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E-raamat: Mass Spectrometry Handbook

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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Arvustused

In summary, this handbook presents research from a variety of areas tied together by the common thread of mass spectrometry. The authors present their works in a manner that is accessible to beginning researchers and include sufficient references to allow in depth exploration of the topic. More seasoned scientists could also benefit from this book as they venture into new areas of research.  (Journal of American Society for Mass Spectrometry, 6 October 2012)

Foreword xi
Preface xiii
Contributors xvii
SECTION I BIOTECHNOLOGY/PROTEINS
1(106)
1 Targeted Proteomics Using Immunoaffinity Purification
3(20)
Karen R. Jonscher
Lei Jin
John C. Cambier
Shaikh M. Rahman
Jacob E. Friedman
2 Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifications by Lipid Peroxidation Products
23(18)
Navin Rauniyar
Laszlo Prokai
3 Imaging Mass Spectrometry (IMS) for Biological Application
41(44)
Yuki Sugiura
Ikuko Yao
Mitsutoshi Setou
4 Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAs
85(22)
George W. Jackson
Rafal Drabek
Mithil Soni
Roger McNichols
Richard C. Willson
George E. Fox
SECTION II PHARMACEUTICAL
107(164)
5 Preclinical Pharmacokinetics: Industrial Perspective
109(10)
Ayman El-Kattan
Manthena Varma
6 LC-MS in Drug Metabolism and Pharmacokinetics: A Pharmaceutical Industry Perspective
119(52)
Wenying Jian
Wilson Shou
Richard W. Edom
Naidong Weng
Mingshe Zhu
7 Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies
171(20)
Xiaoying Xu
Wenkui Li
Francis L.S. Tse
8 Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS
191(18)
Margret Thorsteinsdottir
Baldur Bragi Sigurosson
Gisli Bragason
9 Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS
209(18)
Kevin A. Schug
10 Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products
227(16)
Igor A. Kaltashov
Cedric E. Bobst
Rinat R. Abzalimov
11 TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods
243(16)
Satoka Aoyagi
12 Accelerator Mass Spectrometry in Pharmaceutical Development
259(12)
Benjamin J. Stewart
Graham Bench
Bruce A. Buchholz
Kurt W. Haack
Michael A. Malfatti
Ted J. Ognibene
Kenneth W. Turteltaub
SECTION III CLINICAL ANALYSIS
271(68)
13 Mass Spectrometry in Clinical Analysis: Screening for Inborn Errors in Metabolism
273(24)
Donald H. Chace
14 Mass Spectrometry for Steroid Analysis
297(42)
William J. Griffiths
Michael Ogundare
Anna Meljon
Yuqin Wang
SECTION IV FORENSICS
339(50)
15 Forensic Applications of Isotope Ratio Mass Spectrometry
341(32)
Sarah J. Benson
16 Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry
373(16)
Michael E. Sigman
C. Douglas Clark
SECTION V SPACE EXPLORATION
389(28)
17 Mass Spectrometry in Solar System Exploration
391(16)
Paul V. Johnson
Luther W. Beegle
Isik Kanik
18 Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter
407(10)
Jonathan S. Watson
SECTION VI HOMELAND SECURITY
417(112)
19 Methods of Mass Spectrometry in Homeland Security Applications
419(22)
Unige A. Laskay
Erin J. Kaleta
Vicki H. Wysocki
20 Homeland Security
441(36)
Christina L. Crawford
Herbert H. Hill, Jr.
21 Mass Spectrometry in Homeland Security
477(14)
Yasuaki Takada
22 Measurements of Surface Contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer
491(18)
Gary S. Groenewold
Anthony D. Appelhans
Garold L. Gresham
John E. Olson
23 Determination of Actinides: Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios
509(20)
R. Steven Pappas
SECTION VII FOOD ANALYSIS
529(46)
24 Mass Spectrometry in Agriculture, Food, and Flavors: Selected Applications
531(28)
Maciej Stobiecki
Piotr Kachlicki
Henryk Jelen
25 Top-Down Proteomic Identification of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS
559(16)
Clifton K. Fagerquist
Omar Sultan
SECTION VIII ENVIRONMENTAL
575(70)
26 Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry
577(16)
Wolfgang Schwack
27 Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry
593(12)
Chongzheng Na
Terese M. Olson
28 Proton Transfer Reaction Mass Spectrometry (PTR-MS)
605(26)
Yujie Wang
Chengyin Shen
Jianquan Li
Haihe Jiang
Yannan Chu
29 Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices
631(14)
Diana Poli
SECTION IX GEOLOGICAL
645(118)
30 Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions
647(28)
Simon C. George
Herbert Volk
Adriana Dutkiewicz
31 LA-MC-ICP-MS Applied to U-Pb Zircon Geochronology
675(32)
Alain Cocherie
Michele Robert
32 Hydrocarbon Processing
707(18)
Maoqi Feng
Thomas Andrews
Eloy Flores III
33 Hydrocarbon Processing: MALDI-MS of Polydisperse Hydrocarbon Samples
725(24)
Alan A. Herod
34 Renewable Energy: Mass Spectrometry in Biofuel Research
749(14)
Ingvar Eide
Kolbjørn Zahlsen
SECTION X ARCHAEOLOGY
763(122)
35 Mass Spectrometry in Archaeology
765(32)
Robert Hedges
James McCullagh
36 Archaeometric Data from Mass Spectrometric Analysis of Organic Materials: Proteins, Lipids, Terpenoid Resins, Lignocellulosic Polymers, and Dyestuff
797(32)
Maria Perla Colombini
Francesca Modugno
Erika Ribechini
37 Laser Ablation ICP-MS in Archaeology
829(16)
Hector Neff
38 Spatially Resolved MS in the Study of Art and Archaeological Objects
845(14)
Giuseppe Spoto
39 Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples
859(26)
Martin Resano
Esperanza Garcia-Ruiz
Frank Vanhaecke
SECTION XI SURFACE ANALYSIS
885(176)
40 Mass Spectrometry in Semiconductor Research
887(56)
Stefan Flege
Wolfgang Ensinger
41 Analysis of Thin and Thick Films
943(18)
Philippe Le Coustumer
Patrick Chapon
Agnes Tempez
Yuriy Popov
George Thompson
Igor Molchan
Nicolas Trigoulet
Peter Skeldon
Antonino Licciardello
Nunzio Tuccitto
Ivan Delfanti
Katrin Fuhrer
Marc Gonin
James Whitby
Markus Hohl
Christian Tanner
Nerea Bordel Garcia
Lara Lobo Revilla
Jorge Pisonero
Rosario Pereiro
Cristina Gonzalez Gago
Alfredo Sanz Medel
Mihai Ganciu Petcu
Ani Surmeian
Constantin Diplasu
Andreea Groza
Norbert Jakubowski
Roland Dorka
Stela Canulescu
Johann Michler
Philippe Belenguer
Thomas Nelis
Abdellatif Zahri
Philippe Guillot
Laurent Therese
Arnaud Littner
Richard Vaux
Julien Malherbe
Frederic Huneau
Fred Stevie
Hugues Francois-Saint-Cyr
42 SIMS for Organic Film Analysis
961(56)
Taoufiq Mouhib
Arnaud Delcorte
43 Ceramics: Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals
1017(44)
Luisa Ottolini
Emanuela Schingaro
Fernando Scordari
SECTION XII POLYMERS
1061(82)
44 ETV-ICPMS for Analysis of Polymers
1063(16)
Maite Aramendia Marzo
Martin Resano
Frank Vanhaecke
45 Polymers
1079(28)
Maurizio S. Montaudo
Salvatore Battiato
46 Mass Spectroscopy in Polymer Research
1107(28)
Jale Hacaloglu
Talat Yalcin
47 Laser Mass Spectrometry Applied to the Analysis of Polymers
1135(8)
Jerome Bour
David Ruch
SECTION XIII ANALYTICAL TECHNIQUES
1143(140)
48 Measuring Thermodynamic Properties of Metals and Alloys
1145(36)
Evan H. Copland
Nathan S. Jacobson
49 High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules
1181(26)
Gertrud E. Morlock
50 Laser Ionization Mass Spectrometry of Inorganic Ions
1207(22)
Julius Pavlov
Athula B. Attygalle
51 Mass Spectrometry in the SSITKA Studies
1229(28)
L.G. Pinaeva
E.M. Sadovskaya
A.P. Suknev
V.B. Goncharov
B.S. Bal'zhinimaev
52 Proton Transfer Reaction Mass Spectrometry: Applications in the Life Sciences
1257(26)
Elena Crespo
Marco M.L. Steeghs
Simona M. Cristescu
Frans J.M. Harren
Index 1283
Mike S. Lee is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.