Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.
This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.
Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.
- Describes various microfluidic systems and fabrication methods
- Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more
- Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips
1. Techniques and Materials for the Fabrication of Microfluidic Chips
2. Critical Factors Affecting Cells Behaviour in Microfluidic Chips
3. Cell-Based Assays on Microfluidic Chips
4. Cell Culture Techniques in Microfluidic Chips
5. Skin-On-A-Chip
6. Blood Vessels-On-A-Chip
7. Heart-On-A-Chip
8. Liver-On-A-Chip
9. Lung-On-A-Chip
10. Gut-On-A-Chip
11. Kidney-On-A-Chip
12. Immune Organs-On-Chip
13. Nervous Systems on a Chip
14. Eye-On-A-Chip
15. Endocrine Organs-On-A-Chip
16. Musculoskeletal Tissue-On-a-Chip
17. Tumour-On-A-Chip
18. Multi Organs-On-A-Chip and Personalized Medicine
19. Computational modelling of organ-on-a-chip devices
20. Commercialized Microfabricated Cell Chips
21. Organs-On-A-Chip: Future perspectives
Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafaris research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.
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