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E-raamat: Membrane Potential Imaging in the Nervous System and Heart

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This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling . This is an expanded and fully-updated second edition, reflecting all the recent advances in this field.

Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations, and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs, and genetically encoded voltage sensors.

Membrane Potential Imaging in the Nervous System and Heart, second edition, is ideal for neurologists, electrophysiologists, cardiologists, and those who are interested in the applications and the future of membrane potential imaging.

Part I Principles of Membrane Potential-Imaging
1 Historical Overview and General Methods of Membrane Potential Imaging
3(24)
Oliver Braubach
Lawrence B. Cohen
Yunsook Choi
2 Design and Use of Organic Voltage Sensitive Dyes
27(30)
Leslie M. Loew
Part II Membrane Potential Signals with Single Cell Resolution
3 Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines
57(46)
Marko Popovic
Kaspar Vogt
Knut Holthoff
Arthur Konnerth
Brian M. Salzberg
Amiram Grinvald
Srdjan D. Antic
Marco Canepari
Dejan Zecevic
4 Combining Membrane Potential Imaging with Other Optical Techniques
103(24)
Nadia Jaafari
Kaspar E. Vogt
Peter Saggau
Loew M. Leslie
Dejan Zecevic
Marco Canepari
5 Monitoring Spiking Activity of Many Individual Neurons in Invertebrate Ganglia
127(22)
W.N. Frost
C.J. Brandon
A.M. Bruno
M.D. Humphries
C. Moore-Kochlacs
T.J. Sejnowski
J. Wang
E.S. Hill
Part III Monitoring Activity of Networks and Large Neuronal Populations
6 Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes
149(22)
Kevin L. Briggman
William B. Kristan
Jesus E. Gonzalez
David Kleinfeld
Roger Y. Tsien
7 Monitoring Population Membrane Potential Signals from Neocortex
171(26)
Jianmin Liang
Weifeng Xu
Xinling Geng
Jian-Young Wu
8 Voltage Imaging in the Study of Hippocampal Circuit Function and Plasticity
197(16)
Brandon J. Wright
Meyer B. Jackson
9 Monitoring Population Membrane Potential Signals During Development of the Vertebrate Nervous System
213(30)
Yoko Momose-Sato
Katsushige Sato
Kohtaro Kamino
10 Imaging the Dynamics of Mammalian Neocortical Population Activity In-Vivo
243(30)
Amiram Grinvald
David Omer
Shmuel Naaman
Dahlia Sharon
11 Imaging the Dynamics of Neocortical Population Activity in Behaving and Freely Moving Mammals
273(26)
Amiram Grinvald
Carl C.H. Petersen
Part IV Monitoring Membrane Potential in the Heart
12 Optical Imaging of Cardiac Action Potential
299(14)
Arkady Pertsov
Richard D. Walton
Olivier Bernus
13 Optical Mapping of Ventricular Fibrillation Dynamics
313(30)
Sarah A. Park
Richard A. Gray
14 Imaging of Ventricular Fibrillation and Defibrillation: The Virtual Electrode Hypothesis
343(24)
Bastiaan J. Boukens
Sarah R. Gutbrod
Igor R. Efimov
15 Biophotonic Modelling of Cardiac Optical Imaging
367(38)
Martin J. Bishop
Gernot Plank
16 Towards Depth-Resolved Optical Imaging of Cardiac Electrical Activity
405(22)
Richard D. Walton
Olivier Bernus
Part V New Approaches: Potentials and Limitations
17 Two-Photon Excitation of Fluorescent Voltage-Sensitive Dyes: Monitoring Membrane Potential in the Infrared
427(28)
Jonathan A.N. Fisher
Brian M. Salzberg
18 Random-Access Multiphoton Microscopy for Fast Three-Dimensional Imaging
455(18)
Gaddum Duemani Reddy
Ronald J. Cotton
Andreas S. Tolias
Peter Saggau
19 Second Harmonic Imaging of Membrane Potential
473(20)
Leslie M. Loew
Aaron Lewis
20 Genetically Encoded Protein Sensors of Membrane Potential
493(18)
Douglas Storace
Masoud Sepehri Rad
Zhou Han
Lei Jin
Lawrence B. Cohen
Thom Hughes
Bradley J. Baker
Uhna Sung
Index 511
Marco Canepari (b. Milan 1970) is first class INSERM researcher (CR1) working at the Laboratoire Interdisciplinaire de Physique in Grenoble. He graduated in physics at the University of Genoa and received his PhD in biophysics from the International School for Advanced Studies in Trieste. He worked at the National Institute for Medical Research in London, at Yale University and at the University of Basel. Marco is expert on several optical techniques applied to neurophysiology. Marco and Dejan collaborated for a number of years using voltage-imaging and calcium imaging approaches to study mechanisms underlying synaptic plasticity.

Olivier Bernus (b. Tournai 1976) is Professor and Scientific Director at the Electrophysiology and Heart Modeling Institute LIRYC at the University of Bordeaux, France. He graduated in Mathematical Physics at the University of Ghent, Belgium and obtained his PhD in Physics from the same university. He subsequently worked as a postdoctoral fellow at SUNY Upstate Medical University, USA, and as a tenure track research fellow at the University of Leeds, UK. Olivier is an expert in cardiac optical imaging and is currently working on the development of novel techniques for three-dimensional depth-resolved optical imaging of cardiac electrical activity.

Dejan Zecevic (b. Belgrade 1948) is Senior Research Scientist at the Department of Cellular and Molecular Physiology, Yale University School of Medicine. He received the PhD in Biophysics from The University of Belgrade, Serbia and was trained in the laboratory of Dr Lawrence Cohen who initiated the field of voltage-sensitive dye recording. Dejan is the pioneer of intracellular voltage-sensitive dye imaging technique, a unique and a cutting edge technology for monitoring the membrane potential signaling in axons, dendrites and dendritic spines of individual nerve cells.