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E-raamat: Signaling Pathways in Liver Diseases 3e 3rd Edition [Wiley Online]

Edited by (University Clinic Visceral Surgery and Medicine, Bern, Switzerland), Edited by (Department of Visceral and Transplant Surgery, University Hospital Zurich)
  • Formaat: 520 pages
  • Ilmumisaeg: 30-Oct-2015
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 1118663381
  • ISBN-13: 9781118663387
Teised raamatud teemal:
  • Wiley Online
  • Hind: 296,04 €*
  • * hind, mis tagab piiramatu üheaegsete kasutajate arvuga ligipääsu piiramatuks ajaks
  • Formaat: 520 pages
  • Ilmumisaeg: 30-Oct-2015
  • Kirjastus: Wiley-Blackwell
  • ISBN-10: 1118663381
  • ISBN-13: 9781118663387
Teised raamatud teemal:
Signaling Pathways in

Liver Diseases

THIRD EDITION

Signaling Pathways in Liver Diseases, Third Edition again provides hepatrologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided a clear yet comprehensive review of their chosen topic. Chapters contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.

Signaling Pathways in Liver Diseases, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Signalling Pathways in Liver Diseases 3E again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signalling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohatitis, cirrhosis and liver tumours, which has led in changes to the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

  • Autophagy
  • Notch Pathway
  • PI3K/PTEN Signaling in Liver Diseases
  • Sirtuins
  • Hepcidin and Iron
  • Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
  • Oxidative Stress and Signaling in the Liver

Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom will provide write a clear yet comprehensive review of their chosen topic. Chapters will contain clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.


Signalling Pathways in Liver Diseases 3E
is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.
List of Contributors
vii
1 Hepatocytes
1(14)
Jean-Francois Dufour
Joachim C. Mertens
2 Signaling pathways in biliary epithelial cells
15(19)
M. Fatima Leite
Mateus T. Guerra
Viviane A. Andrade
Michael H. Nathanson
3 Stellate cells
34(27)
Alessandra Caligiuri
Fabio Marra
4 Kupffer cells
61(12)
Amirali Kiyani
Ekihiro Seki
5 Hepatic sinusoidal endothelial cells
73(12)
Moira B. Hilscher
Robert C. Huebert
Vijay H. Shah
6 Extracellular matrix
85(12)
Scott L. Friedman
7 Platelets: a new cell type in liver physiology
97(13)
Mickael Lesurtel
Pierre-Alain Clavien
8 Immune cell communication in liver disease and liver regeneration
110(20)
Ricky H. Boghal
B.F. Stephenson
Simon C. Afford
9 Extracellular vesicle RNA in liver disease
130(9)
Tushar Patel
Hiroaki Haga
10 Endoplasmic reticulum stress in nonalcoholic fatty liver disease
139(12)
Fabienne Foufelle
Pascal Ferre
11 Autophagy
151(15)
Hao Zhang
Bilon Khambu
Xiao-Ming Yin
12 CXC chemokine receptor signaling in liver repair and regeneration
166(8)
Gregory C. Wilson
Christopher M. Freeman
Hiroyuki Nojima
Alex B. Lentsch
13 Metabolic regulation of liver regeneration
174(12)
Jiansheng Huang
David A. Rudnick
14 TNF signaling
186(17)
Amrit Mann
Mark J. Czaja
Jorn M. Schattenberg
15 Fas/FasL
203(11)
Maria Eugenia Guicciardi
Gregory J. Gores
16 Interferon signaling
214(12)
Markus H. Heim
17 Endocannabinoid signaling in liver pathologies
226(14)
Bostjan Humar
Nasser Semmo
18 The WNT/β-catenin pathway
240(22)
Satdarshan P. Singh Monga
19 Hedgehog signaling in the liver
262(13)
Mariana V. Machado
Anna Mae Diehl
20 Notch pathway
275(12)
Sonja Rothweiler
David Semela
21 P13K/PTEN signaling in liver diseases
287(27)
Alfredo Fort
Nicolas Calo
Dorothea Portius
Lucie Bourgoin
Marion Peyrou
Michelangelo Foti
22 mTOR signaling in liver disease
314(12)
Marion Cornu
Gregoire de Caudron de Coquereaumont
Michael N. Hall
23 LKB1/AMPK pathway in the control of hepatic energy metabolism
326(13)
Benoit Viollet
Marc Foretz
24 NF-κB
339(9)
Ekihiro Seki
David A. Brenner
25 c-Jun NH2-terminal kinases in liver diseases
348(16)
Johannes Kluwe
Robert F. Schwabe
26 p53
364(10)
Aundrietta D. Duncan
Wen-Wei Tsai
Michelle Craig Barton
27 Sirtuins
374(11)
Frank K. Huynh
Eoin McDonnell
Kristin A. Anderson
Matthew D. Hirschey
28 Bile acids and their receptors
385(15)
Thierry Claudel
Michael Trauner
29 Hepcidin and iron
400(11)
Chiara Vecchi
Antonello Pietrangelo
30 Gut microbiome and liver diseases
411(10)
Herbert Tilg
Alexander R. Moschen
31 Epigenetic regulation of hepatic stellate cells and liver fibrosis
421(14)
Jelena Mann
Derek A. Mann
32 Signaling in hepatocellular careinoma
435(13)
Adam Pennyuiek
Augusto Villanueva
33 Interplay between hepatitis B virus and innate immune signaling pathways
448(11)
Barbara Testoni
David Durantel
Fabien Zoulim
34 Signaling of hepatitis C virus
459(10)
Joachim Lupberger
Nicolaas Van Renne
Thomas F. Baumert
35 Oxidative stress and signaling in the liver
469(10)
Mitchell R. McGill
Yuchao Xie
Hartmut Jaeschke
Answers to MCQs 479(4)
Index 483
Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland. Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL).  He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology

Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland. Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland.  His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.