Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.
The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
PART I. BIOLOGY OF SKIN AND HAIR OF LABORATORY MICE AND HUMAN BEINGS --
Introduction -
Chapter
1. Applications and Needs of Models for
Dermatological Research /Lowell A. Goldsmith -
Chapter
2. Inbred Laboratory
Mice as AnimaJ Models and Biomedical Tools: General Concepts /John P.
Sundberg -
Chapter
3. The Jackson Laboratory Mouse Mutant Resource /Muriel
T. Davisson -
Chapter
4. Hair Follicle Stem Cells /Robert M. Lavker,
Tung-Tien Sun, and John P. Sundberg -
Chapter
5. The Mouse Skin as a Model
for Chemical Carcinogenesis /Claudio J. Conti -
Chapter
6. Viral Induced
Skin Tumors in Mice /John P. Sundberg, Hendrick G. Bedigian, and Roderick
Bronson -
Chapter
7. Hair Types and Subtypes in the Laboratory Mouse /John
P. Sundberg and Margaret E. Hogan -
Chapter
8. Growth Factors and Cutaneous
Pathology /Lloyd E. King, Jr., Lillian B. Nanney, and Ronald E. Gates --
Chapter
9. Transgenic Mice with Cytokine Mutations Affecting the Skin
/Manfred Blessing, Erby Wilkinson, and Brigid L. M. Hogan -
Chapter
10.
Epidermal Keratins /Joseph A. Rothnagel and Dennis R. Roop -
Chapter 1
1.
Hair Follicle Keratins /George E. Rogers and Barry C. Powell -
Chapter
12.
Keratinocyte Cultures as Models for DermatologicaJ Disease /Mark R. Pittelkow
-
Chapter
13. Mouse Mutations with Endocrine Functional Consequences /Wesley
G. Beamer -
Chapter
14. The Immune System in Cutaneous Disease: the Search
for a Mouse Model of the Lmmunopathology of Psoriasis /Susan F. Grammer and
J. Wayne Streilein -- PART II. ANIMAL MODELS OF GENETIC BASED SKIN DISEASES
Section A. Mouse Single Gene Mutations -- Introduction -
Chapter
1. The
Adrenocortical Dysplasia (acd) Mutation, Chromosome 8 /John P. Sundberg, Seth
J. Orlow, Hope O. Sweet, and Wesley G. Beamer -
Chapter
2. The Angora (go)
Mutation, Chromosome 5 /John P. Sundberg -
Chapter
3. The Asebia (ab, ab1)
Mutations, Chromosome 19 /John P. Sundberg -
Chapter
4. The Atrichosis (at)
Mutation, Chromosome 10 /John P. Sundberg -
Chapter
5. The Balding (bal)
Mutation, Chromosome 18 /John P. Sundberg -
Chapter
6. The Bare-Patches
(Bpa) Mutation, Chromosome X /John P. Sundberg -
Chapter
7. The Bareskin
(Bsk) Mutation, Chromosome 11 /John P. Sundberg -
Chapter
8. The Beige (bg)
Mutation, Chromosome 13 /John P. Sundberg -
Chapter
9. The Caracul (Ca and
Cad) Mutations, Chromosome 15 /John P. Sundberg and Hope O. Sweet -
Chapter
10. The Chronic Proliferative Dermatitis (cpd) Mutation, Chromosome ?. Harm
HogenEsch, Marion J. J. Gijbels, and Chris Zurcher -
Chapter
11. The
Crinkled (cr) Mutation, Chromosome 13 /John P. Sundberg -
Chapter
12. The
Curly-Whiskers (cw) Mutation, Chromosome 9 /John P. Sundberg -
Chapter
13.
The Depilated (dep) Mutation, Chromosome 4 /John P. Sundberg and Seth J.
Orlow -
Chapter
14. The Downless (dl) and Sleek (Dlslk) Mutations,
Chromosome 10 /John P. Sundberg -
Chapter
15. The Ferrochelatase Deficiency
(FechmlPas) Mutation, Chromosome 18 /Xavier Montagutelli -
Chapter
16. The
Flaky Skin (fsn) Mutation, Chromosome? /John P. Sundberg, Dawnalyn Boggess,
Leonard D. Shultz, and Wesley G. Beamer -
Chapter
17. The Flaky Tail (ft)
Mutation, Chromosome 3 /John P. Sundberg -
Chapter
18. The Frizzy (fr)
Mutation, Chromosome 7 /John P. Sundberg -
Chapter
19. The Fuzzy (fz)
Mutation, Chromosome 1 /John P. Sundberg -
Chapter
20. The Greasy (Gs)
Mutation, Chromosome X /John P. Sundberg -
Chapter
21. The Hair Interior
Defect (hid) Mutation, Chromosome? /John P. Sundberg -
Chapter
22. The
Hairless (hr) and Rhino (hrrh) Mutations, Chromosome 14 /John P. Sundberg --
Chapter
23. The Hair Patches (Hpt) Mutation, Chromosome 4 /John P. Sundberg
-
Chapter
24. The Hairy Ears (Eh) Mutation, Chromosome 15 /John P. Sundberg
and Seth J. Orlow -
Chapter
25. The Harlequin (Hq) Mutation, Chromosome X
/John P. Sundberg -
Chapter
26. The Ichthyosis (ic) Mutation, Chromosome 1
/John P. Sundberg and Mark R. Pittelkow -
Chapter
27. The Lethal Milk (Im)
Mutation, Chromosome 2 /John P. Sundberg and Hope O. Sweet -
Chapter
28. The
Lustrous ( / /) Mutation, Chromosome 11 /John P. Sundberg -
Chapter
29. The
Matted (ma) Mutation, Chromosome 3 /John P. Sundberg -
Chapter
30. The
Motheaten (me) and Viable Motheaten (mev) Mutations, Chromosome 6 /Leonard D.
Shultz and John P. Sundberg -
Chapter
31. The Mottled Locus: Mottled (Mo),
Blotchy (Mobl°), Brindled (Mobr), Dappled (Modp), Mosaic (Moms),
Tortoiseshell (Mow), and Viable Brindled (Movbr) Mutations, Chromosome X / --
John P. Sundberg -
Chapter
32. The Naked (N) Mutation, Chromosome 15 /John
P. Sundberg -
Chapter
33. The Nude (nu) and Streaker (nustr) Mutations,
Chromosome 11 /John P. Sundberg -
Chapter
34. The Ragged (Ra) and Opossum
(Raop) Mutations, Chromosome 2 /John P. Sundberg -
Chapter
35. The Repeated
Epilation (Er) Mutation, Chromosome 4 /Jean-Louis Guenet, Josselyne Salaun,
and Berthe Salzgeber -
Chapter
36. The Rex (Re), Wavy Coat (Rewl), and
Denuded (Reden) Mutations, Chromosome 11 /John P. Sundberg -
Chapter
37. The
Satin (sa) Mutation, Chromosome 13 /John P. Sundberg -
Chapter
38. The
Scurfy (sf) Mutation, Chromosome X /Virginia L. Godfrey -
Chapter
39. The
Severe Combined Immunodeficiency (scid) Mutation, Chromosome 16 /John P.
Sundberg and Leonard D. Shultz -
Chapter
40. The Shaven (Sha) Mutation,
Chromosome 15 /John P. Sundberg -
Chapter
41. The Silver (si) Mutation,
Chromosome 10 /Seth J. Orlow and John P. Sundberg -
Chapter
42. The Soft
Coat (soc) Mutation, Chromosome 3 /John P. Sundberg -
Chapter
43. The
Sparse-Coat (spc) Mutation, Chromosome 14 /John P. Sundberg -
Chapter
44.
The Sparse-Fur (Otcspf) and Abnormal Skin and Hair (Otcash) Mutations,
Chromosome X /John P. Sundberg and Donald P. Doolittle -
Chapter
45. The
Tabby (Ta), Tabby-c (Tal), and Tabby-J (TaJ) Mutations, Chromosome X /John P.
Sundberg -
Chapter
46. The Tight-Skin (Tsk) Mutation, Chromosome 2 /John P.
Sundberg -
Chapter
47. The Vitiligo (mivu) Mutant Allele of the
Microphthalmia Locus, Chromosome 6 /M. Lynn Lamoreux and Seth J. Orlow --
Chapter
48. The Wellhaarig (we, weMr) Mutations, Chromosome 2 /John P.
Sundberg -- Section B. Purported Polygenic Mouse Skin Diseases --
Introduction -
Chapter
1. Chronic Ulcerative Dermatitis in Black Mice /John
P. Sundberg, Kathy S. Brown, and William M. McMahon -
Chapter
2. Barbering
Behavioral Abnormalities in Inbred Laboratory Mice /William M. McMahon and
John P. Sundberg -
Chapter
3. Alopecia Areata in Aging C3H /HeJ Mice /John
P. Sundberg, Colleen M. Vallee, and Lloyd E. King, Jr. -- Section C.
Nonmurine Animal Models of Genetic Based Skin Diseases -
Chapter
1. Selected
Heritable Skin Diseases of Domesticated Animals /Robert W. Dunstan and Robert
A. Kennis -- Index.
John P. Sundberg, D.V.M., Ph.D., is Head of the Pathology program at the Jackson Laboratory in Bar Harbor, Maine. Dr. Sundberg graduated in 1973 from the University of Vermont with a B.S. degree in Animal Science (summa cum laude) and obtained his D.V.M. degree in 1977 from Purdue University School of Veterinary Medicine, West Lafayette, Indiana. Following a brief period in private practice. Dr. Sundberg earned a Ph.D. degree in comparative pathology in 1981 from The University of Connecticut in Storrs. Dr. Sundberg served as an assistant professor at the University of Illinois College of Veterinary Medicine from 1981 to 1986. In 1986 he assumed his present position. Dr. Sundberg is a diplomate of the American College of Veterinary Pathologists. He is a member of the American Veterinary Medical Association, American Association for Laboratory Animal Science, Society for Investigative Dermatology, Hair Research Society, New England Veterinary Pathology Colloquy, and the Maine Veterinary Medical Association. Dr. Sundberg has been the recipient of research grants from the National Institutes of Health, American Cancer Society, National Alopecia Areata Foundation, and private industry. He has published over 125 research and clinical papers, 50 technical bulletins, and 15 book chapters. His current major research interests relate to mouse mutations as models of human and animal diseases, the comparative pathology and molecular evolution of nonhuman papillomaviruses, and spontaneous diseases of inbred laboratory mice.
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