E-raamat: Biological Regulation of the Chondrocytes [Taylor & Francis e-raamat]

Designed to help biologists and researchers gain a better understanding of the cartilaginous tissue physiopathology that may lead to new research directions in pharmacology and therapy. First outlines the different types of the chondrocyte cell, which has been demonstrated to produce and be sensitive to many of the growth factors and cytokines that appear to be regulators of the cartilaginous equilibrium. Then discusses the various biological regulations implicated in chondrocyte functions, especially the modulation of the differentiative properties. Among the topics are extracellular matrix components, cultured chondrocytes and in vitro research, the role of growth factors and cytokines on the modulation of chondrocyte properties, interactions with neighboring cells, and the biochemical and molecular perturbations during repair, ageing, rheumatic diseases, and cancer. Includes extensive bibliographies. Annotation copyright Book News, Inc. Portland, Or.

Biological Regulation of the Chondrocytes provides a comprehensive examination of the various regulations in which cartilaginous cells are involved

Biological Regulation of the Chondrocytes provides a comprehensive examination of the various regulations in which cartilaginous cells are involved. The book's introductory chapter provides an overview of the different types of chondrocyte, while following chapters discuss the various biological regulations implicated in chondrocyte functions, especially the modulation of differentiative properties. Chapters 2 and 3 examine the extracellular matrix components, and Chapter 4 discusses the special case of cultured chondrocytes and the usefulness of in vitro approaches. The following three chapters focus on the complex role of cartilaginous growth factors and cytokines (FGF, TGFB, IGF, and IL1) on the modulation of the chondrocyte properties. Chapter 9 discusses the synoviocyte, and the last four chapters examine the biochemical and molecular perturbations that appear during repair, aging, rheumatic disease, and cancer.

Biological Regulation of the Chondrocytes will benefit rheumatologists, pharmaceutical researchers, physiologists, connective tissue specialists, and students and other researchers in the osteoarticular field.