Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.
Scope and limitations of gene therapy, K. Sikora. Tissue-directed gene
delivery systems, C.R. Middaugh et al. Retroviral vectors, W.H. Gunzburg and
B. Salmons. Adenovirus vectors, C.J.A. Ring. Adeno-associated virus vectors
for human gene therapy, J.S. Bartlett and R.J. Samulski. Liposome delivery
systems, R.K. Scheule and S.H. Cheng. Development of mammalian artificial
chromosome vectors: prospects for somatic gene transfer, Z. Larin. Infectious
herpes vectors for gene therapy, J.-M.H. Vos et al. Role of animal models in
gene therapy, J.R. Dorin and D.J. Porteous. Gene targeting as an approach to
gene therapy, A. Porter. Cystic fibrosis, N.J. Caplen and E.W.F.W. Alton.
Gene therapy for haemophilia B, K. Kurachi and J.-M. Wang. Gene therapy for
adenosine deaminase deficiency, H.B. Gaspar and C. Kinnon. Cardiovascular
disease, B.A. French. Cancer gene therapy I: genetic intervention strategies,
L.-A. Martin and N.R. Lemoine. Cancer gene therapy II: immunomodulation
strategies, J. Galea-Lauri and J. Gaken. The muscular dystrophies, C.A. Sewry
and T.A. Partridge. Recent developments in gene therapy for neurological
disorders, P.R. Lowenstein.
Cooper, David; Lemoine, Prof Nick
Rohkem infot Taylor & Francis e-raamatute kohta