This handbook provides clinical guidance to the practicing physician on the diagnosis and treatment of Interstitial Lung Diseases (ILD). A contributed work with invited chapters which draw on the knowledge and experience of recognised global leaders in respiratory medicine, it is authoritative, concise and portable and is intended for use in a fast-paced clinical setting. The book:
offers practical tips and clear guidance for clinicians
provides detailed explanations of the main therapeutic options for each individual ILD
contains high-quality visuals, including radiology and histopathology of the most common as well as some of the rarer ILDs
discusses individual ILDs and has topics common to all including critical care, lung transplantation and palliative care
navigates clinicians through cases with decision making guidelines and algorithms
includes appendices with international practice guidelines, sample patient information sheets and other helpful resources.
Emphasizing how to perform a thorough assessment of an ILD patient for accurate diagnosis and their subsequent effective management, this is both a gold standard text as well as a daily companion for physicians caring for ILD patients. A first-of-its-kind, it will become the go-to guide for all clinicians who manage patients with ILD.
| Foreword |
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ix | |
| Contributors |
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xi | |
| Introduction |
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xv | |
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1 An overview of the classification and diagnosis of interstitial lung disease |
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1 | (10) |
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2 Histopathology of interstitial lung disease: A pattern-based approach |
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11 | (28) |
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3 Using thoracic imaging to diagnose ILD |
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39 | (10) |
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4 Genetics and genomics of idiopathic pulmonary fibrosis |
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49 | (16) |
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5 Clinical evaluation of the patient with suspected ILD |
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65 | (18) |
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6 Role of invasive testing in ILD diagnosis |
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83 | (12) |
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7 General principles of ILD diagnosis and management |
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95 | (18) |
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8 Idiopathic pulmonary fibrosis: Epidemiology, natural history and pathophysiology |
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113 | (22) |
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9 Idiopathic pulmonary fibrosis: How should a confident diagnosis be made? |
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135 | (14) |
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10 Management of idiopathic pulmonary fibrosis |
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149 | (40) |
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Damian A.D. Bruce-Hickman |
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11 Hypersensitivity pneumonitis |
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189 | (20) |
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12 Idiopathic interstitial pneumonias other than idiopathic pulmonary fibrosis |
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209 | (12) |
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13 Eosinophilic interstitial lung disorders |
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221 | (16) |
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14 Interstitial lung disease associated with connective tissue disorders |
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237 | (20) |
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257 | (14) |
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16 Sarcoidosis extra-pulmonary manifestations |
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271 | (18) |
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17 Smoking and interstitial lung disease |
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289 | (22) |
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18 Drug-induced and iatrogenic interstitial lung disease |
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311 | (18) |
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19 Occupation-related ILD |
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329 | (16) |
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20 Pulmonary vasculitis and alveolar haemorrhage syndromes |
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345 | (16) |
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21 Lymphangioleiomyomatosis and other cystic interstitial lung diseases |
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361 | (18) |
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22 Pulmonary alveolar proteinosis |
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379 | (12) |
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23 Rare forms of interstitial lung disease |
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391 | (18) |
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409 | (20) |
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25 Understanding the role of co-morbidities in interstitial lung diseases |
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429 | (22) |
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26 Lung transplantation for ILD |
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451 | (42) |
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27 Diagnosis and management of critical illness in patients with interstitial lung disease |
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493 | (18) |
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| Index |
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511 | |
Muhunthan Thillai, MBBS, MRCP, PhD is Consultant Physician specialising in Interstitial Lung Diseases at Papworth & Cambridge University Hospitals in the United Kingdom. He graduated from St. Marys medical school in 2002 with his medical degree and a BA in medical journalism. He began his training as a junior doctor in London and Oxford where he gained Membership of the Royal College of Physicians. He was then appointed as the Infectious Diseases Fellow on the Map of Medicine project at NHS Connecting for Health and as Editor-in-Chief of Junior Dr magazine, before being awarded a personal Research Training Fellowship from the Wellcome Trust. This allowed him to undertake three years of scientific research into sarcoidosis which culminated in a PhD in Immunology and Proteomics from Imperial College London. He continued his medical training in lung cancer, pulmonary vascular disorders and lung transplantation in Papworth and then in respiratory and general medicine at Addenbrookes Hospital. He subsequently completed an observership in sarcoidosis at the Cleveland Center in the USA before being appointed in 2015 as a Consultant within the Papworth Interstitial Lung Diseases Unit with a specific interest in sarcoidosis. He continues to attend a regular outpatient clinic at Addenbrookes Hospital and maintains ongoing research links with Imperial College London. He has been awarded a number of clinical and research prizes from societies including the Eastern Thoracic Society, Imperial College London and the National Heart and Lung Institute. He is the editor of five books, has written numerous book chapters and research papers in sarcoidosis and has given presentations at several international scientific meetings.
Nik Hirani, BMedSci, BMBS, PhD, MRCP is Senior Clinical Lecturer and Honorary Consultant Physician within the School of Clinical Sciences at the University of Edinburgh in the United Kingdom. He is also Principal Investigator in the research group studying Human Models of Inflammation at the MRC Centre for Inflammation Research. The aims of this group are to study the manipulation of oxygen-sensitive mediators to modify acute lung injury and repair as well as clinical and translational studies in idiopathic pulmonary fibrosis.
David R. Moller, MD is Professor of Medicine at the Johns Hopkins Asthma and Allergy Center, the Johns Hopkins University Hospital in Baltimore, Maryland, USA. He is recognized as a top researcher and clinician in sarcoidosis and has published widely in this area.