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xiii | |
| Introduction |
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xvii | |
| Author Biographies |
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xix | |
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1 | (46) |
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1 From Multiwave Imaging to Elasticity Imaging |
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3 | (20) |
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3 | (1) |
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1.2 Regimes of Spatial Resolution |
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3 | (1) |
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1.3 The Multiwave Approach |
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4 | (1) |
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1.4 Wave to Wave Generation |
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5 | (2) |
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7 | (1) |
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1.6 Wave to Wave Imaging: Mapping Elasticity |
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8 | (6) |
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1.7 Super-resolution in Supersonic Shear Wave Imaging |
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14 | (2) |
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1.8 Clinical Applications |
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16 | (3) |
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19 | (4) |
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21 | (2) |
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2 Imaging via Speckle Interferometry and Nonlinear Methods |
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23 | (24) |
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23 | (1) |
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2.2 Part I: Speckle Interferometry |
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24 | (10) |
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24 | (1) |
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25 | (4) |
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2.2.3 Knox-Thompson Method |
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29 | (3) |
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2.2.4 Importance of Phase Difference Calculation |
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32 | (1) |
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2.2.5 Labeyrie and Knox-Thompson in Two Dimensions |
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33 | (1) |
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2.2.6 Other Improvements to Speckle Interferometry |
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34 | (1) |
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2.3 Part II: Nonlinear Imaging |
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34 | (10) |
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34 | (2) |
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2.3.2 Deviation (Difference Squared), or Absolute Difference |
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36 | (1) |
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2.3.3 Fourier Transform-Based Methodology |
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36 | (2) |
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2.3.4 Fourier Methodology: How to Create an Image |
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38 | (1) |
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2.3.5 Fourier Transform: Problems with Using |
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39 | (1) |
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2.3.6 Hilbert Transform-Based Methodology |
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39 | (3) |
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2.3.7 Hilbert Methodology: How to Create an Image, and 3D Image |
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42 | (2) |
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44 | (3) |
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Selected References (By Subject) |
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45 | (1) |
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45 | (1) |
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Speckle: More Advanced Methods |
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45 | (1) |
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45 | (2) |
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Part Two Novel Developments in Advanced Imaging Techniques and Methods |
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47 | (106) |
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3 Fundamentals and Applications of a Quantitative Ultrasonic Microscope for Soft Biological Tissues |
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49 | (22) |
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3.1 General Introduction: Basic Idea of an Ultrasonic Microscope for Biological Tissues |
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49 | (1) |
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50 | (10) |
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50 | (1) |
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3.2.2 Specimen to be Observed |
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50 | (1) |
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3.2.3 Experimental Setup and Acquired Signal |
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51 | (1) |
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3.2.4 Calculation of Sound Speed |
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52 | (1) |
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3.2.4.1 Frequency Domain Analysis |
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52 | (2) |
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3.2.4.2 Time-Frequency Domain Analysis |
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54 | (2) |
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3.2.5 Two-Dimensional Sound Speed Profiles |
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56 | (2) |
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3.2.6 Attempts at Better Spatial Resolution |
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58 | (2) |
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3.3 Acoustic Impedance Profile |
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60 | (10) |
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60 | (1) |
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61 | (1) |
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3.3.3 Specimen to be Observed |
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62 | (1) |
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63 | (1) |
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3.3.5 Calibration for Characteristic Acoustic Impedance |
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63 | (2) |
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3.3.6 Observation of Cerebellar Cortex of a Rat |
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65 | (2) |
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3.3.7 Cell Size Observation |
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67 | (2) |
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3.3.8 Commercialized Equipment |
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69 | (1) |
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70 | (1) |
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70 | (1) |
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4 Portable Ultrasonic Imaging Devices |
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71 | (22) |
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91 | (2) |
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5 High-Frequency Ultrasonic Systems for High-Resolution Ranging and Imaging |
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93 | (32) |
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93 | (1) |
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5.2 High-Frequency Ultrasonic System Components |
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94 | (10) |
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5.2.1 Ultrasound Echo Systems |
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94 | (1) |
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5.2.2 Transmitter and Receiver Components for High-Frequency Ultrasonic Echo Systems |
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95 | (2) |
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5.2.3 Spectral and Range Resolution Properties |
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97 | (2) |
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5.2.4 Measurement and Optimization of the Pulse Transfer Properties |
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99 | (2) |
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5.2.5 Range Resolution Optimization: Inverse Echo Signal Filtering |
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101 | (1) |
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5.2.6 Measurement of Acoustic Scattering Parameters in Plane Wave Propagation |
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102 | (2) |
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5.3 Engineering Concepts for High-Frequency Ultrasonic Imaging |
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104 | (11) |
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5.3.1 Single-Element Transducer B-Scan Techniques |
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104 | (1) |
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5.3.2 Lateral Resolution Optimization |
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105 | (1) |
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5.3.2.1 B/D-Scan Technique |
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106 | (1) |
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5.3.2.2 Synthetic Aperture Focusing Techniques (SAFT) |
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106 | (4) |
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5.3.3 Limited Angle Spatial Compounding (LASC) |
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110 | (2) |
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5.3.4 Multidirectional Tissue Characterization |
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112 | (3) |
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5.4 High-Frequency Ultrasound Imaging in Biomedical Applications |
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115 | (3) |
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115 | (2) |
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5.4.2 Imaging of Small Animals |
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117 | (1) |
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118 | (7) |
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119 | (6) |
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6 Quantitative Acoustic Microscopy Based on the Array Approach |
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125 | (28) |
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125 | (1) |
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6.2 Measurement of Velocity and Attenuation of Leaky Waves |
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126 | (15) |
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6.3 Measurement of Bulk Wave Velocities and Thickness of Specimen |
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141 | (9) |
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150 | (3) |
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150 | (3) |
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Part Three Advanced Biomedical Applications |
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153 | (78) |
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7 Study of the Contrast Mechanism in an Acoustic Image for Thickly Sectioned Melanoma Skin Tissues with Acoustic Microscopy |
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155 | (32) |
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155 | (3) |
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155 | (1) |
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7.1.2 How Is Melanoma Diagnosed? |
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156 | (1) |
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7.1.3 Present Problems for Biopsy |
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157 | (1) |
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7.1.4 Objective of Present Study |
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157 | (1) |
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7.2 Physical and Mathematical Modeling for Five Layer Wave Propagation in an Acoustic Microscope |
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158 | (4) |
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162 | (1) |
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7.4 Digital Imaging-Optical and Ultrasonic |
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163 | (11) |
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163 | (1) |
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7.4.2 Acoustic Imaging Principle (Pulse-Wave Mode) |
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164 | (4) |
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168 | (1) |
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169 | (2) |
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171 | (3) |
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7.5 High Frequency Acoustic Microscopy |
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174 | (7) |
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7.5.1 Normal Control Skin Tissue |
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174 | (1) |
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7.5.2 Abnormal Skin Tissue |
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175 | (1) |
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175 | (2) |
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7.5.4 Computer Simulation |
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177 | (1) |
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7.5.4.1 Experimental V(z) Curve |
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177 | (1) |
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7.5.4.2 Theoretical V(z) Curve (Simulation of V(z) Curve) |
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178 | (3) |
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181 | (6) |
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183 | (1) |
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183 | (4) |
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8 New Concept of Pathology-Mechanical Properties Provided by Acoustic Microscopy |
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187 | (20) |
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187 | (1) |
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8.2 Principle of Acoustic Microscopy |
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188 | (1) |
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8.3 Application to Cellular Imaging |
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189 | (2) |
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8.4 Application to Hard Tissues |
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191 | (2) |
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8.5 Application to Soft Tissues |
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193 | (7) |
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193 | (2) |
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8.5.2 Myocardial Infarction |
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195 | (2) |
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197 | (1) |
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197 | (3) |
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8.6 Ultrasound Speed Microscopy (USM) |
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200 | (2) |
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202 | (1) |
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202 | (5) |
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204 | (3) |
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9 Quantitative Scanning Acoustic Microscopy of Bone |
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207 | (24) |
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207 | (6) |
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9.1.1 Hierarchical Structure of Bone and Properties |
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207 | (2) |
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9.1.2 Relevance of Multiscale Elastic Properties |
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209 | (1) |
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9.1.3 History of Measurement Principles |
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210 | (3) |
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9.2 Quantitative SAM-Based Impedance of Bone |
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213 | (6) |
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213 | (3) |
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9.2.2 Time-Resolved Measurements |
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216 | (1) |
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9.2.3 Measurements with Time-Gated Amplitude Detection |
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217 | (1) |
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218 | (1) |
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9.3 Tissue Mineralization, Acoustic Impedance, and Stiffness |
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219 | (3) |
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9.4 Elastic Anisotropy at the Nanoscale (Lamellar) Level |
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222 | (1) |
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9.5 Elastic Anisotropy at the Microscale (Tissue) Level |
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223 | (2) |
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9.6 Applications in Musculoskeletal Research |
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225 | (1) |
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226 | (5) |
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228 | (3) |
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Part Four Advanced Materials Applications |
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231 | (140) |
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10 Array Imaging and Defect Characterization Using Post-processing Approaches |
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233 | (44) |
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233 | (4) |
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237 | (8) |
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237 | (1) |
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10.2.2 Ray-Based Description of Ultrasonic Array Data |
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238 | (1) |
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10.2.2.1 Determining the Ray-Paths |
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238 | (2) |
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10.2.2.2 Predicting the Signal Associated with a Ray-Path |
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240 | (1) |
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240 | (2) |
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10.2.3 Mathematical Model of Ultrasonic Array Data |
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242 | (3) |
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10.3 Imaging with 1D Arrays |
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245 | (10) |
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10.3.1 Classical Beam-Forming Imaging Methods in Post-processing |
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245 | (1) |
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10.3.2 Total Focusing Method |
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246 | (1) |
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247 | (2) |
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10.3.4 Back-Propagation Method |
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249 | (1) |
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10.3.5 Theoretical Comparison of Imaging Methods |
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250 | (1) |
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10.3.6 Computational Burden |
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251 | (1) |
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10.3.7 Focusing Performance |
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252 | (1) |
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10.3.8 Experimental Example |
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253 | (2) |
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10.4 Imaging with 2D Arrays |
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255 | (5) |
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10.4.1 Optimization of 2D Array Layout |
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255 | (1) |
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10.4.1.1 Optimization Criterion |
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255 | (1) |
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10.4.1.2 Regular Sampling |
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256 | (1) |
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10.4.1.3 Non-uniform Sampling |
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257 | (1) |
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10.4.2 Experimental Comparison of 2D Array Layouts |
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258 | (1) |
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10.4.2.1 Spherical Inclusion |
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259 | (1) |
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10.4.2.2 Aluminum Block with Flat Bottom Holes |
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260 | (1) |
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10.4.2.3 Surface-Breaking Fatigue Crack |
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260 | (1) |
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10.5 Scattering Matrices and Their Experimental Extraction |
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260 | (7) |
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10.5.1 Feature Extraction from Array Data |
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262 | (1) |
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262 | (1) |
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263 | (3) |
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10.5.1.3 Extraction of Scattering Matrix |
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266 | (1) |
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10.6 Defect Characterization and Sizing |
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267 | (5) |
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267 | (1) |
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267 | (1) |
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268 | (1) |
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10.6.2 Experimental Results |
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269 | (1) |
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269 | (2) |
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271 | (1) |
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272 | (5) |
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273 | (4) |
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11 Ultrasonic Force and Related Microscopies |
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277 | (30) |
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277 | (2) |
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11.2 Mechanical Diode Detection |
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279 | (1) |
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11.3 Experimental UFM Implementation |
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280 | (3) |
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283 | (4) |
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11.5 Quantitative Measurements of Contact Stiffness |
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287 | (2) |
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289 | (4) |
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11.7 Image Interpretation-Effects of Adhesion and Topography |
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293 | (2) |
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295 | (2) |
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11.9 Defects Below the Surface |
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297 | (2) |
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11.10 Time-Resolved Nanoscale Phenomena |
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299 | (8) |
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303 | (1) |
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304 | (3) |
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12 Ultrasonic Atomic Force Microscopy |
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307 | (32) |
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307 | (1) |
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307 | (4) |
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12.2.1 Forced Vibration of Cantilever from the Base |
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307 | (1) |
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12.2.2 Quantitative Information, Directional Control, and Resonance Frequency Tracking |
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308 | (1) |
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12.2.3 Effective Enhancement of Cantilever Stiffness |
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309 | (1) |
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12.2.4 Criterion to Avoid Plastic Deformation |
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309 | (2) |
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311 | (9) |
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311 | (1) |
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12.3.2 Linear Analysis of Stiffness and the Q Factor |
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312 | (2) |
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12.3.3 Linear Theory of Subsurface Imaging |
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314 | (2) |
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12.3.4 Advantage of Appropriate Load |
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316 | (1) |
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12.3.5 Nonlinear Analysis of Spectra |
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316 | (2) |
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318 | (1) |
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12.3.7 Numerical Model with Double Nodes |
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319 | (1) |
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320 | (2) |
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322 | (3) |
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12.5.1 Effort to Avoid Nonlinearity at Tip-Sample Contact |
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322 | (1) |
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12.5.2 Relation between UAFM and UFM |
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323 | (1) |
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12.5.3 Quantitative Evaluation of Elasticity |
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324 | (1) |
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12.6 Observation of Defects in Layered Materials |
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325 | (10) |
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12.6.1 Defects in Graphene Sheets |
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325 | (3) |
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12.6.2 Dislocation in Molybdenum Disulfide |
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328 | (1) |
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12.6.3 Observation of Dislocation Behavior under Different Loads |
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329 | (2) |
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12.6.4 Analysis of Dislocation Motion under Varying Applied Load |
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331 | (2) |
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12.6.5 Model for the Reversible Long-Range Motion of Dislocation |
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333 | (1) |
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12.6.6 Delamination in Microelectronic and Mechanical Devices |
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334 | (1) |
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335 | (4) |
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336 | (3) |
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13 Acoustical Near-Field Imaging |
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339 | (32) |
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13.1 Principle of Near-Field Imaging |
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339 | (3) |
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13.1.1 Early Systems of Acoustical Near-Field Imaging |
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339 | (3) |
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13.2 Near-Field Acoustical Imaging and Atomic Force Microscopy |
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342 | (29) |
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343 | (1) |
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13.2.2 Local Acceleration Microscopy |
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344 | (1) |
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13.2.3 Pulsed-Force Microscopy |
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345 | (1) |
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13.2.4 Atomic Force Acoustic Microscopy or AFM Contact-Resonance Imaging |
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345 | (1) |
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13.2.4.1 Principle of Operation |
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345 | (1) |
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13.2.4.2 Flexural Cantilever Resonances |
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346 | (4) |
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13.2.4.3 Relationship of Contact Stiffness to Indentation Modulus |
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350 | (6) |
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13.2.4.4 Torsional Resonances |
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356 | (1) |
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13.2.4.5 Piezo-mode Imaging |
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357 | (1) |
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13.2.4.6 Nonlinear Contact Resonances and Related Phenomena |
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358 | (1) |
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13.2.4.7 Subsurface Imaging Using Contact Resonances |
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359 | (3) |
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362 | (1) |
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362 | (9) |
| Index |
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371 | |