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E-raamat: Hormone Replacement Therapy and Cancer: The Current Status of Research and Practice [Taylor & Francis e-raamat]

(University of Pisa, Pisa, Italy)
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Drawn from the second International Menopause Society workshop held in Pisa, Italy, these 33 contributions by leading experts in the field address knowledge current as of June 2001 relevant to the controversy over hormone replacement therapy's role as a cancer activator. After several papers describing the genetic processes underlying carcinogenesis, the discussion turns to HRT's relationship to specific cancers: breast, endometrial, colon, melanoma, and ovarian. The final section weighs the benefits and risks of newer forms of HRT. Genazzani (obstetrics and gynecology, U. of Pisa) is president of the International Menopause Society, under whose auspices this volume is published. Annotation c. Book News, Inc., Portland, OR (booknews.com)

The clinical benefits of hormone replacement therapy in women have to be carefully balanced against the possible risks, and a particular theoretical concern relates to risks associated with various forms of female oncology. Because of conflicting reports, gynecologists and oncologists especially need a single, authoritative resource of up-to-date information. Hormone Replacement Therapy and Cancer, published in association with the International Menopause Society, provides the very consensus statement that clinicians need in this difficult and complex area.

Many of the world's leading specialists have contributed important chapters that provide state-of-the-art knowledge about the effects of hormones on women and possible cancer risks. The introductory section deals with carcinogenesis, and the other main sections cover HRT and breast cancer, endometrial cancer, colon cancer, melanoma and epithelial ovarian cancer. The concluding chapters discuss the benefits and risks of sp ecific therapies. An authoritative clinical reference with extensive bibliographic references and index, Hormone Replacement Therapy and Cancer covers all aspects of HRT and cancer based on the research available up to June 2001.
List of principal contributors
ix
Section I: Carcinogenesis
Oncogenes and tumor suppressor genes
1(9)
S. Giordano
S. Corso
P. Conrotto
Telomerase and cancer
10(7)
S. S. R. Banik
C. M. Counter
Matrix metalloproteinases
17(8)
S. McDonnell
A. O'Connor
D. Murray
C. C. Lynch
Biological basis of angiogenesis and role of vascular endothelial growth factor-D
25(6)
S. Oliviero
Section II: HRT and breast cancer
Breast cancer: epidemiology, pathology and natural history
31(7)
R. K. Ross
Genes and heredity in breast cancer
38(6)
G. Bevilacqua
Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant breast epithelium
44(10)
J. R. Pasqualini
G. S. Chetrite
Chemoprevention of breast cancer with tamoxifen: recent experience and future perspectives
54(7)
B. Bonanni
A. Guerrieri-Gonzaga
N. Rotmensz
A. Decensi
Hormonal therapy of breast cancer
61(11)
A. Hamilton
Hormone replacement therapy and mammographic breast density
72(6)
B. von Schoultz
E. Lundstrom
Hormone replacement therapy, insulin-like growth factor I and breast cancer
78(8)
P. Sismondi
N. Biglia
R. Ponzone
S. Ambroggio
Postmenopausal hormone use and breast cancer risk: reassessment of the evidence
86(9)
P. Kenemans
G.A. van Unnik
The use of hormonal therapy for management of severe postmenopausal symptoms following breast cancer
95(10)
B. G. Wren
Section III: HRT and endometrial cancer
Endometrial cancer: epidemiology, pathology and natural history
105(10)
J. Prat
Endocrine, paracrine and intracrine mechanisms of growth regulation in normal and malignant endometrial epithelium
115(10)
E.-M. Rutanen
Chemoprevention and endocrine therapy of endometrial carcinoma
125(10)
A. R. Genazzani
A. Gadducci
Hormone replacement therapy and endometrial cancer
135(13)
C. W. Burger
G. A. van Unnik
P. Kenemans
Endometrial stromal tumors - are they hormonally sensitive?
148(7)
P. E. Schwartz
M. C. Chu
W. Zheng
G. Mor
Section IV: HRT and colon cancer
Epidemiology of colorectal cancer
155(6)
M. E. Leon
P. Boyle
Colon cancer: Pathology and natural history
161(11)
F. Tonelli
Estrogen receptors, estrogens and colon cancer
172(6)
F. Al-Azzawi
Cyclo-oxygenase-2: an endogenous tumor promoter and target for the chemoprevention of colorectal cancer and other neoplastic diseases
178(13)
F. Marks
G. Furstenberger
K. Muller-Decker
Hormone replacement therapy and colon cancer
191(7)
A. H. Wu
Section V: HRT and melanoma
Cutaneous malignant melanoma: epidemiology, endocrine features and hormone replacement therapy
198(9)
A. Gadducci
A. R. Genazzani
Section VI: HRT and epithelial ovarian cancer
BRCA1-BRCA2 and ovarian cancer
207(11)
S. Greggi
Estrogen replacement therapy use and risk of ovarian cancer: results from two Italian studies and review of the literature
218(4)
F. Parazzini
G. Polverino
S. Cipriani
E. Ricci
F. Chiaffarino
C. La Vecchia
Section VII: Selective aspects of specific therapies
Understanding HRT risks and benefits and the new science of HRT
222(13)
J. V. Fiorica
Pulsed estrogen therapy may lead to lower breast stimulation than with daily continuous estrogen exposure
235(6)
N. Mabon
C. Varin
Y. Tsouderos
Transdermal estrogen therapy and the risk of breast cancer: a clinical appraisal
241(8)
M. Notelovitz
The effects of selective estrogen receptor modulators on the endometrium
249(3)
S. R. Goldstein
Safety and tolerability profile of Livial
252(5)
F. A. Helmond
H. J. Kloosterboer
Preclinical and clinical development of new progesterone receptor antagonists with high receptor specificity for breast cancer treatment
257(8)
J. Hoffmann
H. Hess-Stumpp
R. B. Lichtner
U. Fuhrmann
G. Siemeister
M. R. Schneider
More than bones: hormone replacement therapy for mind and body
265(8)
J. M. Alt
Index 273


Andrea R. Genazzani (Author)