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Fasciolosis 2nd edition [Kõva köide]

Edited by (National University of Ireland Galway, Ireland)
  • Formaat: Hardback, 520 pages, kõrgus x laius x paksus: 244x172x30 mm, kaal: 1417 g
  • Ilmumisaeg: 20-Dec-2021
  • Kirjastus: CABI Publishing
  • ISBN-10: 1789246164
  • ISBN-13: 9781789246162
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Fasciolosis 2nd editionSuurem pilt
  • Formaat: Hardback, 520 pages, kõrgus x laius x paksus: 244x172x30 mm, kaal: 1417 g
  • Ilmumisaeg: 20-Dec-2021
  • Kirjastus: CABI Publishing
  • ISBN-10: 1789246164
  • ISBN-13: 9781789246162
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Märksõnad:
Fasciolosis is a major global infection of livestock causing both huge losses to the agricultural community and affecting human health as a food-borne disease. Fully updated throughout, this new edition continues to cover the life cycle, biology, and development of the parasite; clinical pathology, immunology, diagnosis and vaccine development; and emergence, cause and mechanisms of drug resistance. It reviews the temperate liver fluke Fasciola hepatica, together with molecular, biochemical, control, and epidemiologial aspects of the tropical liver fluke F. gigantica. Many fundamental advances have taken place in the last two decades, but of particular importance has been the mapping of the draft genome of Fasciola. In addition, comprehensive advances in transcriptomics, proteomics and glycomics have been made, and the book therefore pays particular attention to these developments with the addition of brand-new chapters. Also covering the impact these parasites have had on the global human population, their distribution and their ecology, this book provides a comprehensive and accessible resource for scientists, researchers and students of medical and veterinary parasitology.

Muu info

Suitable for scientists, researchers and students of medical and veterinary parasitology.
Contributors ix
Preface xiii
Acknowledgements xv
1 The Discovery of Fasciola hepatica and its Life Cycle
1(22)
Stuart J. Andrews
Krystyna Cwiklinski
John Pius Dalton
1.1 Introduction
1(1)
1.2 The Discovery of the Life Cycle
2(3)
1.3 The Life Cycle
5(10)
References
15(8)
2 Fasciola hepatica Larval Development Within the Intermediate Host
23(42)
Gilles Dreyfuss
Philippe Slndou
Philippe Hourdin
Philippe Vignoles
Daniel Rondelaud
2.1 Introduction
23(1)
2.2 Snail Hosts of Fasciola hepatica
23(2)
2.3 Dynamics of Larval Forms Within the Snail
25(7)
2.4 Cercarial Shedding of Fasciola hepatica
32(4)
2.5 Snail Infection by the Parasite
36(12)
2.6 Snail Co-infections
48(2)
2.7 Consequences of Parasitism on the Snail
50(2)
References
52(13)
3 Development of Fasciola hepatica in the Mammalian Host
65(47)
Mark W. Robinson
Robert E.B. Hanna
Ian Fairweather
3.1 Introduction
65(1)
3.2 Tegument
65(14)
3.3 Parenchyma
79(4)
3.4 Muscle
83(1)
3.5 Nervous System
84(4)
3.6 Cytoskeleton
88(3)
3.7 Gut
91(4)
3.8 Excretory System
95(4)
3.9 In vitro Models of Fluke Infection
99(2)
3.10 Conclusions and Future Perspectives
101(1)
Acknowledgements
102(1)
References
102(10)
4 The Reproductive System of Fasciola hepatica
112(33)
Robert E. B. Hanna
Lan Fairweather
Mark W. Robinson
4.1 Introduction
112(1)
4.2 Arrangement of Gonads, Accessory Organs and Ducts
113(1)
4.3 Development of the Reproductive System
114(1)
4.4 Male Reproductive System
115(8)
4.5 Female Reproductive System
123(10)
4.6 The Egg
133(7)
4.7 Conclusions and Future Perspectives
140(1)
Acknowledgements
140(1)
References
141(4)
5 Pathology, Pathophysiology and Clinical Aspects
145(35)
Nicholas C. Sangster
Alvaro Martinez-Moreno
Jose Perez
5.1 Pathology
145(9)
5.2 Clinical Aspects
154(2)
5.3 Pathophysiology and Metabolic Aspects
156(4)
5.4 Pathogenesis
160(5)
5.5 Fasciola and its Host
165(4)
5.6 Conclusions
169(1)
References
169(11)
6 Epidemiology and Control
180(31)
Gabriela Knubben-Schweizer
Anne-Sophie Rossler
Eva Schade-Weskott
Paul R. Torgerson
6.1 Introduction
180(1)
6.2 Parasite, Host and Intermediate Host Species
180(2)
6.3 The Effects of Climate and Environment on Fasciola spp.
182(4)
6.4 Effects of Climate Change
186(1)
6.5 Management Factors Affecting Transmission
186(1)
6.6 Other Effects on Transmission
187(1)
6.7 Resistance to Fasciolosis in Livestock
188(1)
6.8 Economic Effects of Fasciolosis in Livestock
189(1)
6.9 Control Options for Fasciolosis
190(5)
6.10 Risk Maps, Models and Forecasting Systems
195(6)
6.11 Conclusions
201(1)
References
201(10)
7 Flukicidal Drugs: Pharmaco-therapeutics and Drug Resistance
211(45)
Luis I. Alvarez
Carlos E. Lanusse
Diana J.L. Williams
Ian Fairweather
Jane E. Hodgkinson
7.1 Introduction
211(1)
7.2 Pharmaco-therapeutics
211(9)
7.3 Flukicide Pharmacokinetics
220(4)
7.4 Mechanisms of Drug Entry into Adult Liver Flukes
224(3)
7.5 Flukicide Resistance
227(12)
7.6 Mechanism(s) of Resistance
239(3)
7.7 Concluding Remarks
242(1)
Acknowledgement
243(1)
References
243(13)
8 Metabolism
256(22)
Aloysius G.M. Tielens
Jaap J. van Hellemond
8.1 Introduction
256(1)
8.2 Nutrition
256(1)
8.3 Energy Metabolism
257(13)
8.4 Biosynthetic Capacities
270(1)
8.5 Lipid Metabolism
270(2)
8.6 Protein Metabolism
272(1)
8.7 Concluding Remarks
272(1)
Acknowledgement
273(1)
References
273(5)
9 Immunological Interaction Between Fasciola and its Host
278(1)
Sheila Donnelly
Robin Flynn
Grace Mulcahy
Sandra O'Neill
9.1 Introduction
278(1)
9.2 Infection in the Natural Host
279(5)
9.3 Infection in Experimental Hosts
284(4)
9.4 Bystander Effects of Fasciola hepatica Infection
288(1)
9.5 Therapeutic Potential of Fasciola hepatica-derived Molecules
289(6)
9.6 Conclusions and Future Directions
295(4)
References
299(9)
10 Diagnostics for Animal and Human Fasciolosis
308(30)
Florencio M. Ubeira
Victoria Martinez-Sernandez
Marta Gonzalez-Warleta
Mercedes Mezo
10.1 Introduction
308(1)
10.2 Methods for Diagnosis of Fasciolosis at the Early Stage of Infection
309(7)
10.3 Diagnosis During the Early Biliary and Chronic Phases of Infection
316(6)
10.4 Detection of Ova in Stools by Microscopy
322(2)
10.5 Diagnosis by Molecular Techniques
324(1)
10.6 Adaptations and Complementary Diagnostic Methods
325(2)
10.7 Concluding Remarks
327(1)
Acknowledgements
327(1)
References
328(10)
11 Applying `Omics' Technologies to Understand Fasciola spp. Biology
338(1)
Krystyna Cwiklinski
Carolina De Marco Verissimo
Paul McVeigh
Sheila Donnelly
John P. Dalton
11.1 Introduction
338(2)
11.2 The Mitochondrial and Nuclear Genomes
340(4)
11.3 Transcriptomics and Stage-specific Gene Expression
344(5)
11.4 Non-coding RNAs
349(4)
11.5 Proteomics Identify Proteins in Parasite-Host Interactions
353(4)
11.6 Extracellular Vesicles
357(3)
11.7 Glycomics Identify Sugars in Parasite-Host Interactions
360(4)
11.8 Proteomic and Transcriptomic Analyses of Host Responses to F. hepatica
364(2)
11.9 Concluding Remarks
366(1)
References
367(12)
12 Vaccines for Fasciola: New Thinking for an Old Problem
379(1)
Terry W. Spithill
Hayley Toet
Vignesh Rathinasamy
Gemma Zerna
Jaclyn Swan
Timothy Cameron
Peter M. Smooker
David M. Piedrafita
Robert Dempster
Travis Beddoe
12.1 Introduction
379(1)
12.2 Recent Vaccine Studies in Livestock (2014-2020)
380(5)
12.3 A Potential Way Forward
385(1)
12.4 Identifying New Protein Vaccine Candidates on the Surface Tegument of Juvenile Flukes
386(1)
12.5 Potential Mechanisms of Immunity Against Fasciola hepatica
387(3)
12.6 Glycans and Glycoconjugates as Vaccine Targets
390(2)
12.7 Whole Exosomes, Exosome Extracts and Exosome Antigens as Vaccines
392(3)
12.8 New Adj uvants to Enhance Liver Fluke Vaccine Efficacy
395(5)
12.9 Assessing Liver Fluke Vaccine Efficacy in Cattle Based on Reduction in Intensity of Fluke Burden
400(7)
12.10 Commercial Considerations in Liver Fluke Vaccine Development
407(3)
12.11 References
410(13)
13 Fasciola gigantica and Fasciola Hybrids in Southeast Asia
423(38)
Nichola Eliza Davies Calvani
Jan Slapeta
13.1 Introduction
423(1)
13.2 Fasciola gigantica Life Cycle
424(10)
13.3 Production and Economic Impacts of Fasciolosis in Southeast Asia
434(4)
13.4 Control of Fasciola gigantica
438(1)
13.5 Diagnosis in the Developing World
439(3)
13.6 Genetic Characterization of F. gigantica and Fasciola Hybrids
442(2)
13.7 Zoonosis
444(2)
13.8 Future Directions for E gigantica Research
446(1)
References
447(14)
14 Global Impact of Human Fasciolosis
461(32)
Preetam Gandhi
Richa Chandra
Esther K. Schmitt
Chien-Wei Chen
Sanjay Samantray
Vinay Kumar Venishetty
David Hughes
14.1 Introduction
461(1)
14.2 Epidemiology
461(3)
14.3 Pathology in the Human Host
464(8)
14.4 Treatment of Human Fasciolosis
472(9)
14.5 Future Prospects
481(2)
References
483(10)
Index 493
Professor John Dalton graduated from University College Dublin with a PhD in Molecular Parasitology, before becoming a Postdoctoral Research Fellow working on schistosomes at the Johns Hopkins School of Medicine, then malaria at the National Institute of Allergies and Infectious Diseases in Bethesda, USA. He briefly returned to Ireland as a lecturer at Dublin City University, before taking Director level roles at the University of Technology Sydney in Australia, and later McGill University, Canada. Returning home in 2013, he became the Professor in Infectious Diseases at Queens University of Belfast, Northern Ireland, and since 2019 has taken the role of Science Foundation Ireland (SFI) Professor in Molecular Parasitology at the National University of Ireland Galway.