Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia.
Preface.- The Notch pathway in hematopoietic stem cells.- Notch
receptor-ligand interactions during T cell development, a ligand endocytosis
driven mechanism.- Notch1 and IL-7 receptor signalling in early T-cell
development and leukemia.- Notch signaling during human T cell development.-
Canonical and non-canonical Notch signaling in CD4+T cells.- The role of
Notch in the differentiation of CD4+ T helper cells.- Notch signaling in
alloreactive T cell immunity.- Notch2 and immune function.- Recent advances
on Notch signaling in T-ALL.- Subject code
