Introduction to the Series |
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vii | |
Preface |
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ix | |
Notations |
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xi | |
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1 Background to Modern Statistical Genetics |
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1 | (42) |
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1.1 Introduction: Where is the Gene? |
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1 | (4) |
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1.2 Function of Genes in Reproduction |
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5 | (9) |
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1.3 Some Facts in Molecular Genetics |
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14 | (8) |
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1.4 Tools in Molecular Genetics |
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22 | (8) |
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30 | (9) |
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39 | (4) |
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2 Linkage Analysis with Qualitative Trait |
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43 | (54) |
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2.1 Basic Concepts in Pedigree Analysis |
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43 | (10) |
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2.2 Linkage Analysis for Large Pedigrees |
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53 | (12) |
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2.3 Incomplete Penetrance and Sibling Studies |
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65 | (17) |
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2.4 Designs in Linkage Analysis |
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82 | (10) |
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92 | (5) |
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3 Genetics of Quantitative Trait |
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97 | (60) |
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3.1 Quantitative Trait Locus (QTL) Based on Sibpairs |
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97 | (10) |
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3.2 Interval Mapping of Quantitative Trait Loci |
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107 | (19) |
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3.3 Heritability Estimation |
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126 | (14) |
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3.4 Breeding Value Evaluation Models |
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140 | (14) |
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154 | (3) |
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157 | (38) |
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4.1 Small Area Gene Mapping by Linkage Disequilibrium |
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157 | (9) |
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4.2 Gene, Exon and Intron Identification |
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166 | (6) |
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4.3 Reconstruction of Evolutionary Path |
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172 | (10) |
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4.4 Forensic Evidence Using Genetic Markers |
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182 | (10) |
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192 | (3) |
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Appendix A Statistical Results Useful in Genetics |
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195 | (18) |
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A.1 Multivariate Analysis and Regression |
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195 | (4) |
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A.2 Likelihood Ratio Test and General Linear Models |
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199 | (5) |
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A.3 Multinomial Distribution |
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204 | (2) |
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A.4 Inference on Frequency Tables |
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206 | (2) |
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A.5 Discriminant Analysis and Neural Network |
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208 | (5) |
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Appendix B Selected Public Domain Computer Programs for Genetic Data Analysis |
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213 | (14) |
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B.1 A Teaching Linkage Analysis Program for Two Generation Families |
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213 | (4) |
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B.2 A Simulation Program to Compute ELOD and Var(LOD) for Two Generation Families |
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217 | (2) |
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B.3 Liped and Programs Described in Terwilliger and Ott's Handbook |
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219 | (1) |
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B.4 Simlink---Power Prediction for Given Pedigrees |
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220 | (1) |
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B.5 Sib-Pair: A Nonparametric Linkage Software |
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221 | (1) |
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B.6 Mapmaker/Sibs, Mapmaker/Qtl, Genehunter, GAS (Genetic Analysis System) |
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222 | (1) |
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B.7 A SAS Program to Compute Kinships Coefficients |
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223 | (1) |
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B.8 Using SAS-IML to Solve Henderson's Equation |
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224 | (1) |
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B.9 ETDT (Extended Transmission Disequilibrium Test) |
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225 | (1) |
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B.10 GeneBank and Genetic Data Sources |
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225 | (2) |
Answers or Hints to Exercises |
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227 | (6) |
Bibliography |
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233 | (12) |
Index |
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245 | |