Drug Development for Cancer and Diabetes: A Path to 2030
focuses on new developments in the discovery of drugs for the treatment of cancer and diabetes. This new book presents important recent advances, emerging trends, and novel innovations for these two world-leading diseases. It is structured in two parts. Part I consists of chapters that explores cancer cell cycle checkpoints, cancer biomarkers, essential drug properties, stages in anti-cancer drug development, and various bioactives that are effective against cancer. Part II presents a complete coverage of important advances and research discoveries in antidiabetic drugs. It details the potentials of medicinal plants and phytocompounds as sources for antidiabetic drugs and highlights the ethnobotanical basis of the compounds.
With chapters written by professionals in the field of phytochemistry and pharmacology from key institutions around the world, this volume provides a wide coverage and will be useful especially for scientists in pharmaceutical field.
| Contributors |
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xv | |
| Abbreviations |
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xix | |
| Foreword |
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xxv | |
| Preface |
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xxvii | |
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PART I CANCER AND LEADS FOR CANCER TREATMENT |
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1 | (216) |
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1 Biomarkers For Screening Of Premalignant Lesions And Therapeutic Surveillance |
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3 | (18) |
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2 Kinase Targets In Cancer Drug Discovery |
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21 | (8) |
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3 Essential Drug Properties And Stages In Anti-Cancer Drug Development |
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29 | (14) |
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4 Plant Constituent As Anti-Cancer Drugs |
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43 | (16) |
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5 Anticancer Properties Of Some Effective Phytochemicals |
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59 | (20) |
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6 Therapeutic Aspects Of Some Extracts And Purified Cardiac Glycosides Obtained From Nerium Oleander L. |
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79 | (16) |
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7 Challenging Compounds Of Some Medicinal Plants Against Cancer |
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95 | (8) |
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8 Medicinal Plants As Therapeutic Agents In The Treatment Of Cancer |
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103 | (14) |
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9 Cytotoxic, Apoptosis Inducing Effects And Anti-Cancerous Drug Candidature Of Jasmonates |
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117 | (12) |
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Ramalingam B. Subramanian |
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10 Apoptosis Activity Of 1,2,-Benzene Dicarboxylic Acid Isolated From Andrographis Paniculata On Kb, Siha And Imr Cancer Cell Line |
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129 | (12) |
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11 Anticancer Drug Discovery From The Indian Spice Box |
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141 | (12) |
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12 Phytochemical Investigation And Evaluation Of Anti-Breast Cancer Activity Of Chloroform Extract Of Tagetes Erecta |
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153 | (14) |
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13 Isolation, Identification And In Silico Evaluation Of Anticancer Activity Of Flavone From Pisum Sativum |
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167 | (10) |
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14 Functional Lead Phytochemicals From The Rutaceae And Zingeiberaceae Plants For Development Of Anticancer Drugs |
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177 | (14) |
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15 In Vitro Anticancer Activity Of Biophytum Sensitivum On Liver Cancer Lines (Hepg2) |
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191 | (8) |
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16 Saffron And Its Active Ingredients: A Natural Product With Potent Anticancer Property |
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199 | (18) |
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PART II ANTIDIABETIC DRUG DISCOVERY |
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217 | (132) |
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17 Effects Of Pterocarpus Marsupium In The Management Of Type 2 Diabetes Mellitus |
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219 | (14) |
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18 Antidiabetic And Antihyperlipidemic Activities Of Cyathea Nilgiriensis (Holttum) On Stz Induced Diabetic Rats |
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233 | (16) |
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19 Antidiabetic Activity Of Drug Loaded Chitosan Nanoparticle |
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249 | (14) |
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20 Antidiabetic Activity Of Silver Nanoparticles Biosynthesized Using Venttiago Maderaspatana Leaf Extract |
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263 | (12) |
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21 Hypoglycemic Activity Of Biophytum Sensitivum Whole Plant Extracts On Alloxan Induced Diabetic Rats |
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275 | (8) |
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22 Antidiabetic Activity Of Ventilago Maderaspatana Leaf Extracts On Stz Induced Diabetic Rats |
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283 | (10) |
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P. Karuppannan K. Saravanan |
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23 Isolation, Identification, And Molecular Docking Of Antidiabetic Compounds Of Cyatheia Nilgiriensis (Holttum) |
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293 | (12) |
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24 Antidiabetic Potentials Of Major Indian Spices: A Review |
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305 | (38) |
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25 Aloe Species: Chemical Composition And Therapeutic Uses In Diabetic Treatment |
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343 | (6) |
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| Index |
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349 | |
K. Saravanan, PhD, is Associate Dean of Academic Affairs and Assistant Professor of Zoology, Nehru Memorial College, an affiliated institution of Bharathidasan University, Tamilnadu, India. He has been engaged in teaching, research, and writing for over 15 years.
Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He has had many roles at New Divine Favor Pharmaceutical Industry Limited, Nigeria, and Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has published research articles on phytochemistry as well as the 3-volume book Phytochemistry with AAP.
Horne Iona Averal, PhD, is Associate Professor at Holy Cross College, Trichy, India. She has received many awards and honors and has been engaged with many academic roles at several colleges and universities. Dr. Averal has published four nucleotide sequences in the NCBI-GENBANK.
S. Kannan, PhD, is a specialist in cancer biology and nanomedicine. He has held many roles at national and international academic and scientific bodies and has published a large number of research articles and books in his field.
S. Elavarasi, PhD, is Assistant Professor at Holy Cross College, an affiliated institution of Bharathidasan University, Tamilnadu, India. She has been engaged in teaching and research for more than eight years. She has published research articles, book chapters, and books.
Bir Bahadur, PhD, was formerly Professor, Chairman, and Head of the Department, as well as Dean of the Faculty of Science at Kakatiya University in Warangal, India. A prolific writer and editor, he received many awards and honors during his long career, including being named as an Eminent Botanist of India.
Rohkem infot Taylor & Francis e-raamatute kohta