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State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3.: Defining the Next Generation of Analytical and Biophysical Techniques [Kõva köide]

Edited by (Director, Novavax, Inc.), Edited by (Research Chemist, NIST Biomolecular Measurement Division, National Institute of Standards and Technology), Edited by (Associate Director, Janssen Research and Development, LLC)
  • Formaat: Hardback, 464 pages, kõrgus x laius x paksus: 232x162x35 mm, kaal: 954 g, 128
  • Sari: ACS Symposium Series
  • Ilmumisaeg: 01-Sep-2016
  • Kirjastus: Oxford University Press Inc
  • ISBN-10: 0841230315
  • ISBN-13: 9780841230316
Teised raamatud teemal:
State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 3.: Defining the Next Generation of Analytical and Biophysical TechniquesSuurem pilt
  • Formaat: Hardback, 464 pages, kõrgus x laius x paksus: 232x162x35 mm, kaal: 954 g, 128
  • Sari: ACS Symposium Series
  • Ilmumisaeg: 01-Sep-2016
  • Kirjastus: Oxford University Press Inc
  • ISBN-10: 0841230315
  • ISBN-13: 9780841230316
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780841230316.html
Märksõnad:
This volume describes novel and emerging analytical technologies for analysis of proteins with the emphasis on technologies aimed to address characterization "knowledge gaps" and/or improve our ability to measure specified attributes with improved selectivity, sensitivity, resolution, and throughput.

Higher order structure of proteins is a recognized important attribute of mAbs, with potential implications on stability, safety, and biological function of these large molecules. This book, the last in a series of three volumes, touches on topics ranging from X-ray crystallography, NMR, hydrogen-deuterium exchange mass spectrometry, covalent labeling techniques, and ion mobility mass spectrometry.
Preface ix
1 Trends and Drivers for the Development of Next-Generation Biotherapeutic Characterization Tools
1(16)
Oleg V. Borisov
John E. Schiel
Darryl Davis
2 Emerging Technologies To Assess the Higher Order Structure of Monoclonal Antibodies
17(28)
J. P. Marino
R. G. Brinson
J. W. Hudgens
J. E. Ladner
D. T. Gallagher
E. S. Gallagher
L. W. Arbogast
R. Y.-C. Huang
3 Covalent Labeling Techniques for Characterizing Higher Order Structure of Monoclonal Antibodies
45(30)
Parminder Kaur
Janna Kiselar
Wuxian Shi
Sichun Yang
Mark R. Chance
4 Ion Mobility and Mass Spectrometry Measurements of the Humanized IgGk NIST Monoclonal Antibody
75(38)
Iain D. G. Campuzano
Carlos Larriba
Dhanashri Bagal
Paul D. Schnier
5 Characterization of Monoclonal Antibody Aggregates and Emerging Technologies
113(46)
Richard L. Remmele, Jr.
Jared S. Bee
Jonathan J. Phillips
Wenjun David Mo
Daniel R. Higazi
Jifeng Zhang
Vivian Lindo
Alistair D. Kippen
6 Simultaneous Multiple Sample Light Scattering (SMSLS) for Continuous Monitoring of Protein Aggregation
159(30)
Michael F. Drenski
Mark L. Brader
Wayne F. Reed
7 Informatics for Mass Spectrometry-Based Protein Characterization
189(38)
Wenzhou Li
Hua Xu
Oleg Borisov
8 Adventitious Agent Testing of Biologicals: Changing to a New Frontier of Technology, Cell-Based to Nucleic Acid-Based Detection
227(18)
Ivar Kljavin
Kevin McCarthy
Dieter Schmalzing
9 Monoclonal Antibody Analysis Using Microfluidic Technologies
245(44)
G. O. Staples
O. G. Potter
H. Yin
10 Intact Antibody Characterization Using Orbitrap Mass Spectrometry
289(28)
Zhiqi Hao
Terry Zhang
Yue Xuan
Hongxia Wang
Jie Qian
Shanhua Lin
Jenny Chen
David M. Horn
Dayana Argoti
Alain Beck
Sarah Cianferani
Patrick Bennett
Ken Miller
Alexander Makarov
11 Rapid Middle-Down Sequence Determination of Antibodies by MALDI In-Source Decay MS
317(18)
Sergei Dikler
Amanda L. Bulman
12 Automated, Online Sample Preparation for LC-MS Analyses: Affinity Capture, Digestion, and Clean-Up
335(22)
David R. Colquhoun
Brian J. Feild
13 Improved Identification and Quantification of Host Cell Proteins (HCPs) in Biotherapeutics Using Liquid Chromatography-Mass Spectrometry
357(38)
Weibin Chen
Catalin E. Doneanu
Matthew Lauber
Stephan Koza
Kesh Prakash
Martha Stapels
Kenneth J. Fountain
14 Towards a Comprehensive Bioinformatic Analysis of the NIST Reference mAb
395(20)
Yong J. Kil
Marshall Bern
Kevin Crowell
Doron Kletter
Nicholas Bern
Wilfred Tang
Eric Carlson
Christopher Becker
15 A Global Partnership Advancing Biopharmaceutical Development: Summary and Future Perspectives
415(32)
John E. Schiel
Michael J. Tarlov
Karen W. Phinney
Oleg V. Borisov
Darryl L. Davis
Appendix
433(10)
Editors' Biographies
443(4)
Indexes
Author Index 447(2)
Subject Index 449
Dr. John E. Schiel received his B.S. (2004) and Ph.D.(2009) in Chemistry from the University of Nebraska-Lincoln, and is currently a research chemist in the NIST Biomolecular Measurement Division.

Dr. Darryl L. Davis holds a doctorate in Medicinal Chemistry from the Philadelphia College of Pharmacy and Science. Currently he leads an analytical group within the discovery organization at Janssen R&D.

Dr. Oleg V. Borisov earned a B.S. degree (with honors) in Chemistry at Moscow State University (1992), and received his Ph.D. in Chemistry from Wayne State University (1997), after which he completed his post-doctoral studies at Lawrence Berkeley National Laboratories (2000) and Pacific Northwest National Laboratories (2001). He is currently a Director at Novavax, Inc., developing methods and strategies for analysis and characterization of recombinant vaccines, based on nano- and virus-like particle technologies.