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Fluorescent Nanodiamonds [Kõva köide]

  • Formaat: Hardback, 304 pages, kõrgus x laius x paksus: 246x175x20 mm, kaal: 726 g
  • Ilmumisaeg: 16-Nov-2018
  • Kirjastus: John Wiley & Sons Inc
  • ISBN-10: 1119477085
  • ISBN-13: 9781119477082
Teised raamatud teemal:
  • Formaat: Hardback, 304 pages, kõrgus x laius x paksus: 246x175x20 mm, kaal: 726 g
  • Ilmumisaeg: 16-Nov-2018
  • Kirjastus: John Wiley & Sons Inc
  • ISBN-10: 1119477085
  • ISBN-13: 9781119477082
Teised raamatud teemal:

The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications

Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology.

Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. 

  • The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields
  • Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives
  • Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs
  • The first book published by the key patent holder with his research group in the field of FNDs

Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.

Preface xi
Acknowledgements xv
Part I Basics
1(90)
1 Introduction to Nanotechnology
3(16)
1.1 Nanotechnology: From Large to Small
3(5)
1.1.1 Feynman: Plenty of Room at the Bottom
3(3)
1.1.2 Nanotechnology Today
6(1)
1.1.3 The Bottom-Up Approach
7(1)
1.2 Nanocarbons: Now and Then
8(11)
1.2.1 Classification
9(1)
1.2.2 Fullerenes
9(2)
1.2.3 Carbon Nanotubes
11(2)
1.2.4 Graphenes
13(2)
References
15(4)
2 Nanodiamonds
19(18)
2.1 Ah, Diamonds, Eternal Beautiful
19(3)
2.2 Diamonds: From Structure to Classification
22(4)
2.2.1 Structure
22(2)
2.2.2 Classification
24(2)
2.3 Diamond Synthesis
26(4)
2.3.1 HPHT
27(2)
2.3.2 CVD
29(1)
2.3.3 Detonation
30(1)
2.4 Nanodiamonds: A Scientist's Best Friend
30(7)
References
33(4)
3 Color Centers in Diamond
37(18)
3.1 Nitrogen Impurities
37(3)
3.2 Crystal Defects
40(1)
3.3 Vacancy-Related Color Centers
41(6)
3.3.1 GR1 and ND1
41(3)
3.3.2 NV0 and NV-
44(2)
3.3.3 H3 and N3
46(1)
3.3.4 SiV-
46(1)
3.4 The NV- Center
47(8)
References
50(5)
4 Surface Chemistry of Nanodiamonds
55(18)
4.1 Functionalization
56(5)
4.2 Bioconjugation
61(5)
4.2.1 Noncovalent Conjugation
61(3)
4.2.2 Covalent Conjugation
64(2)
4.3 Encapsulation
66(7)
4.3.1 Lipid Layers
66(1)
4.3.2 Silica Shells
67(2)
References
69(4)
5 Biocompatibility of Nanodiamonds
73(18)
5.1 Biocompatibility Testing
73(4)
5.1.1 Cytotoxicity
74(2)
5.1.2 Genotoxicity
76(1)
5.1.3 Hemocompatibility
76(1)
5.2 In Vitro Studies
77(5)
5.2.1 HPHT-ND
77(3)
5.2.2 DND
80(2)
5.3 Ex Vivo Studies
82(1)
5.4 In Vivo Studies
83(8)
References
86(5)
Part II Specific Topics
91(180)
6 Producing Fluorescent Nanodiamonds
93(20)
6.1 Production
93(8)
6.1.1 Theoretical Simulations
93(3)
6.1.2 Electron/Ion Irradiation
96(3)
6.1.3 Size Reduction
99(2)
6.2 Characterization
101(12)
6.2.1 Fluorescence Intensity
101(3)
6.2.2 Electron Spin Resonance
104(1)
6.2.3 Fluorescence Lifetime
105(2)
6.2.4 Magnetically Modulated Fluorescence
107(3)
References
110(3)
7 Single Particle Detection and Tracking
113(622)
7.1 Single Particle Detection
113(7)
7.1.1 Photostability
113(4)
7.1.2 Spectroscopic Properties
117(1)
7.1.3 Color Center Numbers
118(2)
7.2 Single Particle Tracking
120(615)
7.2.1 Tracking in Solution
120(2)
7.2.2 Tracking in Cells
122(5)
7.2.3 Tracking in Organisms
127(3)
References
130(605)
8 Cell Labeling and Fluorescence Imaging
735(20)
8.1 Cell Labeling
135(7)
8.1.1 Nonspecific Labeling
136(3)
8.1.2 Specific Labeling
139(3)
8.2 Fluorescence Imaging
142(613)
8.2.1 Epifluorescence and Confocal Fluorescence
142(2)
8.2.2 Total Internal Reflection Fluorescence
144(2)
8.2.3 Two-Photon Excitation Fluorescence
146(1)
8.2.4 Time-Gated Fluorescence
147(3)
References
150(605)
9 Cell Tracking and Deep Tissue Imaging
155(1)
9.1 Cellular Uptake
155(1)
9.1.1 Uptake Mechanism
155(3)
9.1.2 Entrapment
158(601)
9.1.3 Quantification
159(2)
9.2 Cell Tracking
161(4)
9.2.1 Tracking In Vitro
161(2)
9.2.2 Tracking In Vivo
163(2)
9.3 Deep Tissue Imaging
165(5)
9.3.1 Wide-Field Fluorescence Imaging
165(4)
9.3.2 Optically Detected Magnetic Resonance Imaging
169(1)
9.3.3 Time-Gated Fluorescence Imaging
170(1)
93 A Magnetically Modulated Fluorescence Imaging
170(605)
References
171(604)
10 Nanoscopic Imaging
775(20)
10.1 Diffraction Barrier
176(1)
10.2 Superresolution Fluorescence Imaging
177(7)
10.2.1 Stimulated Emission Depletion Microscopy
177(4)
10.2.2 Saturated Excitation Fluorescence Microscopy
181(1)
10.2.3 Deterministic Emitter Switch Microscopy
182(1)
10.2.4 Tip-Enhanced Fluorescence Microscopy
183(1)
10.3 Cathodoluminescence Imaging
184(4)
10.4 Correlative Light-Electron Microscopy
188(3)
References
191(4)
11 Nanoscale Quantum Sensing
195(1)
11.1 The Spin Hamiltonian
196(1)
11.2 Temperature Sensing
197(1)
11.2.1 Ultrahigh Precision Temperature Measurement
197(3)
11.2.2 Time-Resolved Nanothermometry
200(3)
11.2.3 All-Optical Luminescence Nanothermometry
203(2)
11.2.4 Scanning Thermal Imaging
205(2)
11.3 Magnetic Sensing
207(8)
11.3.1 Continuous-Wave Detection
207(3)
11.3.2 Relaxometry
210(1)
References
211(4)
12 Hybrid Fluorescent Nanodiamonds
215(20)
12.1 Silica/Diamond Nanohybrids
215(2)
12.2 Gold/Diamond Nanohybrids
217(9)
12.2.1 Photoluminescence Enhancement
217(1)
12.2.2 Dual-Modality Imaging
218(2)
12.2.3 Hyperlocalized Hyperthermia
220(4)
12.2.4 NV-Based Nanothermometry
224(2)
12.3 Silver/Diamond Nanohybrids
226(2)
12.4 Iron Oxide/Diamond Nanohybrids
228(7)
12.4.1 Single-Domain Magnetization
228(1)
12.4.2 Magnetic Resonance Imaging
229(3)
References
232(3)
13 Nanodiamond-Enabled Medicine
235(18)
13.1 NDs as Therapeutic Carriers
236(1)
13.2 Drug Delivery
237(7)
13.2.1 Small Molecules
237(4)
13.2.2 Proteins
241(3)
13.3 Gene Therapy
244(3)
13.3.1 RNA
244(1)
13.3.2 DNA
245(2)
13.4 Animal Experiments
247(6)
References
249(4)
14 Diamonds in the Sky
253(18)
14.1 Unidentified Infrared Emission
253(5)
14.2 Extended Red Emission
258(6)
14.3 Cosmic Events at Home on Earth
264(7)
References
267(4)
Further Reading 271(2)
Index 273
Huan-Cheng Chang, PhD, Distinguished Research Fellow, Institute of Atomic and Molecular Sciences (IAMS), Academia Sinica, Taipei, Taiwan, Republic of China. Academia Sinica is the national academy of the Republic of China.

Wesley Wei-Wen Hsiao, PhD, LLM is CEO of FND Biotech, Inc., Taipei, Taiwan, Republic of China.

Meng-Chih Su, PhD, Professor in Chemistry, Sonoma State University (SSU), Rohnert Park, California, USA. Dr. Su has served as Department Chair for the Chemistry Department and later the Engineering Science Department at SSU.