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Music of Life: Biology beyond the Genome [Kõva köide]

(Professor of Cardiovascular physiology at the University of Oxford)
  • Formaat: Hardback, 168 pages, kõrgus x laius x paksus: 204x137x20 mm, kaal: 280 g, 7 figures
  • Ilmumisaeg: 08-Jun-2006
  • Kirjastus: Oxford University Press
  • ISBN-10: 0199295735
  • ISBN-13: 9780199295739
Teised raamatud teemal:
  • Formaat: Hardback, 168 pages, kõrgus x laius x paksus: 204x137x20 mm, kaal: 280 g, 7 figures
  • Ilmumisaeg: 08-Jun-2006
  • Kirjastus: Oxford University Press
  • ISBN-10: 0199295735
  • ISBN-13: 9780199295739
Teised raamatud teemal:
The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyond the "selfish gene" to consider life on a much wider variety of levels.
Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noble sets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in an intricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of the nature of life.
Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

Arvustused

An excellent informal introduction to the concepts and issues that form the bedrock of systems biology... His conversational style gives readers the feeling they are with him sharing in an active process of discovery. * Eric Werner, Science * highly evocative essay * Steven Poole, Guardian *

Introduction ix
The CD of Life: the Genome
1(22)
Introducing the Silmans
1(2)
DNA-mania
3(3)
Problems with genetic determinism
6(5)
Origin of the appeal of genetic determinism
11(4)
Life is not a protein soup
15(2)
Mapping the alternative metaphors
17(6)
The Organ of 30,000 Pipes
23(10)
The Chinese Emperor and the poor farmer
23(4)
The genome and combinatorial explosion
27(4)
An organ of 30 000 pipes
31(2)
The Score: is it Written Down?
33(9)
Is the genome the `book of life'?
33(2)
The French bistro omelette
35(2)
The ambiguity of language
37(2)
The Silmans return
39(3)
The Conductor: Downward Causation
42(13)
How is the genome played?
42(1)
Is the genome a program?
43(3)
Control of gene expression
46(2)
Downward causation takes many forms
48(1)
Other forms of downward causation
49(2)
Where is the program of life?
51(4)
The Rhythm Section: the Heartbeat and other Rhythms
55(19)
Beginnings of biological computation
55(1)
Reconstructing heart rhythm: the first attempt
56(5)
The integrative level of heart rhythm
61(4)
Systems biology is not `vitalism' in disguise
65(1)
Nor is it reductionism in disguise
65(2)
Other natural rhythms
67(7)
The Orchestra: Organs and Systems of the Body
74(14)
Novartis Foundation debates
74(1)
Problems with bottom-up
75(3)
Problems with top-down
78(1)
Middle-out!
79(3)
The organs of the body
82(1)
The virtual heart
83(5)
Modes and Keys: Cellular Harmony
88(13)
The Silmans find some tropical islands
88(4)
The Silmans' mistake
92(1)
Genetic basis of cell differentiation
93(3)
Modes and keys
96(1)
Multicellular harmony
97(2)
A historical note on `Lamarckism'
99(2)
The Composer: Evolution
101(12)
The Chinese writing system
101(2)
Modularity in genes
103(1)
Gene-protein networks
104(2)
Fail-safe redundancy
106(3)
Faustian pacts with the devil
109(2)
The logic of life
111(1)
The grand composer
112(1)
The Opera Theatre: the Brain
113(22)
How do we see the world?
114(5)
At Aziz' restaurant
119(3)
Action and will: a physiologist and a philosopher experiment
122(3)
Explanatory shift between levels
125(3)
The self is not a neural object
128(3)
The deep-frozen brain
131(1)
The resurrected self?
132(3)
Curtain Call: the Artist Disappears
135(9)
Jupitereans
135(2)
Role of culture in our view of the self and the brain
137(4)
The self as metaphor
141(2)
The artist disappears
143(1)
Bibliography 144(3)
Index 147
Denis Noble, CBE, FRS, is Professor of Cardiovascular Physiology at the University of Oxford and is widely regarded as one of the popular proponents (and a very early founder of) of systems biology. He was Chairman of the IUPS World Congress in 1993, and Secretary-General of IUPS from 1993-2001. He played a major role in launching the Physiome Project, one of the international components of the systems biology approach, and Science included him amongst its review authors for its issue devoted to the subject in 2002.

His previous publications include the seminal set of essays The Logic of Life (Boyd and Noble, OUP 1993), and he frequently appears in newspapers, and on TV and radio.