Therapeutic plasma exchange has become an essential tool in modern clinical practice, offering effective treatment for an expanding range of diseases. This book provides a clear and comprehensive guide to the fundamentals of plasma exchange, alongside advanced techniques such as immunoadsorption and LDL apheresis.
Recognizing the critical role of immunosuppression in plasma exchange, the text explores the integration of established and novel immunosuppressive therapies. It outlines current indications across multiple specialtiesincluding nephrology, neurology, hematology, rheumatology, and intensive careand evaluates the latest evidence on clinical outcomes.
Readers will find detailed discussion of international guidelines from leading organizations such as ASFA, KDIGO, and the American College of Rheumatology. The book also addresses emerging applications in oncology and highlights future directions for research and practice.
Designed for nephrologists, rheumatologists, neurologists, hematologists, and intensive care professionals, this resource combines authoritative guidance with a consistent structure for ease of use. It is an indispensable reference for clinicians seeking to enhance their expertise in plasma exchange and stay aligned with the most recent standards in the field.
Introduction. History of Plasma Exchange. Definition of terms.-
Principles of Therapeutic Plasma Exchange.- Indications for PEX: Nephrology.-
Indications for PEX: Hematology.- Indications for PEX: Rheumatology.-
Indications for PEX: Neurology.- Indications for PEX: Endocrinology and
Metabolic Disease.- Indications for PEX: Cardiology and Pulmonology.- Plasma
exchange in Clinical Practice: Gastroenterology.- Plasma exchange in Clinical
Practice: Oncology and Sepsis.- Drug removal in PEX.
Dr Jean J. Filipov is based at the Department of Nephrology and Transplantation, University Hospital Alexandrovska, Sofia, Bulgaria. He obtained his specialist qualifications in Internal Medicine (2010) and Nephrology (2015). From December 2003 to November 2020, and again from October 2021 to the present, he has worked at the Department of Nephrology and Transplantation at University Hospital Alexandrovska.
Dr Filipov served as Head of the Dialysis Unit (December 2021 January 2023) and was an Assistant Professor at the Medical University Sofia (2005 2020). Between December 2020 and October 2021, he was part of the renal and transplantation team at University Hospital Lozenetz, Sofia. In 2015, he earned his PhD on Vitamin D and kidney transplantation. Additionally, Dr Filipov worked as a Specialist Registrar at the John Walls Renal Unit, Leicester, UK (November 2011 April 2012).
Since 2013, Dr Filipov has been actively involved in the plasma exchange program at the Department of Nephrology and Transplantation and contributed to the development of the Bulgarian Guideline for Plasma Exchange in 2016. His professional interests also include mineral bone disease in chronic kidney disease, onconephrology, and kidney transplantation.
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