
Chapter 13 Thermoresponsive Drug Delivery Systems, Characterization, and Applications
351(24)
Hemant K.S. Yadav
Manar Dibi
Alyazya Mohammed
Abrar Emad
1 Introduction
351(1)
2 Thermoresponsive Preparations
352(1)
3 Classification of Thermoresponsive Nanoparticles
353(15)
3.1 Micelles
353(4)
3.2 Hydrogels
357(4)
3.3 Dendrimers
361(2)
3.4 Liposomes
363(4)
3.5 Others
367(1)
4 Future Perspectives
368(1)
5 Conclusion
368(7)
References
369(6)
Chapter 14 Stimuli-Responsive Nanomaterials for Drug Delivery
375(50)
Felipe Lopez-Saucedo
Guadalupe G. Flores-Rojas
H. Ivan Melendez-Ortiz
Adriana Morfin-Gutierrez
Marco A. Luna-Straffon
Emilio Bucio
1 Introduction
375(1)
2 Synthesis of Inorganic and Polymeric NPs
375(12)
2.1 Inorganic NP Synthesis
376(4)
2.2 Polymeric NP Methods
380(7)
3 Nanocomposites
387(3)
3.1 Polymer-Based Nanocomposites
387(2)
3.2 Stimuli-Responsive Nanocomposites
389(1)
4 Metallic NPs and Applications
390(10)
4.1 Sensors and Biosensors
390(5)
4.2 Nanomedicine and Biomedical Materials
395(5)
5 Mesoporous Silica NPs
400(25)
5.1 Stimuli-Responsive Mesoporous Silica NPs
403(2)
Acknowledgments
405(1)
References
405(20)
Chapter 15 Stability Studies on Nanomaterials Used in Drugs
425(20)
Vijayakumar Selvamani
1 Background
425(2)
2 The Nanoscale of Things
427(1)
3 General Methods of Synthesis of Nanomaterials
427(2)
3.1 Top-Down Approach
427(1)
3.2 Bottom-Up Approach
428(1)
4 Synthesis of Nanoparticles
429(2)
5 Stabilization of Nanoparticles
431(1)
6 Stabilizing Agents for Nanoparticles
431(1)
7 Functionalization of Nanoparticles
432(1)
8 Theory on Stability of Nanoparticles
433(4)
8.1 Van der Waals Interaction Forces
433(2)
8.2 Electrostatic Force
435(2)
8.3 Steric Stabilization
437(1)
9 Mechanism to Check the Stability of Nanoparticles
437(8)
9.1 UV-Visible Spectroscopy
437(1)
9.2 Surface Plasmon Resonance
438(1)
9.3 Zeta Potential
438(2)
9.4 Transmission Electron Microscopy
440(1)
Acknowledgments
441(1)
References
441(4)
Chapter 16 Nano Drugs: Are They Safe? Their Toxicity and Regulatory Aspects
445(32)
Harekrishna Roy
Bhabani Shankar Nayak
Sk Abdul Rahaman
1 Introduction
445(2)
2 Nanomaterials in Drug Delivery
447(17)
2.1 Dendrimers
447(4)
2.2 Nanosized Particles
451(4)
2.3 Carbon Nanotubes
455(1)
2.4 Liposomes
456(8)
3 Regulatory Aspects
464(13)
3.1 SCENIHR
465(1)
3.2 EFSA and EMA
465(1)
3.3 SCCS
465(1)
3.4 RIPoN
466(1)
3.5 Regulatory Aspects of NMs in Agri/Feed/Food in the European Union
466(1)
3.6 Regulatory Aspects Concerning NMs in Agri/Food/Feed in Non-EU Countries
467(1)
3.7 Asian Countries
468(1)
References
469(6)
Further Reading
475(2)
Chapter 17 Nanotechnology and Nanomedicine in Market: A Global Perspective on Regulatory Issues
477(46)
Sheila Devasahayam
1 Background
477(1)
2 Objectives
478(1)
3 Scope
478(1)
4 Features of Nanotechnology
478(22)
4.1 Nanoscale Properties
479(1)
4.2 Impact of Nanoscale Properties
480(3)
4.3 Intrinsic Versus Extrinsic Nanoscale Properties
483(1)
4.4 Top-Down and Bottom-Up Nanotechnology
483(1)
4.5 Is Nanotechnology a Radical New Science?
484(1)
4.6 Impact of Interdisciplinary Nanotechnology
485(3)
4.7 Current Regulatory Regime's Response to Health, Safety, and Environmental Aspects of Nanotechnologies
488(12)
5 Nanometrology
500(2)
5.1 Nanomettology in Australia
501(1)
6 Legal Metrology Framework for Nanotechnology in Australia and Internationally
502(1)
7 Legal Metrology
502(12)
7.1 Australia's National Measurement System
504(1)
7.2 Measurement Traceability
505(1)
7.3 Elements of a Legal Metrology Control System
505(2)
7.4 Suitability of a Legal Metrology Control System to Address the Impact of Nanotechnology
507(1)
7.5 Consideration of a Legal Metrology Framework for Nanotechnology
507(7)
8 Recommendations
514(2)
9 Risks and Benefits
516(2)
10 Summary
518(5)
Acknowledgments
518(1)
References
518(5)
Chapter 18 Nano Drugs: A Critical Review of Their Patents and Market
523(30)
Sayantan Mukhopadhyay
1 Introduction
523(16)
1.1 Major Events in Nano Drug Inventions
523(16)
2 3D Nano-CAD
539(1)
3 Challenges in Scale-Up
540(1)
4 Nano Drugs in Ocular Drug Delivery
540(1)
5 Nano Drugs in the Treatment of Pulmonary Diseases
541(1)
6 Nano Drugs for Central Nervous System Diseases
541(1)
7 Nano Drugs for the Treatment of Vascular Thrombosis
541(1)
8 Nano Drugs for Gene Therapy
542(1)
9 Nanonephrology
542(1)
10 Nano Drugs for the Treatment of Cardiovascular Disease
543(1)
11 Nano Drugs for Cancer
544(3)
12 Future Opportunities and Challenges
547(6)
References
547(6)
Chapter 19 Nanobiocatalysts for Industrial Applications
553(10)
Akhilesh Kumar Shakya
Kutty Selva Nandakumar
1 Introduction
553(1)
2 Polymeric Nanobiocatalysts
554(1)
3 Magnetic Nanobiocatalysts
555(1)
4 Gold NPs
556(1)
5 Polymeric Nanofibers
557(1)
6 Carbon Nanotubes (CNTs)
558(1)
7 Sol-Gel based Nanobiocatalysts
559(1)
8 Conclusions
559(4)
Acknowledgments
559(1)
References
560(3)
Chapter 20 Nano-Based Carriers for Brain Drug Delivery
563(24)
Kivilcim Ozturk-Atar
Muge Yemisci Ozkan
Hakan Eroglu
Yilmaz Qapan
1 Introduction
563(2)
2 Biologic Aspects of the CNS
565(1)
3 Blood---Brain Barrier
566(1)
4 P-Glycoprotein
567(1)
5 Transferrin Receptor in Brain Capillary Endothelial Cells
568(1)
6 Nanocarrier Implementation
568(2)
6.1 Size and Charge Optimization
569(1)
6.2 Surface Modifications
569(1)
6.3 PEGylation
569(1)
6.4 Surfactants
570(1)
6.5 Targeting
570(1)
6.6 Imaging Agents
570(1)
7 Strategies for CNS Drug Delivery
570(1)
8 Local or Systemic Delivery?
571(1)
9 Invasive Strategies for CNS Drug Delivery
572(1)
9.1 Disruption of the BBB
572(1)
9.2 Direct Injection Into CNS
572(1)
10 Noninvasive Strategies for CNS Drug Delivery
573(1)
11 Drug Transport Mechanisms of BBB
573(3)
11.1 Passive Diffusion (Transmembrane Diffusion)
573(2)
11.2 Carrier/Transporter-Mediated Transport
575(1)
11.3 Active Efflux Transporters
575(1)
11.4 Receptor-Mediated Transport
575(1)
12 Targeting Perspectives for Brain Drug Delivery
576(1)
13 Other Delivery Approaches
577(2)
13.1 Chimeric Peptide Technology
577(1)
13.2 BBB Transport of Small Molecules Is Limited
578(1)
14 Nanopharmaceutical Approaches for CNS Drug Delivery
579(1)
15 Brain Tumors
580(1)
16 Ischemic Stroke
581(1)
17 Neurodegenerative Disorders: Alzheimer Disease and Parkinson Disease
582(1)
18 An Important Point to Consider: Neurotoxicity Potential of Nanocarriers
583(1)
19 Future Perspectives and Conclusions
583(4)
References
584(3)
Chapter 21 Administration Routes for Nano Drugs and Characterization of Nano Drug Loading
587(40)
Vesna Nikolic
Snezana Ilic-Stojanovic
Sanja Petrovic
Ana Tabic
Ljubisa Nikolic
1 Introduction
587(1)
2 Polymeric Nanoparticles
587(5)
2.1 Oral Administration Route
588(2)
2.2 Transdermal Administration Route
590(1)
2.3 Nasal Administration Route
590(1)
2.4 Ocular Administration Route
590(1)
2.5 Pulmonary Administration Route
591(1)
2.6 Parenteral Administration Route
591(1)
3 Dendrimers
592(5)
3.1 Drug-Loading Dendrimer Administration Routes
592(1)
3.2 Oral Drug Delivery
593(1)
3.3 Transdermal Drug Delivery
594(1)
3.4 Ocular Drug Delivery
594(1)
3.5 Pulmonary Drug Administration
595(1)
3.6 Parenteral Drug Administration
596(1)
3.7 Dendrimer Advantages and Disadvantages
596(1)
4 Liposomes
597(4)
4.1 Enteral/Gastroenteric Administration
598(1)
4.2 Parenteral Administration
598(2)
4.3 Topical Administration
600(1)
4.4 Pulmonary Administration
600(1)
5 Cyclodextrin-Based Nanocarriers
601(7)
5.1 Cyclodextrin Applications
602(2)
5.2 Ocular Administration Route
604(2)
5.3 Nasal Administration Route
606(1)
5.4 Transdermal Administration Route
606(1)
5.5 Oral Administration Route
607(1)
5.6 Pulmonary Administration Route
607(1)
6 Characterization of Nanoparticular Systems
608(4)
6.1 Zeta Potential
608(1)
6.2 High-Pressure Liquid Chromatography
608(1)
6.3 The Efficiency of Drug Incorporation/Encapsulation
609(1)
6.4 Particle Size
610(1)
6.5 Differential Scanning Calorimetry
610(1)
6.6 Nuclear Magnetic Resonance
610(1)
6.7 IR Spectroscopy
611(1)
6.8 X-Ray Diffraction
611(1)
6.9 Microscopy
611(1)
6.10 Mass Spectrometry
612(1)
7 Conclusion
612(15)
Acknowledgment
613(1)
References
613(11)
Further Reading
624(3)
Index 627
Shyam Mohapatra is Distinguished USF Health Professor, Director of the Division of Translational Medicine at the University of South Florida. He also directs the USF Center for Research and Education in Nanobioengineering and is a Research Career Scientist at the James A. Haley VA Hospital in Tampa. He also serves as Associate Dean of Graduate Programs at the USF College of Pharmacy, and established a highly innovative Master of Science program in Pharmaceutical Nanotechnology. He has published over 170 papers and holds over 30 U.S. and international patents. He is a Fellow of the AAAAI, NAI, and AIMBE, and a 2014 inductee of the Florida Inventors Hall of Fame. Dr. Shivendu Ranjan has extensive expertise in Micro/Nanotechnology and is currently working as Head R&D and Technology Development at E-Spin Nanotech Pvt. Ltd. He has founded and drafted the concept for the first edition of the VIT Bio Summit” in 2012, and the same has been continued till date by the university. He has worked in CSIR-CFTRI, Mysuru, India as well as UP Drugs and Pharmaceutical Co. Ltd., India and IIFPT, Thanjavur, MoFPI, Govt of India. At IIFPT, Thanjavur, he was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. His research interests are multidisciplinary and include: Micro/Nanobiotechnology, Nano-toxicology, Environmental Nanotechnology, Nanomedicine, and Nanoemulsions. . He is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and an editorial board member in Biotechnology and Biotechnological Equipment(Taylor and Francis). He is serving as executive editor of a journal in iMed Press, USA, and also serving as editorial board member and referee for reputed international peer-reviewed journals. He is the author of many books and edited six books. Dr. Nandita Dasgupta has vast working experience in Micro/Nanoscience and is currently working at LV Prasad Eye Institute, Bhubaneswar, India. She has exposure of working at university, research institutes and industries including VIT University, Vellore, Tamil Nadu, India; CSIR-Central Food Technological Research Institute, Mysore, India; and Uttar Pradesh Drugs and Pharmaceutical Co. Ltd., Lucknow, India and Indian Institute of Food Processing Technology (IIFPT), Thanjavur, Ministry of Food Processing Industries, Government of India. At IIFPT, Thanjavur, she was involved in a project funded by a leading pharmaceutical company, Dr. Reddys Laboratories and have successfully engineered micro-vehicles for model drug molecules. Her areas of interest include Micro/Nanomaterial fabrication and its applications in various fields medicine, food, environment, agriculture biomedical. She is the author os many books and edited more than 6 books. She has authored many chapters and also published many scientific articles in international peer-reviewed journals. She has received the Certificate for Outstanding Contribution” in Reviewing from Elsevier, Netherlands. She has also been nominated for advisory panel for Elsevier Inc., Netherlands. She is the associate editor of Environmental Chemistry Letters a Springer journal of 3.59 impact factor and also serving as editorial board member and referee for reputed international peer-reviewed journals. She has received several awards and recognitions from different national and international organizations. Dr. Sabu Thomas (Ph.D.) is the Director of the School of Energy Materials, School of Nanoscience and Nanotechnology of Mahatma Gandhi University, India. He received his Ph. D. in 1987 in Polymer Engineering from the Indian Institute of Technology (IIT), Kharagpur, India. He is a fellow of the Royal Society of Chemistry, London, and a member of the American Chemical Society. He has been ranked no.1 in India about the number of publications (most productive scientists). Prof. Thomass research group specialized areas of polymers which includes Polymer blends, Fiber filled polymer composites, Particulate-filled polymer composites and their morphological characterization, Ageing and degradation, Pervaporation phenomena, sorption and diffusion, Interpenetrating polymer systems, Recyclability and reuse of waste plastics and rubbers, Elastomer cross-linking, Dual porous nanocomposite scaffolds for tissue engineering, etc. Prof. Thomass research group has extensive exchange programs with different industries, research, and academic institutions all over the world and is performing world-class collaborative research in various fields. Professors Centre is equipped with various sophisticated instruments and has established state-of-the-art experimental facilities which cater to the needs of researchers within the country and abroad. His H Index- 133, Google Citations- 86424, Number of Publications- 1300, and Books-160.

Raghvendra Kumar Mishra is a Materials Scientist in the Chemical Engineering Department at IIT Delhi, India, and he has previously held research positions at Cranfield University (United Kingdom), Madrid Institute of Advanced Studies (Spain), and Mahatma Gandhi University (India). His research interests focus on nanomaterials and polymer composites, including new applications of nanomaterials, developing nanomaterials-based systems for diverse functionalities, creating biopolymer-based composites, and utilizing advanced fabrication techniques such as electrospinning and 3D printing.