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Introduction to Statistical Methods in Modern Genetics [Pehme köide]

(University of Florida, Gainesville, USA)
  • Formaat: Paperback / softback, 260 pages, kõrgus x laius: 229x152 mm, kaal: 453 g
  • Sari: Modern Analysis Series
  • Ilmumisaeg: 05-Sep-2019
  • Kirjastus: CRC Press
  • ISBN-10: 0367398907
  • ISBN-13: 9780367398903
Teised raamatud teemal:
  • Formaat: Paperback / softback, 260 pages, kõrgus x laius: 229x152 mm, kaal: 453 g
  • Sari: Modern Analysis Series
  • Ilmumisaeg: 05-Sep-2019
  • Kirjastus: CRC Press
  • ISBN-10: 0367398907
  • ISBN-13: 9780367398903
Teised raamatud teemal:
Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application.

Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn:

How a gene is found

How scientists have separated the genetic and environmental aspects of a person's intelligence

How genetics are used in agriculture to improve crops and domestic animals

What a DNA fingerprint is and why there are controversies about it

Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entrée into the rapidly expanding world of genetic data analysis.
Introduction to the Series vii
Preface ix
Notations xi
1 Background to Modern Statistical Genetics
1(42)
1.1 Introduction: Where is the Gene?
1(4)
1.2 Function of Genes in Reproduction
5(9)
1.3 Some Facts in Molecular Genetics
14(8)
1.4 Tools in Molecular Genetics
22(8)
1.5 Genetic Engineering
30(9)
Exercise 1
39(4)
2 Linkage Analysis with Qualitative Trait
43(54)
2.1 Basic Concepts in Pedigree Analysis
43(10)
2.2 Linkage Analysis for Large Pedigrees
53(12)
2.3 Incomplete Penetrance and Sibling Studies
65(17)
2.4 Designs in Linkage Analysis
82(10)
Exercise 2
92(5)
3 Genetics of Quantitative Trait
97(60)
3.1 Quantitative Trait Locus (QTL) Based on Sibpairs
97(10)
3.2 Interval Mapping of Quantitative Trait Loci
107(19)
3.3 Heritability Estimation
126(14)
3.4 Breeding Value Evaluation Models
140(14)
Exercise 3
154(3)
4 Special Topics
157(38)
4.1 Small Area Gene Mapping by Linkage Disequilibrium
157(9)
4.2 Gene, Exon and Intron Identification
166(6)
4.3 Reconstruction of Evolutionary Path
172(10)
4.4 Forensic Evidence Using Genetic Markers
182(10)
Exercise 4
192(3)
Appendix A Statistical Results Useful in Genetics
195(18)
A.1 Multivariate Analysis and Regression
195(4)
A.2 Likelihood Ratio Test and General Linear Models
199(5)
A.3 Multinomial Distribution
204(2)
A.4 Inference on Frequency Tables
206(2)
A.5 Discriminant Analysis and Neural Network
208(5)
Appendix B Selected Public Domain Computer Programs for Genetic Data Analysis
213(14)
B.1 A Teaching Linkage Analysis Program for Two Generation Families
213(4)
B.2 A Simulation Program to Compute ELOD and Var(LOD) for Two Generation Families
217(2)
B.3 Liped and Programs Described in Terwilliger and Ott's Handbook
219(1)
B.4 Simlink---Power Prediction for Given Pedigrees
220(1)
B.5 Sib-Pair: A Nonparametric Linkage Software
221(1)
B.6 Mapmaker/Sibs, Mapmaker/Qtl, Genehunter, GAS (Genetic Analysis System)
222(1)
B.7 A SAS Program to Compute Kinships Coefficients
223(1)
B.8 Using SAS-IML to Solve Henderson's Equation
224(1)
B.9 ETDT (Extended Transmission Disequilibrium Test)
225(1)
B.10 GeneBank and Genetic Data Sources
225(2)
Answers or Hints to Exercises 227(6)
Bibliography 233(12)
Index 245