Presents papers and discussions from a July 1997 symposium held in London. A number of papers discuss basic mechanisms of tolerance, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Several papers deal with costimulation and tolerance. Consideration is given to clinical applications, with papers on T cell activation in tumor therapy, and tolerance in infectious diseases and during pregnancy. Annotation c. by Book News, Inc., Portland, Or.
The issue of self/non-self discrimination amongst lymphocytes is of vital importance in our understanding of the basic processes of immune recognition. Over the past decades there have been considerable advances in our knowledge of the role of the thymus in "educating" T cells to distinguish self from non-self, and recently there has been a greater appreciation of the importance of immunological tolerance in the periphery during the development of immune responses. Issues as diverse as apoptosis, cell signalling and cell cycle progression, and expression of cytokines have all influenced recent research on the consequences of immunological recognition of foreign antigens. It is clear that the immune system has developed an intricate process for regulating its responses to non-self antigens and, more importantly, self antigens in potential autoimmune settings. This book brings together scientists working on all aspects of immunological tolerance. A number of chapters discuss basic mechanisms of tolerance, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Several chapters deal specifically with costimulation and tolerance. Finally, careful consideration is given to the clinical applications of our understanding of immunological tolerance. Topics discussed include T cell activation during tumour therapy, anti-antigen specific immune suppression, tolerance in infectious diseases, tolerance during pregnancy and tolerance during various autoimmune diseases
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