This revised and updated new edition of a best-selling text remains a fast and convenient overview of the clinical trials in gynecologic cancer treatment, outlining the evidence base of treatment decisions in uterine, ovarian, cervical, and vulvar cancers, and gestational trophoblastic neoplasia. Residents and fellows will find this book an indispensable reference, while practitioners will welcome it as a clarification of the evidence base for treatment options.
*Gives a convenient summary of trials in gynecologic oncology *Supplies an invaluable revision primer for those undertaking certification *Provides a uniquely up-to-date resource
| Preface to the Second Edition |
|
ix | |
|
|
|
1 | (42) |
|
1.1 Endometrial Carcinoma |
|
|
1 | (26) |
|
1.1.1 Studies Addressing Surgical Treatment |
|
|
1 | (2) |
|
1.1.1.1 Lymph Node Assessment |
|
|
3 | (5) |
|
1.1.2 Studies Addressing Adjuvant Therapy |
|
|
8 | (1) |
|
|
|
8 | (3) |
|
|
|
11 | (4) |
|
|
|
15 | (3) |
|
1.1.3 Studies Addressing Treatment of Recurrent Endometrial Carcinoma |
|
|
18 | (1) |
|
|
|
18 | (2) |
|
|
|
20 | (1) |
|
|
|
21 | (2) |
|
|
|
23 | (4) |
|
1.2 Uterine Carcinosarcoma |
|
|
27 | (4) |
|
1.2.1 Studies Addressing Prognosticators |
|
|
27 | (1) |
|
1.2.2 Studies Addressing Adjuvant Treatment |
|
|
27 | (2) |
|
1.2.3 Studies Addressing Treatment of Advanced/Recurrent Uterine Carcinosarcoma |
|
|
29 | (2) |
|
1.3 Uterine Leiomyosarcoma |
|
|
31 | (12) |
|
1.3.1 Studies Addressing Adjuvant Treatment of Early-Stage Uterine Leiomyosarcoma |
|
|
31 | (2) |
|
1.3.2 Studies Addressing Treatment of Advanced Uterine Leiomyosarcoma |
|
|
33 | (4) |
|
|
|
37 | (6) |
|
|
|
43 | (66) |
|
2.1 Epithelial Ovarian Cancer |
|
|
43 | (49) |
|
2.1.1 Studies Addressing Upfront Surgery |
|
|
43 | (1) |
|
2.1.2 Studies Addressing Adjuvant Therapy |
|
|
44 | (10) |
|
2.1.3 Studies Addressing Intraperitoneal Chemotherapy |
|
|
54 | (4) |
|
2.1.4 Studies Addressing First-Line Maintenance Treatment |
|
|
58 | (5) |
|
2.1.5 Studies Addressing Neoadjuvant Therapy |
|
|
63 | (3) |
|
2.1.6 Studies Addressing Prediction of Debulking |
|
|
66 | (2) |
|
2.1.7 Studies Addressing Time Point of Treatment for Recurrence |
|
|
68 | (1) |
|
2.1.8 Studies Addressing Treatment of Recurrent Ovarian Cancer, Platinum Sensitive |
|
|
69 | (1) |
|
2.1.8.1 Chemotherapy and Targeted Therapy |
|
|
69 | (13) |
|
2.1.8.2 Secondary Debulking Surgery |
|
|
82 | (3) |
|
2.1.9 Studies Addressing Treatment of Recurrent Ovarian Cancer, Platinum Resistant |
|
|
85 | (1) |
|
2.1.9.1 Chemotherapy and Targeted Therapy |
|
|
85 | (3) |
|
|
|
88 | (4) |
|
2.2 Low-Grade Serous Ovarian Cancer |
|
|
92 | (2) |
|
2.3 Mucinous Epithelial Ovarian Cancer |
|
|
94 | (2) |
|
2.4 Small-Cell Carcinoma of the Ovary |
|
|
96 | (1) |
|
2.5 Ovarian Germ Cell Tumors |
|
|
96 | (1) |
|
2.6 Ovarian Sex Cord-Stromal Tumors |
|
|
97 | (12) |
|
|
|
98 | (11) |
|
|
|
109 | (28) |
|
3.1 Studies Addressing Surgical Treatment |
|
|
109 | (4) |
|
3.2 Studies Addressing Adjuvant Therapy |
|
|
113 | (3) |
|
3.3 Studies Addressing Primary Chemoradiation Therapy |
|
|
116 | (8) |
|
3.4 Studies Addressing Treatment of Recurrent or Metastatic Cervical Cancer |
|
|
124 | (13) |
|
3.4.1 Chemotherapy and Targeted Therapy |
|
|
124 | (5) |
|
|
|
129 | (3) |
|
|
|
132 | (5) |
|
|
|
137 | (10) |
|
4.1 Studies Addressing Surgical Treatment |
|
|
137 | (6) |
|
|
|
140 | (3) |
|
4.2 Studies Addressing Advanced Vulvar Cancer |
|
|
143 | (4) |
|
|
|
143 | (2) |
|
|
|
145 | (1) |
|
|
|
145 | (2) |
|
5 Gestational Trophoblastic Neoplasia |
|
|
147 | (8) |
|
5.1 Studies Addressing Surgical Treatment |
|
|
147 | (1) |
|
5.2 Studies Addressing Chemotherapy in Low-Risk Gestational Trophoblastic Neoplasia |
|
|
148 | (2) |
|
5.3 Studies Addressing (Chemo)Therapy in High-Risk Gestational Trophoblastic Neoplasia |
|
|
150 | (5) |
|
|
|
153 | (2) |
| Glossary |
|
155 | (2) |
| Index |
|
157 | |
Malte Renz, MD, PhD: Division of Gynecologic Oncology, Stanford University School of Medicine, Stanford, California, USA
Elisabeth J. Diver, MD: Division of Gynecologic Oncology, Stanford University School of Medicine, Stanford, California, USA
Whitfield B. Growdon, MD: Division of Gynecologic Oncology, NYU Grossman School of Medicine, New York, New York, USA
Oliver Dorigo, MD, PhD: Division of Gynecologic Oncology, Stanford University School of Medicine, Standford, California, USA