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xiii | |
| Preface |
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xv | |
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1 | (14) |
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1 | (4) |
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5 | (1) |
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6 | (4) |
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10 | (1) |
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1.5 Measurements and Sampling |
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11 | (4) |
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12 | (3) |
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15 | (30) |
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15 | (2) |
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2.2 General Dynamic Equation |
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17 | (2) |
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2.2.1 Discrete Particle Size Distribution |
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18 | (1) |
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2.2.2 Continuous Particle Size Distribution |
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19 | (1) |
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2.3 Nucleation: New Particle Formation |
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19 | (7) |
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2.3.1 Classical Nucleation Theory |
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20 | (2) |
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2.3.2 Multicomponent Nucleation |
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22 | (1) |
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2.3.3 Heterogeneous Nucleation |
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23 | (1) |
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2.3.4 Atmospheric Nucleation |
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24 | (2) |
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2.4 Growth by Condensation |
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26 | (1) |
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2.5 Coagulation and Agglomeration |
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27 | (5) |
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2.5.1 Brownian Coagulation |
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28 | (1) |
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28 | (4) |
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2.6 Deposition Mechanisms |
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32 | (6) |
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32 | (1) |
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2.6.2 Gravitational Settling |
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32 | (2) |
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2.6.3 Deposition by Diffusion |
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34 | (1) |
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2.6.4 Deposition by Impaction |
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34 | (1) |
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34 | (1) |
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2.6.6 Atmospheric Aerosol Deposition |
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35 | (1) |
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2.6.7 Deposition in the Human Respiratory Tract |
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36 | (2) |
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38 | (7) |
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2.7.1 Monolayer Resuspension |
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38 | (1) |
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2.7.2 Multilayer Resuspension |
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39 | (2) |
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41 | (4) |
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3 Recommendations for Aerosol Sampling |
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45 | (16) |
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45 | (1) |
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3.2 Guidelines for Standardized Aerosol Sampling |
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46 | (7) |
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3.2.1 General Recommendations |
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46 | (1) |
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3.2.2 Standardization of Aerosol Inlets |
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47 | (2) |
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49 | (4) |
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3.3 Concrete Sampling Configurations |
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53 | (4) |
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3.3.1 General Aspects of Particle Motion |
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53 | (1) |
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3.3.2 Laminar Flow Sampling Configuration |
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54 | (1) |
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3.3.3 Turbulent Flow Sampling Configuration |
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55 | (2) |
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3.4 Artifact-Free Sampling for Organic Carbon Analysis |
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57 | (4) |
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59 | (1) |
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59 | (2) |
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4 Aerosol Instrumentation |
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61 | (28) |
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61 | (1) |
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62 | (1) |
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4.3 Aerosol Sampling Inlets and Transport |
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63 | (1) |
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4.4 Integral Moment Measurement |
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64 | (4) |
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4.4.1 Total Number Concentration Measurement: Condensation Particle Counter (CPC) |
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65 | (1) |
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4.4.2 Total Mass Concentration Measurement: Quartz-Crystal Microbalance (QCM) and Tapered-Element Oscillating Microbalance (TEOM) |
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66 | (1) |
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4.4.3 Light-Scattering Photometers and Nephelometers |
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67 | (1) |
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4.5 Particle Surface Area Measurement |
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68 | (2) |
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4.6 Size-Distribution Measurement |
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70 | (8) |
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4.6.1 Techniques based on Particle--Light Interaction |
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70 | (1) |
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4.6.2 Techniques based on Particle Inertia |
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71 | (3) |
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4.6.3 Techniques based on Particle Electrical Mobility |
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74 | (3) |
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4.6.4 Techniques based on Particle Diffusion |
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77 | (1) |
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4.7 Chemical Composition Measurement |
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78 | (2) |
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80 | (9) |
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82 | (7) |
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89 | (30) |
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89 | (2) |
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5.2 Deposition Mechanisms |
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91 | (13) |
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92 | (4) |
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5.2.2 Diffusional Deposition |
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96 | (2) |
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5.2.3 Deposition by Interception |
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98 | (1) |
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5.2.4 Deposition due to Inertial Impaction |
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99 | (1) |
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5.2.5 Gravitational Deposition |
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100 | (1) |
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5.2.6 Electrostatic Deposition |
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100 | (4) |
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5.3 Factors Affecting Efficiency |
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104 | (5) |
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104 | (2) |
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106 | (3) |
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109 | (1) |
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109 | (1) |
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110 | (9) |
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110 | (3) |
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113 | (6) |
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6 Remote Sensing of Atmospheric Aerosols |
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119 | (34) |
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119 | (1) |
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6.2 Surface-Based Remote Sensing |
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120 | (6) |
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6.2.1 Passive Remote Sensing |
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120 | (6) |
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6.2.2 Active Remote Sensing |
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126 | (1) |
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6.3 Satellite-Based Remote Sensing |
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126 | (15) |
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6.3.1 Passive Remote Sensing |
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127 | (8) |
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6.3.2 Active Spaceborne Lidar |
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135 | (1) |
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6.3.3 Applications of Satellite-Based Aerosol Products |
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136 | (5) |
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6.4 Summary and Future Requirements |
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141 | (12) |
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142 | (1) |
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142 | (11) |
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7 Atmospheric Particle Nucleation |
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153 | (28) |
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153 | (3) |
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7.2 Detection of Atmospheric Nanoparticles |
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156 | (7) |
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7.2.1 Condensation Particle Counting |
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156 | (2) |
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7.2.2 Electrostatic Methods |
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158 | (2) |
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7.2.3 Mass Spectrometric Methods for Cluster Detection |
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160 | (3) |
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7.3 Atmospheric Observations of New Particle Formation |
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163 | (3) |
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163 | (2) |
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165 | (1) |
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7.4 Laboratory Experiments |
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166 | (3) |
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7.4.1 Sulfuric Acid Nucleation |
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166 | (2) |
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7.4.2 Hunt for Compound X |
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168 | (1) |
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7.5 Concluding Remarks and Future Challenges |
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169 | (12) |
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170 | (11) |
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8 Atmospheric Aerosols and Climate Impacts |
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181 | (26) |
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181 | (1) |
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8.2 Global Aerosol Distributions |
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181 | (1) |
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8.3 Aerosol Climate Impacts |
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182 | (4) |
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8.4 Simulations of Global Aerosol Distributions |
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186 | (4) |
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8.5 Extinction of Radiation by Aerosols (Direct Effect) |
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190 | (4) |
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8.5.1 Aerosol Optical Depth and Direct Radiative Forcing of Aerosol Components |
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193 | (1) |
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8.6 Aerosols and Clouds (Indirect Effect) |
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194 | (6) |
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8.6.1 How Aerosols Become CCNs and Grow into Cloud Droplets |
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195 | (5) |
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8.7 Radiative Forcing Estimates |
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200 | (3) |
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203 | (4) |
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203 | (4) |
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9 Air Pollution and Health and the Role of Aerosols |
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207 | (14) |
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207 | (1) |
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208 | (1) |
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9.3 Which Pollution Particle Sizes Are Important? |
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209 | (1) |
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9.4 What Health Outcomes Are Associated with Exposure to Air Pollution? |
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209 | (1) |
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9.5 Sources of Atmospheric Aerosols |
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210 | (1) |
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9.6 Particle Deposition in the Lungs |
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210 | (1) |
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9.7 Aerosol Interaction Mechanisms in the Human Body |
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211 | (4) |
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9.8 Human Respiratory Outcomes and Aerosol Exposure |
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215 | (1) |
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9.9 Cardiovascular Outcomes and Aerosol Exposure |
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215 | (1) |
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9.10 Conclusions and Recommendations |
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216 | (5) |
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216 | (5) |
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10 Pharmaceutical Aerosols and Pulmonary Drug Delivery |
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221 | (50) |
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221 | (2) |
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10.2 Pharmaceutical Aerosols in Disease Treatment |
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223 | (3) |
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223 | (1) |
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10.2.2 Chronic Obstructive Pulmonary Disease |
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224 | (1) |
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224 | (1) |
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10.2.4 Respiratory Tract Infection |
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225 | (1) |
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10.2.5 Beyond the Lung: Systemic Drug Delivery |
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225 | (1) |
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10.3 Aerosol Physicochemical Properties of Importance in Lung Deposition |
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226 | (2) |
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10.4 The Fate of Inhaled Aerosol Particles in the Lung |
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228 | (5) |
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10.4.1 Paracellular Transport |
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229 | (1) |
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10.4.2 Transcellular Transport |
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229 | (1) |
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10.4.3 Carrier-Mediated Transport |
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230 | (1) |
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10.4.4 Models for Determining the Fate of Inhaled Aerosols |
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231 | (2) |
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10.5 Production of Inhalable Particles |
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233 | (4) |
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10.5.1 Particle Attrition and Milling |
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233 | (2) |
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10.5.2 Constructive Particle Production |
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235 | (2) |
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10.6 Aerosol Generation and Delivery Systems for Pulmonary Therapy |
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237 | (16) |
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10.6.1 Nebulised Disease Therapies |
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237 | (4) |
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10.6.2 Pressurised Metered-Dose Inhaler Systems |
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241 | (7) |
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10.6.3 Dry-Powder Inhalation |
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248 | (4) |
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10.6.4 Advancing Drug-Delivery Strategies |
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252 | (1) |
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10.7 Product Performance Testing |
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253 | (2) |
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10.7.1 Total-Emitted-Dose Testing |
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253 | (1) |
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10.7.2 Aerodynamic Particle Size Determination: Inertial Impaction Analysis |
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253 | (2) |
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10.8 Conclusion and Outlook |
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255 | (16) |
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255 | (16) |
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11 Bioaerosols and Hospital Infections |
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271 | (20) |
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11.1 The Importance of Bioaerosols and Infections |
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271 | (1) |
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11.2 Bioaerosol-Related Infections in Hospitals |
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272 | (3) |
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11.3 Bioaerosol Properties and Deposition in Human Respiratory Systems |
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275 | (1) |
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11.4 Chain of Infection and Infection Control in Hospitals |
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275 | (2) |
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11.5 Application of Aerosol Science and Technology in Infection Control |
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277 | (8) |
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11.5.1 Understanding Hospital Aerobiology and Infection Control |
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277 | (3) |
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11.5.2 Bioaerosol Experiments and Models |
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280 | (1) |
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11.5.3 Numerical Analysis of Particle Dispersion in Hospitals |
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281 | (1) |
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11.5.4 Air-Cleaning Technologies |
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282 | (3) |
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285 | (6) |
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285 | (6) |
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12 Nanostructured Material Synthesis in the Gas Phase |
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291 | (36) |
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291 | (1) |
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12.2 Aerosol-Based Synthesis |
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292 | (1) |
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292 | (7) |
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12.4 Flame and Laser Synthesis |
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299 | (3) |
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12.5 Laser-Induced Synthesis |
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302 | (7) |
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12.6 Metal-Powder Combustion |
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309 | (4) |
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313 | (1) |
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12.8 Assembling Useful Nanostructures |
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314 | (8) |
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322 | (5) |
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323 | (4) |
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13 The Safety of Emerging Inorganic and Carbon Nanomaterials |
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327 | (18) |
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327 | (3) |
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13.2 Human Health and Inhaled Persistent Engineered Inorganic and Carbon Nanomaterials |
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330 | (3) |
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13.3 Human Health Hazards and Risks Linked to the Ingestion of Persistent Inorganic Nanomaterials |
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333 | (2) |
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13.4 Ecotoxicity of Persistent Inorganic and Carbon Nanomaterials |
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335 | (1) |
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336 | (9) |
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336 | (9) |
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14 Environmental Health in Built Environments |
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345 | (24) |
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14.1 Environmental Hazards and Built Environments |
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345 | (3) |
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14.2 Particulate Contaminants |
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348 | (3) |
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14.2.1 Transport and Behaviour of Particles in Built Environments |
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349 | (2) |
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351 | (18) |
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14.3.1 Biological Hazards |
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351 | (6) |
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357 | (1) |
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358 | (1) |
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14.3.4 Ventilation and Environmental Hazards |
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359 | (2) |
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14.3.5 Energy-Efficient Built Environments, Climate Change and Environmental Health |
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361 | (1) |
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362 | (7) |
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15 Particle Emissions from Vehicles |
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369 | (24) |
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369 | (1) |
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15.2 Engine Concepts and Technologies |
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370 | (3) |
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370 | (1) |
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15.2.2 Spark-Ignition Engines |
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371 | (1) |
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15.2.3 Compression-Ignition Engines |
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372 | (1) |
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15.2.4 Two-Stroke Engines |
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372 | (1) |
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15.2.5 Gas-Turbine Engines |
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373 | (1) |
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373 | (3) |
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15.3.1 In-Cylinder Formation |
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373 | (2) |
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15.3.2 Evolution in the Exhaust and Aftertreatment Systems |
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375 | (1) |
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15.3.3 Noncombustion Particle Sources |
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375 | (1) |
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15.3.4 Evolution in the Environment |
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376 | (1) |
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15.4 Impact of Vehicle Particle Emissions |
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376 | (2) |
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15.4.1 Health and Environmental Effects |
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376 | (1) |
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376 | (2) |
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15.5 Sampling and Measurement Techniques |
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378 | (7) |
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378 | (1) |
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379 | (1) |
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15.5.3 Solid-Particle-Number Measurement |
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380 | (2) |
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382 | (1) |
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15.5.5 Morphology Determination |
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382 | (3) |
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15.6 Amelioration Techniques |
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385 | (8) |
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385 | (1) |
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15.6.2 Control by Engine Design and Calibration |
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385 | (1) |
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15.6.3 Particulate Filters |
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386 | (2) |
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388 | (1) |
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388 | (5) |
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16 Movement of Bioaerosols in the Atmosphere and the Consequences for Climate and Microbial Evolution |
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393 | (24) |
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393 | (2) |
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16.2 Emission: Launch into the Atmosphere |
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395 | (4) |
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397 | (1) |
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397 | (1) |
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16.2.3 Quantifying Emissions |
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398 | (1) |
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16.3 Transport in the Earth's Boundary Layer |
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399 | (5) |
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16.3.1 Motors of Transport |
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399 | (1) |
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16.3.2 Quantifying Near-Surface Flux |
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400 | (4) |
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16.4 Long-Distance Transport: From the Boundary Layer into the Free Troposphere |
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404 | (2) |
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16.4.1 Scale of Horizontal Long-Distance Transport |
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404 | (1) |
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16.4.2 Altitude of Long-Distance Transport |
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405 | (1) |
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16.5 Interaction of Microbial Aerosols with Atmospheric Processes |
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406 | (1) |
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16.6 Implications of Aerial Transport for Microbial Evolutionary History |
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407 | (10) |
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410 | (7) |
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17 Disinfection of Airborne Organisms by Ultraviolet-C Radiation and Sunlight |
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417 | (24) |
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417 | (1) |
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418 | (1) |
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419 | (2) |
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421 | (2) |
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17.4.1 Bacterial Endospores |
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421 | (1) |
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17.4.2 Vegetative Bacteria |
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422 | (1) |
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423 | (1) |
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17.5 Effects of UV Light on Aerosolized Organisms |
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423 | (6) |
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17.5.1 Cell Damage Caused By UV Radiation |
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423 | (1) |
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424 | (1) |
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17.5.3 Typical Survival Curve for UV Exposure |
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425 | (2) |
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17.5.4 The UV Rate Constant |
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427 | (1) |
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17.5.5 RH and Temperature Effects |
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428 | (1) |
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17.5.6 Bacterial Clusters |
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429 | (1) |
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17.6 Disinfection of Rooms Using UV-C Radiation |
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429 | (1) |
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17.7 Sunlight Exposure Studies |
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430 | (1) |
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17.8 Testing Considerations |
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431 | (4) |
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17.8.1 Test Methodology in Our Laboratory |
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432 | (3) |
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435 | (6) |
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435 | (6) |
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18 Radioactive Aerosols: Tracers of Atmospheric Processes |
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441 | (28) |
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441 | (1) |
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18.2 Origin of Radioactive Aerosols |
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442 | (4) |
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18.2.1 Natural Radionuclides |
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442 | (2) |
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18.2.2 Anthropogenic Radionuclides |
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444 | (2) |
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18.3 Tracers of Atmospheric Processes |
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446 | (11) |
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18.3.1 Transport of Radioactive Aerosols |
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446 | (2) |
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448 | (1) |
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449 | (1) |
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450 | (2) |
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452 | (1) |
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18.3.6 Application of Multitracers |
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452 | (2) |
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18.3.7 Atmospheric Residence Time of Radioactive Aerosols |
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454 | (3) |
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18.4 Tracer of Environmental Change |
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457 | (3) |
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460 | (9) |
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461 | (8) |
| Index |
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469 | |