Tasuta saatmine! | Klienditugi: 7440010 (E-R 10-18)

Abi | Registreeri | Logi sisse

E-raamat: Immunological Basis of Asthma [Taylor & Francis e-raamat]

Edited by Bart Lambrecht, Edited by Zuzana Diamant, Edited by Henk Hoogsteden

Formaat: 840 pages
Ilmumisaeg: 19-Jun-2019
Kirjastus: CRC Press
ISBN-13: 9780429150609

Teised raamatud teemal:

Taylor & Francis e-raamat
Hind: 281,59 €*
* hind, mis tagab piiramatu üheaegsete kasutajate arvuga ligipääsu piiramatuks ajaks
Tavahind: 402,26 €
Säästad 30%

Formaat: 840 pages
Ilmumisaeg: 19-Jun-2019
Kirjastus: CRC Press
ISBN-13: 9780429150609

Teised raamatud teemal:

Rohkem infot Taylor & Francis e-raamatute kohta

Raamatu kodulehekülg: https://www.taylorfrancis.com/books/9780429150609

This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and allergic diseases,and offers unparalleled research from nearly 60 international contributors.

Introduction

Preface

vii

Contributors

Part One The Cells Of The Pulmonary Immune Response

1 Overview of the Pulmonary Immune Response

(18)

Laurent P. Nicod

I Introduction

(1)

II The Airways and the Mucociliary Apparatus

(2)

III The Mucosa and Submucosa

(3)

IV Immune Response in the Alveolar Spaces

(5)

V Mast Cells and Basophils

(1)

References

(6)

2 Antigen-Presenting Cells

(34)

Henk C. Hoogsteden

Hamida Hammad

Bart N. Lambrecht

I Introduction

(1)

II Dendritic Cells

(19)

III Macrophages

(3)

IV Conclusion

(1)

References

(11)

3 CD4 T Lymphocytes in Allergic Asthma

(30)

Mark Larche

A. Barry Kay

I Introduction

(1)

II A Historical Perspective of the CD4 T Cell in Asthma

(1)

III Antigen Recognition by T Cells

(1)

IV Effect of Allergen Dose and Genetic Background on the Development of T-Cell Responses

(1)

V Effects of Affinity on the Development of T-Cell Responses

(1)

VI Factors Influencing T-Helper-Cell Differentiation

(1)

VII T-Cell Homing to the Lung

(1)

VIII Th2 Cytokines in Asthma

(3)

IX Exploring the Role of T Cells in Asthma Using Animal Models

(2)

X Pharmacological Intervention as a Tool for Defining the Role of the T Cell in Asthma

(1)

XI Induction of Isolated Late Asthmatic Reactions with Allergen Peptides

(1)

XII MHC Restriction of Peptide-Induced LAR

(1)

XIII Mechanisms Underlying Isolated LAR

(1)

XIV T Cells as Mediators of Bronchial Hyperreactivity

(4)

XV Conclusions

(1)

References

(10)

4 B-Cell Differentiation and IgE Synthesis

(38)

Hamida Hammad

Bart N. Lambrecht

I B-Cell Physiology

(6)

II Immunoglobulin Class Switching

(11)

III Regulation of IgE Synthesis

100

(2)

IV Local IgE Synthesis

102

(1)

V Role of IgE in Asthma

103

(5)

VI Conclusion and Prospects for the Near Future

108

(1)

References

108

(13)

5 Immune Functions of Mast Cells and Basophils

121

(26)

Sarbjit S. Saini

I Introduction

121

(1)

II Origin and Distribution of Mast Cells and Basophils

122

(4)

III IgE Receptor Expression and Cellular Activation

126

(1)

IV Mast Cell and Basophil Mediator Release

127

(1)

V Specific Mediators of Mast Cells and Basophils

128

(3)

VI Cellular Interactions of Mast Cells and Basophils

131

(2)

VII Animal Models of Allergic Airways Disease

133

(1)

VIII Lessons from Therapeutic Studies: Anti-IgE

134

(1)

IX Conclusions

134

(1)

References

135

(12)

6 Immune Functions of Human Eosinophils

147

(42)

Paul J. Coffer

Patricia M.R. e Silva

Marco A. Martins

Leo Koenderman

I Introduction

147

(1)

II Eosinophil Differentiation

148

(7)

III Eosinophil Priming

155

(5)

IV Eosinophil Activation

160

(3)

V Eosinophils in Disease

163

(4)

VI Eosinophils in Allergic Disease

167

(6)

VII Eosinophil-Mediated Inhibitory Mechanisms in Allergic Inflammation

173

(1)

VIII Concluding Remarks

174

(1)

References

174

(15)

7 Immune Functions of Airway Epithelium

189

(32)

Sundeep S. Salvi

Stephen T. Holgate

I Introduction

189

(1)

II Phagocytic Function of Airway Epithelial Cells

189

(1)

III Epithelial Cells as Antigen-Presenting Cells

190

(1)

IV Antimicrobial Activity of Airway Epithelial Cells

190

(3)

V Epithelial Cells as Cellular Sources of Mediator Generation

193

(8)

VI Epithelial Cells as Regulators of Airway Inflammation

201

(2)

VII Anti-Inflammatory Role of Airway Epithelium

203

(1)

VIII Role of Epithelial Cells in Asthma Pathogenesis

204

(3)

IX Role of Epithelial Cells in Airway Remodeling

207

(1)

References

208

(13)

Part Two Regulatory Processes In The Pulmonary Immune Response

8 Tolerance to Inhaled Antigen

221

(22)

Elizabeth R. Jarman

Gerard F. Hoyne

Jonathan R. Lamb

I Asthma: An Inflammatory Response of the Airways to Inhaled Antigen

221

(1)

II Disruption of Immunoregulation and Homeostasis Leads to Induction of Airway Inflammation

222

(1)

III Mucosal Tissues of the Airways and Nasal Cavity

222

(2)

IV In Vivo Models of Mucosal Tolerance

224

(1)

V A Protective Role of IFN-y in Preventing Th2-Mediated Inflammatory Responses

224

(1)

VI Immunoregulatory Role of y6+ T Cells in the Airway Mucosa

225

(1)

VII Induction of Tolerance Following Mucosal Delivery of Antigen: the Role of Immunosuppressive Cytokines TGF-β and IL-10 in Suppressing Inflammatory Responses to Inhaled Antigens

226

(2)

VIII Mechanisms Underlying Induction of Tolerance to Inhaled Antigen

228

(3)

IX Role of Regulatory Cells and Linked Suppression in the Induction of Peripheral Tolerance

231

(2)

X Conclusions

233

(1)

References

234

(9)

9 Sensitization to Inhaled Allergen

243

(18)

Susan L. Prescott

I Introduction

243

(1)

II Immune Responses to Inhaled Allergens and Atopic Inflammation

243

(1)

III Evolution of Allergen-Specific Immune Responses: Before Birth?

244

(1)

IV Implications of Exposure to Antigens/Allergens In Utero

245

(1)

V Maturation of Inhalant Allergen Response in the Postnatal Period

246

(1)

VI Environmental Influences on Immune Development

247

(4)

VII Identifying Children Who Will Ultimately Develop Persistent Inhalant Allergy

251

(1)

VIII Interventions to Reduce Sensitization to Inhalants

251

(2)

IX Conclusions

253

(1)

References

253

(8)

10 Polarization of T-Helper Cells

261

(20)

Martien L. Kapsenberg

Eddy A. Wierenga

Pawel Kalinski

Esther C. De Jong

I Introduction

261

(1)

II Polarized Effector T Cells

262

(2)

III Thl/Th2-Cell-Polarizing Molecules

264

(2)

IV Intracellular Messengers of T-Cell Polarization

266

(2)

V Dendritic Cells

268

(1)

VI Polarized Effector Dendritic Cells

269

(3)

VII Pattern Recognition Molecules

272

(1)

VIII Alternative Pathways of T-Cell Polarization

273

(1)

IX DC and Th2 Cells in Atopy

274

(1)

X Concluding Remarks

275

(1)

References

276

(5)

11 CD28 and B7 Superfamily Members: Costimulation and Regulation of T-Cell Function

281

(12)

Anthony J. Coyle

Stephen Manning

Jose-Carlos Gutierrez-Ramos

I Contemporary Models of T-Cell Activation

281

(1)

II CD28/B7 Costimulatory Pathway

282

(2)

III The Expanding B7 Family

284

(3)

IV Regulation of T-Cell Function by the B7 Family

287

(1)

V Conclusions

288

(1)

References

288

(5)

12 Control of Lymphocyte Trafficking Through the Lung

293

(18)

Reinhard Pabst

Thomas Tschernig

I Introduction

293

(1)

II Heterogeneity of Lymphoctye Subsets

294

(1)

III Techniques for Studying Lymphocyte Traffic to the Lung

295

(1)

IV Lymphocytes in the Lung Are Found in Different Comparments

295

(2)

V Lymphocyte Numbers in the Lung Depend Not Only on Entry from the Blood

297

(1)

VI The Unique Double Blood Supply of the Lung Is of Great Relevance to Lymphocyte Traffic

298

(1)

VII Lack of a Bronchial Blood Supply in the Mouse

298

(1)

VIII Lessons Learned from Neutrophil Migration to the Lung

298

(1)

IX Defensins as Chemoattractants for Lymphoid Cells in the Lung

299

(1)

X Postnatal Increase of Lymphocytes in the BAL Fluid

299

(1)

XI Adhesion Molecules in Lymphocyte Traffic

300

(3)

XII Chemokines in Lymphocyte Traffic to the Lung

303

(1)

XIII Conclusions

304

(1)

References

304

(7)

13 Neuroimmune Interactions in the Pathogenesis of Allergic Asthma

311

(32)

Armin Braun

Wolfgang A. Nockher

Harald Renz

I Cellular Immunity and Airway Inflammation in Allergic Asthma

311

(1)

II Airway Hyperresponsiveness

312

(1)

III Innervation of the Lung

313

(6)

IV Neuronal Changes in Allergic Asthma

319

(3)

V Effects of Inflammatory Mediators on Neurons

322

(1)

VI Putative Role of Neurotrophins in the Pathogenesis of Asthma

323

(3)

VII Effects of Neuropeptides on Immune Cells

326

(3)

VIII Conclusion

329

(1)

References

330

(13)

Part Three Integrated Immunology Of Airway Inflammation

14 Immunopathology of Atopic and Nonatopic Asthma

343

(22)

Marc Humbert

Sun Ying

Douglas S. Robinson

I Introduction

343

(1)

II Eosinophilic Airways Inflammation

344

(2)

III T Lymphocytes

346

(1)

IV B Lymphocytes

347

(5)

V Mast Cells and Basophils

352

(1)

VI Macrophages

352

(1)

VII Cytokines and Chemokines

353

(6)

VIII Conclusion

359

(1)

References

359

(6)

15 Immunology of Eosinophilic Airway Inflammation: What the Animal Models Teach Us

365

(44)

Bart N. Lambrecht

Leonie S. Van Rijt

Harmjan Kuipers

I Human Asthma as a Th2-Driven Disorder?

365

(3)

II Use of Murine Models of Eosinophilic Airway Inflammation

368

(4)

III Role of Antigen-Presenting Cells in the Induction of Airway Eosinophilia in the Mouse

372

(8)

IV Role of Antigen-Presenting Cells in the Maintenance of Airway Eosinophilia in Sensitized Animals

380

(4)

V Role of CD4 Cells and Their Cytokine Products in Inducing Eosinophilic Airway Inflammation and Airway Hyperreactivity

384

(6)

VI Role of CD8 Cells and Their Cytokine Products in Regulating Eosinophilic Airway Inflammation and Airway Hyperreactivity

390

(1)

VII Do Mast Cells and IgE Have an Extended Role Beyond the Early Asthmatic Response by Orchestrating Airway Eosinophilia

391

(1)

VIII Downstream Events That Contribute to the Asthmatic Phenotype in Mice

392

(1)

IX Concluding Remarks

393

(1)

References

393

(16)

16 Regulation of Cellular Traffic in the Asthmatic Lung

409

(30)

Clare M. Lloyd

Jose-Carlos Gutierrez-Ramos

I Introduction

409

(1)

II Inflammatory Infiltrates

409

(1)

III Leukocyte Recruitment

410

(1)

IV The Chemokine Family

410

(2)

V The Chemokine Receptor Family

412

(1)

VI Chemokines in Allergy

413

(4)

VII Evidence for the Functional Roles of Chemokines in Asthma

417

(1)

VIII Migration of Antigen-Specific Effector T Cells

418

(3)

IX Role of Chemokines in the Polarization of the Allergic Response

421

(1)

X Coordination of Chemokine Responses

421

(1)

XI Synergy with Other Inflammatory Mediators

422

(1)

XII Chemotaxis Versus Chemokinesis

423

(1)

XIII Regulation of Chemokine Responses

424

(2)

XIV Chemokines and Their Receptors as Novel Therapeutic Agents

426

(3)

XV Conclusion

429

(1)

References

429

(10)

17 Cytokine Regulation of Bronchial Hyperresponsiveness

439

(28)

Johan C. Kips

Romain A. Pauwels

I Introduction

439

(2)

II Th2-Like Cytokines

441

(8)

III Chemokines

449

(1)

IV Proinflammatory Cytokines

450

(1)

V Immunomodulating Cytokines

451

(3)

VI Conclusion

454

(1)

References

454

(13)

18 Immunological Functions of Inflammatory Mediators

467

(62)

Domenico Spina

Clive Page

Anthony P. Sampson

Zuzana Diamant

I Introduction

467

(1)

II Histamine

468

(2)

III Lipid Mediators

470

(13)

IV Peptide Mediators

483

(10)

V Nitric Oxide

493

(3)

VI Conclusion

496

(1)

References

497

(32)

19 Virally Induced Eosinophilic Airway Inflammation

529

(14)

Wieslawa Olszewska

Peter J.M. Openshaw

I Lung Eosinophilia

529

(1)

II Respiratory Viral Infections

530

(1)

III Vaccine-Enhanced RSV Disease in Humans

531

(1)

IV Animal Models of RSV-Induced Eosinophilia

532

(4)

V Modulating Lung Eosinophilia in Mice

536

(1)

VI Role of Eosinophils in Viral Lung Disease

536

(1)

VII Infection History

537

(1)

VIII Concluding Remarks

538

(1)

References

538

(5)

20 Airway Remodeling as the Outcome of a Chronic Immune Response to Inhaled Allergen

543

(40)

Antonio M. Vignola

Jean Bousquet

I Introduction

543

(1)

II Pathological Characteristics of Airway Remodeling

544

(4)

III Airway Remodeling and Natural History of Asthma

548

(1)

IV Cell Activation by Allergens and Possible Remodeling Effects

549

(12)

V Airway Allergen Challenge Induces Airway Remodeling

561

(3)

VI Longstanding Asthma and Chronic Inflammation Are Likely to Increase Airway Remodeling

564

(1)

VII Conclusions

564

(1)

References

565

(18)

Part Four Immunological Aspects Of Asthma Therapy

21 Immunomodulatory Aspects of Current Asthma Therapy

583

(20)

Peter J. Barnes

I Introduction

583

(1)

II Current Asthma Therapy

583

(2)

III Corticosteroids

585

(7)

IV Theophylline

592

(1)

V Antileukotrienes

593

(1)

VI β-Agonists

594

(1)

VII Steroid-Sparing Therapies

594

(1)

VIII Specific Immunotherapy

595

(1)

IX Future Prospects

595

(1)

References

595

(8)

22 Immunomodulators in the Treatment of Asthma

603

(16)

Martin J. Plummeridge

Anthony J. Frew

I Introduction

603

(1)

II Cyclosporin A

604

(1)

III Antimetabolites

605

(1)

IV Other Immunomodulators

606

(3)

V The Future of Immunomodulators in the Treatment of Asthma

609

(3)

VI T-Cell-Specific Immunosuppressive Drugs

612

(1)

VII Targeting Cellular Recruitment

612

(1)

VIII Antichemokine Strategies

612

(1)

IX Conclusions

612

(1)

References

613

(6)

23 Immunotherapy of Asthma: Prospects for a Vaccine?

619

(24)

Gisela Wohlleben

Klaus J. Erb

I Introduction

619

(2)

II Potential Use of Live or Killed Bacteria as an Asthma Vaccine

621

(2)

III Development of an Asthma Vaccine Using CpG Oligodeoxynucleotides

623

(5)

IV Plasmid DNA Immunization as a Basis for an Efficient Asthma Vaccine

628

(2)

V Additional Approaches Leading to the Discovery of a Potential Asthma Vaccine

630

(3)

VI Conclusions

633

(2)

References

635

(8)

24 Adenovirus-Mediated Gene Therapy for Asthma 643 Ryan E. Wiley, David Alvarez, and Manel Jordana

I Introduction

643

(1)

II Prospects for Adenoviral Gene Therapy

644

(8)

III Inherent Limitations of the Adenoviral Vector

652

(5)

IV Therapeutic Gene Transfer: Targeting the Lung

657

(3)

V Context

660

(4)

References

664

(13)

Author Index

677

(106)

Subject Index

783

Bart N. Lambrecht, Henk C. Hoogsteden, Zuzana Daimant

Püsilink: https://www.kriso.ee/db/9780429150609_pe.html

E-raamat: Immunological Basis of Asthma [Taylor & Francis e-raamat]

Konto & seaded

Otsing

Otsingu andmebaas

Filtreeri tulemusi

Teemad Kirjastuste teemad

Vali ostukorv