Eight reviews comprise the latest is a series intended to establish a platform of basic knowledge on which to conduct research into the properties and structural characteristics of antibodies. Mostly American specialists cover the regulation and expression of immunoglobulin heavy chains, antibody-based mechanisms of tumor immunity, the human antibody repertoire, human immunoglobulin repertoires in vivo and evolving specificities in vitro , the molecular dissection of the human antibody repertoire in systemic autoimmunity, immunoglobulin V gene sequence analyses to distinguish two subsets of chronic lymphocytic leukemia B cells, the regulation of B-cell activation by the co-receptors, and B-cell superantigens. Annotation c. Book News, Inc., Portland, OR (booknews.com)