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E-raamat: Flexible Viruses - Structural Disorder in Viral Proteins: Structural Disorder in Viral Proteins [Wiley Online]

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This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
Preface ix
Introduction to the Wiley Series on Protein and Peptide Science xv
Contributors xvii
1 Do Viral Proteins Possess Unique Features?
1(34)
Bin Xue
Robert W. Williams
Christopher J. Oldfield
Gerard K.-M. Goh
A. Keith Dunker
Vladimir N. Uversky
2 Functional Role of Structural Disorder in Capsid Proteins
35(12)
Lars Liljas
3 Structural Disorder Within the Nucleoprotein and Phosphoprotein from Measles, Nipah, and Hendra Viruses
47(48)
Johnny Habchi
Laurent Mamelli
Sonia Longhi
4 Structural Disorder Within Sendai Virus Nucleoprotein and Phosphoprotein
95(20)
Malene Ringkjøbing Jensen
Pau Bernadø
Rob W.H. Ruigrok
Martin Blackledge
5 Structural Disorder in Proteins of the Rhabdoviridae Replication Complex
115(28)
Cedric Leyrat
Francine C.A. Gerard
Euripedes A. Ribeiro, Jr.
Ivan Ivanov
Marc Jamin
6 Structural Disorder in Matrix Proteins of HIV-Related Viruses
143(26)
Gerard K.-M. Goh
Bin Xue
A. Keith Dunker
Vladimir N. Uversky
7 Structural Disorder in Proteins From Influenza Virus
169(32)
Gerard K.-M. Goh
Bin Xue
A.K. Dunker
Vladinir N. Uversky
8 Making Order in the Intrinsically Disordered Regions of HIV-1 Vif Protein
201(22)
Tali H. Reingewertz
Deborah E. Shalev
Assaf Friedler
9 Order from Disorder: Structure, Function, and Dynamics of the HIV-1 Transactivator of Transcription
223(34)
Shaheen Shojania
Joe D. O'Neil
10 Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins
257(20)
Smita Nair
M.R.N. Murthy
H.S. Savithri
11 Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses
277(36)
Jadwiga Chroboczek
Eugenie Hebrard
Kristiina Makinen
Thierry Michon
Kinmo Rantalainen
12 Intrinsic Disorder in the Human Papillomavirus E7 Protein
313(34)
Lucia B. Chemes
Ignacio E. Sanchez
Leonardo G. Alonso
Gonzalo de Prat-Gay
13 The Semliki Forest Virus Capsid Protease is Disordered and Yet Displays Catalytic Activity
347(28)
Manuel Morillas
Heike Eberl
Frederic H.-T. Allain
Rudi Glockshuber
Eva Kuennemann
14 Core-lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses
375(34)
Roland Ivanyi-Nagy
Eve-Isabelle Pecheur
Jean-Luc Darlix
15 The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes
409(16)
Xavier Hanoulle
Isabelle Huvent
Arnaud Leroy
Hong Ye
Cong Bao Kang
Yu Liang
Claire Rosnoblet
Jean-Michel Wieruszeski
Ho Sup Yoon
Guy Lippens
16 Bacteriophage λ N Protein Disorder-Order Transitions Upon Interactions with RNA or Proteins
425(20)
Kristian Schweimer
Paul Rosch
17 N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure
445(28)
Valentin V. Makarov
Michael E. Taliansky
Eugeny N. Dobrov
Natalia O. Kalinina
Index 473
VLADIMIR N. UVERSKY is an Associate Professor at the Department of Molecular Medicine at the University of South Florida (USF). He obtained his academic degrees from Moscow Institute of Physics and Technology (PhD in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (DSc in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and Institute for Biological Instrumentation, Russia. In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. He has authored over 400 scientific publications and edited several books and book series on protein structure, function, folding and misfolding.

SONIA LONGHI is a Director of Research at the Center for the National Scientific Research (CNRS). She obtained her academic degree (PhD) from the University of Milan in 1993. She then went to the Architecture and Function of Biological Macromolecules laboratory (AFMB, UMR 6098, CNRS and Aix-Marseille University) where she did postdoctoral work on protein crystallography. Since 2006, she has been heading the "Structural Disorder and Molecular Recognition" group within the AFMB laboratory. She has authored more than 70 scientific publications and edited a book on measles virus nucleoprotein and coedited, with Prof. Vladimir Uversky, a book entitled Instrumental Analysis of Intrinsically Disordered Proteins (Wiley).