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E-raamat: Soft Matter V 4 - Membranes: Lipid Bilayers and Red Blood Cells, v. 4, Soft Matter, Volume 4 Lipid Bilayers and Red Blood Cells [Wiley Online]

Edited by (University of Washington, Seattle, USA), Edited by (Forschungszentrum Julich, Ge)
  • Formaat: 265 pages
  • Sari: Soft Matter
  • Ilmumisaeg: 23-Jul-2008
  • Kirjastus: Blackwell Verlag GmbH
  • ISBN-10: 352762337X
  • ISBN-13: 9783527623372
Teised raamatud teemal:
  • Wiley Online
  • Hind: 227,32 €*
  • * hind, mis tagab piiramatu üheaegsete kasutajate arvuga ligipääsu piiramatuks ajaks
Soft Matter V 4 - Membranes: Lipid Bilayers and Red Blood Cells, v. 4, Soft Matter, Volume 4 Lipid Bilayers and Red Blood CellsSuurem pilt
  • Formaat: 265 pages
  • Sari: Soft Matter
  • Ilmumisaeg: 23-Jul-2008
  • Kirjastus: Blackwell Verlag GmbH
  • ISBN-10: 352762337X
  • ISBN-13: 9783527623372
Teised raamatud teemal:
Wiley Online e-raamatudRohkem infot Wiley Online kohta
Raamatu kodulehekülg: https://onlinelibrary.wiley.com/doi/book/10.1002/9783527623372
The fourth volume in this series focuses on biological membrane science, in particular its biophysics. Clearly divided into two parts, the first covers red blood cell shapes, while the second part on molecular simulation provides in-depth information on how to make significant progress with membrane characterization by means of models, and how to refine them by comparing them to experiments.
The result is a highly relevant monograph for both an understanding of the biophysical concepts as well as of novel applications.
List of Contributors
xi
Simulations and Models of Lipid Bilayers
1(82)
Sagar A. Pandit
H. Larry Scott
Introduction
1(5)
Atomistic Models
6(53)
Classical Approximation
6(2)
Molecular Dynamics
8(1)
Forcefields for Lipid Simulations
9(6)
Simulation Considerations and Techniques
15(4)
Molecular Dynamics Simulations of Lipid Bilayers
19(1)
System Construction and Simulation Design
20(5)
Analysis and comparison with Experiments
25(6)
Surface Potential Experiments
31(2)
Radial Distribution Functions
33(4)
Heterogeneous Membrane Simulations
37(7)
Simulations of Ordered Lipid Phases
44(2)
Simulations of Asymmetric lipied Bilayers
46(2)
Equilibrium Monte Carlo Methods
48(2)
Monte Carlo Studies of Lipids
50(8)
Thermodynamic Quantities, Limitations of Atomistic Simulations
58(1)
Coarse Grain Models
59(15)
Simulations Based on Reduced ``Pseudo-Molecular'' Molecular Models
59(1)
Continuum Models
60(4)
MD Based Langevin Dynamcs and Mean Field Theory
64(10)
Sumary
74(9)
References
76(7)
Red Blood Cell Shapes and Shape Transformations: Newtonian Mechanics of a Composite Membrane
83(158)
Gerald Lim H.W.
Michael Wortis
Ranjan Mukhopadhyay
Introduction
84(17)
Overview and History
84(5)
Structure of the Erythrocyte: The Composite Membrane
89(1)
What Fixes the Area and Volume of the Red Cell? Flaccid vs. Turgid Cells
90(3)
Shape Determination for a Flaccid Red Cell at Equilibrium: Membrane-Energy Minimization
93(1)
Ingredients of the Membrane Shape-Energy Functional F [ S]
94(1)
Shape Classes, Stability Boundaries and Phase Diagrams
95(3)
Understanding the SDE Transformation Sequence: Universality and the Bilayer-Couple Hypothesis
98(2)
Perspective and Outline
100(1)
Structure of the Cell Membrane; The SDE Sequence
101(6)
Plasma Membrane
102(2)
Membrane Skeleton
104(1)
More on the SDE Sequence of Cell-Shape Transformations
105(2)
Membrane Energetics
107(15)
Energies of Constraint
108(1)
Bending Energy of the Plasma Membrane
109(4)
Elastic Energy of the Membrane Skeleton
113(4)
Dimensionles Variables and Scaling
117(2)
History: Other Red-cell Models
119(3)
Equations of Membrane Shape Mechanics
122(16)
Introduction
122(2)
Mechanices of the Plasma Membrane
124(1)
Fluid Membrane Without bending Rigidity
125(3)
General Equilibrium Conditions for Membranes with Internal Stresses
128(3)
Fluid Membrane with Bending Rigidity
131(5)
Mechanics of the Membrane Skeleton
136(2)
Calculating Shapes Numerically
138(9)
Construction of an Initial Spherical Net Ssphere
139(1)
Discretization of Fcon [ S]
140(1)
Discretization of Fpm [ s]
141(3)
Discretization of Fms
144(1)
Energy Minimization by the Metropolis Monte Carlo Algorithm
145(2)
Predicted Shapes and Shape Transformations of the RBC
147(33)
Shape classes
148(2)
Shape Transitions, Trajectories and Hysteresis
150(3)
Phase-Trajectory Diagrams
153(8)
Individual Shape Clases and Stability Diagrams
161(19)
Significant Results and Prediction
180(10)
Observed SDE Shape Classes all Occur
181(1)
Reference Shape So of the Membrane Skeleton is an Oblate Spheroid
182(1)
Predicted Hysteresis and Fluctuation Effects in RBC Shape Transformations
183(3)
Strain Distribution over the Membrane Skeleton
186(1)
Large Thermal Fluctuations at the AD-to-E1 Boundaries
186(4)
Discussion and conclusions: The Future
190(12)
Validation of the Bilayer-Couple Hypothesis
191(1)
Generalized Phase Diagrams and Trajectories
192(1)
Sensitivity of Results to Variations of Elastic Parameters
193(1)
Effect of Varying
194(1)
Higher-Order Nonlinear Elastic Terms
194(1)
Understanding the Action of Shape-Change-Inducing Agents
195(1)
Experimental Quantitation of mo
196(2)
Effects of Lateral Inhomogeneity of the Red-Cell Membrane
198(2)
Membrane Mechanics of RBCs of Other Mammals
200(1)
Summary
201(1)
Appendix A Material Parameters and Related Experiments
202(9)
Geometry: Cell Area and Volume
202(1)
Plasma membrane Modli
203(1)
Membrane-Skeleton Moduli
204(1)
Linear Moduli u and k
204(4)
Nonlinear Terms
208(3)
Appendix B Symmetry Sets the Form of Elastic Energies
211(5)
Local Bending Energy
211(3)
Local Elastic Energy of Stretch and Shear
214(2)
Appendix C Differential Geometry and Coordinate Transformations
216(9)
Basic Results from Differential Geometry
217(2)
Coordinate Transformations and Covariant Notation
219(3)
Physical Quantities
222(1)
Variational Approach to Membrane Mechanics
223(2)
Appendix D Mechanical Equations of Membrane Equilibrium
225(16)
Decomposition of the Stress Tensor for Membranes
226(1)
Stress Tensor for the Helfrich Model
226(5)
Inclusion of Gaussian curvature
231(3)
Deformation Matrix M in Curvilinear Coordinates
234(1)
Stress Tensor for the Membrane Skeleton
235(2)
Shape Equation Under Conditions of Axisymmetry: Some Examples
237(4)
References 241(8)
Index 249
Gerhard Gompper received his Ph.D. in Physics at the Ludwig-Maximilians-University of Munich, Germany. After a postdoctoral stay at the University of Washington in Seattle, USA, he returned to Munich for his habilitation. From 1994 to 1999, he held a staff scientist position at the Max-Planck-Institute for Colloid- and Interface Science in Berlin-Teltow. Following this, he was jointly appointed as a director at the Institute for Solid State Physics at the Research Center Juelich and as a full professor at the University of Cologne. He was recently honored with the Erwin-Schroedinger-Award.

Michael Schick obtained his Ph.D. in Physics at Stanford University. After a post-doctoral position at Case Western Reserve University, he joined the faculty of the University of Washington in 1969. He has been honored with a Fellowship in the American Physical Society and a Humboldt Foundation Research Award, which he spent at the Ludwig-Maximilians-University in Munich.
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