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Biochemical Sensors: (In 2 Parts) [Hardback]

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This book covers the full scope of biochemical sensors and offers a survey of the principles, design and applications of the most popular types of biosensing devices. It is presented in 19 chapters, written by 20 distinguished scientists as well as their co-workers. The topics include the design of signal transducers, signal tags and signal amplification strategies, the structure of biosensing interfaces with new biorecognition elements such as aptamers and DNAzymes, and different newly emerging nanomaterials such as Au nanoclusters, carbon nitride, silicon, upconversion nanoparticles and two-dimensional materials, and the applications in wearable detections, biofuel cells, biomarker analyses, bioimaging, single cell analysis and in vivo sensing.

By discussing recent advances, it is hoped this book will bridge the common gap between research literature and standard textbooks. Research into biochemical sensors and their biomedical applications is proceeding in a number of exciting directions, as reflected by the content. This book is published in honor of the 90th birthday of Professor Shaojun Dong, who performed many pioneering studies on modified electrodes and biochemical biosensors.
About the Editors v
Preface vii
Chapter 1 Biochemical Sensors: Concept, Development and Signal Amplification
1(66)
Huangxian Ju
Jianping Lei
Jinghong Li
1 Introduction
3(2)
2 Development of Biochemical Sensors
5(2)
3 Nanomaterial-Based Signal Amplification
7(17)
4 Biomolecule-Based Signal Amplification
24(16)
5 Signal Amplification in Cell and In Vivo Systems
40(8)
6 Summary and Outlook
48(1)
References
49(18)
Chapter 2 Aptamer-Based Biosensors
67(36)
Mengyi Xiong
Lu Liu
Guoliang Ke
Xiao-Bing Zhang
1 Introduction
68(1)
2 SELEX
69(1)
3 Targets Recognition Modes
70(2)
4 Aptamer-Based Biosensors
72(19)
5 Summary and Outlook
91(2)
References
93(10)
Chapter 3 DNAzyme-Based Biosensors for Metal Ion Detection
103(22)
Lingzi Ma
Juewen Liu
1 Introduction
104(1)
2 Peroxidase DNAzyme Based Metal Sensing
105(4)
3 RNA-Cleaving DNAzyme Based Metal Sensors
109(5)
4 Other DNAzyme Based Metal Sensing
114(2)
5 Practical Aspects of DNAzyme-Based Metal Sensors
116(1)
6 Conclusions
117(1)
References
118(7)
Chapter 4 Electrocheniiluminescence Biochemical Sensors
125(88)
Ruizhong Zhang
Zhifeng Ding
1 Introduction
126(2)
2 Overview on ECL Processes
128(10)
3 Classic ECL Biosensing Methodology
138(7)
4 Signal Amplification Strategies
145(11)
5 New Advances in ECL Biosensing
156(7)
6 Emerging Technology for ECL Biosensing
163(9)
7 Summary and Outlook
172(1)
References
173(40)
Chapter 5 Wearable Chem-Biosensing Device
213(58)
Bin Tang
Jilie Kong
1 Overview of Wearable Technology
214(8)
2 How to Make a Wearable Device
222(14)
3 Modalities of Wearable Chem-Biosensing Devices
236(20)
4 Outlook and Challenges
256(4)
References
260(11)
Chapter 6 Enzymatic Biofuel Cells for Self-Powered Electrochemical Sensors
271(28)
Linlin Wang
Panpan Gai
Jun-Jie Zhu
1 Introduction -
272(1)
2 Enzymatic Biofuel Cells Based Self-Powered Biosensors
273(7)
3 Innovative Self-Powered Biosensing Systems
280(9)
4 Key Challenges and Opportunities
289(1)
References
290(9)
Chapter 7 Cell-Based Biosensors
299(60)
Islam M. Mostafa
Fangxin Du
Baohua Lou
Guobao Xu
1 Introduction
301(3)
2 Types of Cells Used for the Construction of CBBs
304(2)
3 Cell Immobilization Techniques
306(2)
4 Different Applications of CBBs According to Types of Cell Used in Biosensor
308(31)
5 Conclusion and Future Perspectives
339(2)
References
341(18)
Chapter 8 Fluorescent Probes for Imaging of Intracellular Active Small Molecules
359(42)
Bo Tang
1 Introduction
360(1)
2 Fluorescent Probes for ROS
361(12)
3 Fluorescent Probes for RNS
373(7)
4 Fluorescent Probes for RSS
380(9)
5 Summary and Outlook
389(1)
References
389(12)
Chapter 9 Bioimaging and Biosensing in Near-Infrared-II Window
401(52)
Tuanwei Li
Chunyan Li
Kaili Cao
Guangcun Chen
Qiangbin Wang
1 Introduction
402(1)
2 Design and Construction of NIR-II Fluorophores
403(15)
3 NIR-II Fluorophores for Bioimaging
418(7)
4 NIR-II Fluorophores for Biosensing
425(6)
5 Summary and Outiook
431(3)
References
434(19)
Chapter 10 Galvanic Redox Potentiometry for In Vivo Sensing
453(1)
Fei Wu
Cong Xu
Ping Yu
Lanqun Mao
1 Introduction
454(1)
2 Fundamentals of GRP Sensing
455(7)
3 Prototype GRP Sensor for Self-Driven Monitoring of Neurochemical Dynamics In Vivo
462(6)
4 Bipolar GRP Sensor for Neuron-Compatible Electrochemical Measurement In Vivo
468(7)
5 Microelectrode Array (MEA)-Based GRP Sensor for Synchronous Recordings of Chemical and Electrical Signals In Vivo
475(1)
6 Summary
476(1)
References
477(6)
Index 483
About the Editors v
Preface vii
Chapter 1 Au Nanoclusters Based Biosensors
1(2)
Tong Shu
Xueji Zhang
1 Introduction
3(1)
2 Synthesis of AuNCs
4(2)
3 PL Properties of AuNCs
6(4)
4 Self-Assembly of AuNCs
10(9)
5 Sensing Applications of AuNCs
19(24)
6 Conclusion and Outlook
43(2)
References
45(14)
Chapter 2 Gold-Coated Magnetic Nanoparticles as Dispersible Electrochemical Biosensors for Ultrasensitive Biosensing
59(26)
Shreedhar Gautam
Sharmin Hoque
J. Justin Gooding
1 Introduction
60(2)
2 The Challenges of Achieving Ultrasensitive Biosensors
62(3)
3 Magnetic Nanoparticles in Sensing
65(3)
4 Dispersible Electrodes
68(4)
5 Liquid Biopsies
72(2)
6 Dispersible Electrodes for Liquid Biopsy Markers
74(3)
7 Conclusions
77(1)
References
78(7)
Chapter 3 Upconversion Luminescence Based Bio/Chemosensors
85(90)
Zhen Li
Zhihong Liu
1 Introduction
87(1)
2 Upconversion Nanoparticles
88(12)
3 Heterogeneous Analysis
100(8)
4 Homogeneous Analysis
108(42)
5 Summary and Outlook
150(1)
References
151(24)
Chapter 4 Carbon Nitride-Based Biosensors
175(52)
Zhuang Wang
Wei Wei
Yanfei Sben
Songqin Liu
Yuanjian Zhang
1 Introduction
177(3)
2 Synthesis of Carbon Nitride
180(8)
3 Signal Conversion of Carbon Nitride
188(7)
4 Interface Optimization with Biomolecules
195(3)
5 Typical Examples of Carbon Nitride-Based Biosensors
198(8)
6 Outlook
206(5)
References
211(16)
Chapter 5 Silicon-Based Optical Biochemical Sensors
227(84)
Houyu Wang
Yao He
1 Zero-Dimensional Silicon Nanoparticles-Based Biosensors
229(20)
2 Silicon-Based Surface Enhaanced Raman Scattering
249(38)
3 Summary and Outlook
287(2)
References
289(22)
Chapter 6 Two-dimensional Materials-Based Electrochemical Biosensors
311(48)
Shao Su
Qian Li
Chunhai Fan
1 Introduction
312(1)
2 2D Materials-Based Electrochemical Sensors for Environmental Monitoring
313(11)
3 2D Materials-Based Electrochemical Sensors for Food Safety
324(4)
4 2D Materials-Based Electrochemical Sensors for Small Biomolecules Analysis
328(2)
5 2D Materials-Based Electrochemical Sensors for Disease Diagnosis
330(8)
6 Challenges and Future of 2D Materials-Based Electrochemical Sensors
338(1)
References
338(21)
Chapter 7 ChemUuminescence Biosensors for Acute Myocardial Infarction Biomarkers
359(58)
Bingjie Gao
Fang Li
Hua Cui
1 Introduction
361(3)
2 CL Biosensor for the Detection of AMI Biomarkers
364(7)
3 ECL Biosensor for the Detection of AMI Biomarkers
371(19)
4 CL Biosensors Based on Microfluidic Devices for POCT
390(7)
5 Outlook
397(1)
References
398(19)
Chapter 8 CRISPR-Cas Approaches for Diagnostic Applications
417(36)
Henson Lee Tu
Xiao Lu
I-Ming Hsing
1 Introduction
418(2)
2 Development of Diagnostic Tools Based on the Properties of Different CRISPR-Cas Systems
420(19)
3 Conclusions and Outiook
439(2)
References
441(12)
Chapter 9 Advanced Electrochemical Tools for Single-Cell Exocytosis
453(20)
Samuel T. Barlow
Bo Zhang
1 Introduction
454(1)
2 New Electroanalytical Tools for Single-Cell Exocytosis
454(6)
3 Single-Vesicle Electrochemistry
460(2)
4 New Directions in Single-Vesicle Electrochemistry
462(4)
5 Conclusions
466(1)
References
466(7)
Index 473
Huangxian Ju, Changjiang Professor, the director of State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University; Fellows of the International Society of Electrochemistry and the Royal Society of Chemistry. Research interests include analytical biochemistry and nanobiosensing, focusing on signal amplification and life analytical chemistry. 730 papers in peer-reviewed journals (451 papers in journals with IF>5), 26 patents, 4 English books, 7 Chinese books, more than 34000 citations in SCI journals with an h-index of 94 (Google Scholar h-index 103), the first outstanding achievement award of Chinese chemical sensors in 2019, 3 first-class S&T prizes from Jiangsu Province Government, 3 first-class prizes in natural science from Education Ministry of China, 3 first-class S&T prizes from Chinese Association for Instrumental Analysis, 3 second-class and 2 third-class S&T prizes from Jiangsu Province Government. He is also the director of Electroanalytical Chemistry Committee, and vice director of Chemical Sensors Committee, Chinese Society of Instruments; vice directors of Analytical Chemistry Discipline Committee and Organic Analysis Committee, Chinese Chemical Society; vice director of Biosensor Biochip Nanotechnology Committee of Chinese Society of Bioengineering; chief editor of Frontiers in Chemistry: Analytical Chemistry, associate editors of Telomere and Telomerase, Sensors and Journal of Analysis and Testing.

Jinghong Li, Academician of the Chinese Academy of Sciences, is currently a Cheung Kong Professor in the Department of Chemistry at Tsinghua University, China. He is the Head of Analysis Center, Tsinghua University. He received his B.Sc. from University of Science and Technology of China in 1991, and PhD from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 1996. He was a postdoc or research scientist at University of Illinois at Urbana-Champaign, University of California at Santa Barbara, Clemson University, and Evonyx Inc., USA. He has been a professor at CIAC from May 2001 and Tsinghua University from July 2004. His current research interests include electroanalytical chemistry and bioanalysis, nanoanalysis and biosensing, physical electrochemistry and interfacial electrochemistry, material electrochemistry and nanoscopic electrochemistry, energy conversion and storage. He is an Associate Editor or Advisory Board member of Chem. Soc. Rev. (RSC), ACS Sensors (ACS), Biosensors and Bioelectronics, Current Analytical Chemistry, and Small Methods (Wiley-VCH). He has published over 400 papers in international peer-reviewed journals with >50,000 citations, giving him an h-index of 115. He is a Fellow of the Royal Society of Chemistry and a Highly Cited Researcher 20152020 in Chemistry, Materials (Thomson Reuters).