"Nanomaterials and nanotechnology are extensively being developed, designed, engineered, tailored, manipulated, explored and investigated for variety of applications in Healthcare, Pharmaceutical, and Biotechnological Research and Innovation area. Nanotechnology based products are rapidly growing and multifunctional engineered nanomaterials (ENM) are emerging as useful tools in biotherapeutics delivery as well. Among various nanomaterials, dendrimers have attracted great attention of scientists and have proved their usefulness and applications in Healthcare, Pharmaceutical, and Biotechnological Research attributed to their unique properties like monodispersity, hyperbranched structure synthesized by controlled chemical reactions, nanometric size and shape. Salient Features: 1. Covers dendrimer advance and future opportunity in nanomedicine with safety and efficacy in development of products 2. Presents overview of recent progress in the field, its advances and bottlenecks, will help researchers to get a general insight of dendrimers applications 3. Provides comprehensive overview of latest research efforts in designing, optimizing, development, scale up of dendrimers mediated delivery systems The proposed book is edited by two well-known researchers in the area of nanomaterials, including dendrimers, carbon nanotubes, quantum dots etc, based drug delivery applications and contribution of vivid chapters from renowned formulator, researcher and academician across the world with their specialization area ofinterest in the field of chemistry, biology, pharmacy and nanomedicine"--
Nanomaterials
and
nanotechnology are extensively being developed, designed, engineered, tailored, manipulated, explored and investigated for variety of applications in Healthcare, Pharmaceutical, and Biotechnological Research and Innovation area. Nanotechnology based products are rapidly growing and
multifunctional engineered nanomaterials (ENM) are emerging as useful tools in biotherapeutics delivery as well.
Among various nanomaterials, dendrimers have attracted great attention of scientists and have proved their usefulness and applications in Healthcare, Pharmaceutical, and Biotechnological Research attributed to their unique properties like monodispersity, hyperbranched structure synthesized by controlled chemical reactions, nanometric size and shape.
Salient Features:
- Covers dendrimer advance and future opportunity in nanomedicine with safety and efficacy in development of products
- Presents overview of recent progress in the field, its advances and bottlenecks, will help researchers to get a general insight of dendrimers applications
- Provides comprehensive overview of latest research efforts in designing, optimizing, development, scale up of dendrimers mediated delivery systems
The proposed book is edited by two well-known researchers in the area of nanomaterials, including dendrimers, carbon nanotubes, quantum dots etc, based drug delivery applications and contribution of vivid chapters from renowned formulator, researcher and academician across the world with their specialization area of interest in the field of chemistry, biology, pharmacy and nanomedicine.
Preface |
|
vii | |
Editors |
|
ix | |
Contributors |
|
xi | |
|
1 Nanotechnology: Introduction And Basic Concepts |
|
|
1 | (18) |
|
|
|
|
|
2 Fundamental Aspects Of Targeted Drug Delivery |
|
|
19 | (22) |
|
|
|
|
|
|
|
|
3 Dendrimers In Nanomedicine: History, Concept And Properties Of Dendrimers |
|
|
41 | (12) |
|
|
4 Classification And Types Of Dendrimers: Introduction And Chemistry |
|
|
53 | (24) |
|
|
|
5 Macromolecular Architecture And Molecular Modelling Of Dendrimers |
|
|
77 | (12) |
|
|
|
|
|
|
6 Synthesis Of Dendrimers |
|
|
89 | (34) |
|
|
|
7 Functionalisation Of Dendrimers |
|
|
123 | (24) |
|
|
|
|
8 Characterisation Of Dendrimers: Methods And Tools |
|
|
147 | (24) |
|
|
|
9 Dendrimer-Guest Interaction Chemistry And Mechanism |
|
|
171 | (16) |
|
|
|
|
|
10 Dendrimers In Gene Delivery |
|
|
187 | (14) |
|
|
|
|
11 Dendrimers In Diagnostics Application |
|
|
201 | (16) |
|
|
|
|
12 Dendrimer-Nanomaterial Conjugation: Concept, Chemistry And Applications |
|
|
217 | (16) |
|
|
|
|
|
13 Smart Functionalised-Dendrimeric Medicine In Cancer Therapy |
|
|
233 | (22) |
|
|
|
|
14 Drug Delivery Potential Of Dendrimeric Formulation |
|
|
255 | (22) |
|
|
Mohammad Akhlaquer Rahman |
|
|
|
|
|
|
|
15 Biomedical Applications Of Dendrimers |
|
|
277 | (10) |
|
|
|
16 Biodistribution, Toxicity And Regulatory Considerations Of Dendrimers |
|
|
287 | (24) |
|
|
Index |
|
311 | |
Dr. Neelesh Kumar Mehra is working as Assistant Professor of Pharmaceutics, at Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He earned his PhD with Prof. N.K. Jain from Dr. H.S. Gour University, Sagar and PostDoc from Texas A & M Health Science Centre, Kingsville, TX, USA. He served as Manager in Product Development, Sentiss Pharma Pvt Ltd. Gurgaon for development, scale-up and technology transfer of complex ophthalmic, inhalation, and otic pharmaceutical products. He received "TEAM AWARD" for successfully commercialization of Ophthalmic Suspension product. He is as an Editorial member of "Drug Delivery Letters" Journal, Bentham sciences. He has authored more than 50 peer-reviewed publications in high repute International Journals, 07 book chapters contributions. He guided PhD and M.S. students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist, Team Awards for their research output. He is peer reviewer of various international Journals and publishers. Currently he is editing books on Biopharmaceutical and nanotechnology based with CRC Press and Elsevier Pvt Ltd. He has 11 years rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nano-technologies for regulated market and so on.
Dr. Keerti Jain earned her M. Pharm. and doctorate degree from Dr. H. S. Gour Central University, Sagar. She did her Post Doctorate from M. S. University of Vadodara, India as SERB-National Post-Doctoral Fellow. She has more 10 years of research experienced on Nanomedicine based drug delivery systems. Currently, she is efficiently fulfilling her responsibilities as Asst. Prof. and Scientists at Department of Pharmaceutics, NIPER, Rae Bareli, Lucknow, UP INDIA. Dr. Jain has supervised M. Pharm. and Pharm. D. students for their research works which have been published in quality journals with good impact factor. She is author of more than 60 international manuscripts in peer reviewed-high impact journals, including publications in Progress in Polymer Science having impact factor: 26.932, in biomaterials, drug discovery today, nanomedicine Current Opinion in Pharmacology, Antimicrobial agents and chemotherapy and other high impact factors. Her review articles entitled "Dendrimer Toxicity: Lets Meet the Challenge" and "Dendrimers as Nanocarriers in Drug Delivery" published in International Journal of Pharmaceutics (2010) and Progress in Polymer Science (2014) was listed in top 25 articles. She has been author of 10 books and book chapters with international publishers. She has been awarded with research fellowships including SERB Post Doctorate Fellowship, Senior research fellowship (CSIR), Junior research fellowship (UGC), Fellowship for training of young scientist (MPCST), Travel grant award (INSA) and International Travel Fellowship (ICMR and DBT) apart from several other prestigious grants, fellowships and awards. She has been nominated for Ranbaxy Research Scholar Award 2012 and BioAsia Innovation Award 2015. She has also been awarded with many best research presentation award in international conferences like NIPiCON-2014, International Science Congress-2012, APTI Jaipur 2018, SPER-Bangkok 2019 and so on. She has been recipient of Pharmaceutical Science Alumni Award-2006 at Dr. H. S. Gour University, Sagar (M.P.). Till date she has been invited to present her research work at several national and seven international conferences including ICYRAM-2012 held at Singapore, Bioencapsulation 2016 held at Lisbon, Portugal and International Conference 2019 held at Bangkok. She won most innovative Idea award in LUFTHANSA impact week, which is a Reputed international platform.