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E-raamat: Oxford Textbook of Endocrinology and Diabetes 2nd Revised edition [Oxford Medicine Online e-raamatud]

Edited by (Guy's, King's and St Thomas' School), Edited by (Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Churchill Hospital, Oxford, UK), Edited by , Edited by (Consultant Endocrinologist, Queen Elizabeth Medical Centre, Birmingham, UK)
  • Formaat: 2160 pages, 450 line drawings, 230 halftones, and a 16-page colour plate section
  • Sari: Oxford Textbook
  • Ilmumisaeg: 28-Jul-2011
  • Kirjastus: Oxford University Press
  • ISBN-13: 9780199235292
  • Oxford Medicine Online e-raamatud
  • Raamatu hind pole hetkel teada
  • Formaat: 2160 pages, 450 line drawings, 230 halftones, and a 16-page colour plate section
  • Sari: Oxford Textbook
  • Ilmumisaeg: 28-Jul-2011
  • Kirjastus: Oxford University Press
  • ISBN-13: 9780199235292
Completely revised and updated since publication of the highly-valued first edition in 2002, the Oxford Textbook of Endocrinology and Diabetes second edition provides an up-to-date, stimulating and comprehensive account of endocrinology and diabetes. Containing first rate, pragmatic advice on diagnosis and clear guidelines for recommended management, it also covers the scientific principles that underlie medical practice. Packed into one comprehensive volume, the textbook contains 254 chapters, organised into 13 sections for easy-access to the relevant information. Each chapter is written by an internationally-acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the field. The textbook has an international focus, and where possible deals with medical practice in countries without advanced medical resources. Containing over 700 illustrations, including a colour plate section of 100 full colour photographs, and numerous tables and boxes to complement the text, the textbook is now also available online. Individuals who purchase the print edition of the Oxford Textbook of Endocrinology and Diabetes second edition are entitled to six months free access to the online version.

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Includes 12 months access to the online version

Highly Commended in the Internal Medicine Category, BMA Medical Book Awards 2012
Contributors xv
Abbreviations xxiii
Part 1 Principles of international endocrine practice
1.1 A brief history of endocrinology
3(5)
Robert Arnott
1.2 Prevention in endocrinology
8(6)
Peter Laurberg
Stig Andersen
1.3 Endocrinology and evolution: lessons from comparative endocrinology
14(10)
Janine A. Danks
Samantha J. Richardson
1.4 Hormones and receptors: fundamental considerations
24(5)
John W. Funder
1.5 Molecular aspects of hormonal regulation
29(5)
Shern L. Chew
1.6 Endocrine autoimmunity
34(11)
Matthew J. Simmonds
Stephen C.L. Gough
1.7 Measurement of hormones
45(9)
Mike Wallace
1.8 Endocrine disruptors
54(7)
George Creatsas
George Mastorakos
1.9 Sports endocrinology: the use and abuse of performance-enhancing hormones and drugs
61(10)
Leonard John Deftos
Mark Zeigler
Part 2 Pituitary and hypothalamic diseases
2.1 General concepts of hypothalamus-pituitary anatomy
71(11)
Ignacio Bernabeu
Monica Marazuela
Felipe F. Casanueva
2.2 The neurohypophysis
82(17)
Stephen G. Ball
2.3 Aetiology, pathogenesis, and management of disease of the pituitary
99(134)
2.3.1 Development of the pituitary and genetic forms of hypopituitarism
99(13)
Kyriaki S. Alatzoglou
Mehul T. Dattani
2.3.2 Molecular pathogenesis of pituitary tumours
112(9)
Ines Donangelo
Shlomo Melmed
2.3.3 Histopathology of pituitary tumours
121(6)
Eva Horvath
Kalman Kovacs
2.3.4 Pituitary assessment strategy
127(9)
W.M. Drake
P.J. Trainer
2.3.5 Imaging of the pituitary
136(9)
J.V. Byrne
2.3.6 Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes
145(7)
Trevor A. Howlett
2.3.7 Adult growth hormone deficiency
152(13)
Aurora Aragon-Alonso
Mark Sherlock
Andrew A. Toogood
2.3.8 Surgery of pituitary tumours
165(11)
Ian F. Dunn
Edward R. Laws Jr.
2.3.9 Pituitary radiotherapy
176(11)
Thankamma Ajithkumar
Michael Brada
2.3.10 Prolactinomas and hyperprolactinaemia (including macroprolactinaemia)
187(10)
John S. Bevan
2.3.11 Acromegaly
197(12)
John A.H. Wass
Peter J. Trainer
Marta Korbonits
2.3.12 Clinically nonfunctioning pituitary tumours and gonadotropinomas
209(9)
W.W. de Herder
R.A. Feelders
A.J. van der Lely
2.3.13 Thyrotropinomas
218(5)
Paolo Beck-Peccoz
Luca Persani
2.3.14 Pituitary carcinoma
223(6)
John Ayuk
Christopher J. McCabe
Neil J.L. Gittoes
2.3.15 Pituitary incidentalomas
229(4)
Niki Karavitaki
2.4 Aetiology, pathogenesis, and management of diseases of the hypothalamus
233(34)
2.4.1 Hypothalamic dysfunction (hypothalamic syndromes)
233(7)
M. Guftar Shaikh
2.4.2 Craniopharyngiomas
240(6)
Niki Karavitaki
2.4.3 Perisellar tumours including cysts, hamartomas, and vascular tumours
246(13)
Jurgen Honegger
Rudi Beschorner
Ulrike Ernemann
2.4.4 Lymphocytic hypophysitis and other inflammatory conditions of the pituitary
259(8)
Jelena Kravarusic
Mark E. Molitch
2.5 Pineal physiology and pathophysiology, including pineal tumours
267(6)
Anna Aulinas
Cristina Colom
Susan M. Webb
2.6 Neuropsychiatric endocrinological disorders
273(30)
2.6.1 Endocrinology, sleep and circadian rhythms
273(7)
G. Brabant
2.6.2 Endocrinology of eating disorders
280(7)
Gerasimos E. Krassas
Luigi Bartalena
2.6.3 The endocrine response to stress
287(7)
David E. Henley
Joey M. Kaye
Stafford L. Lightman
2.6.4 Endocrinology and alcohol
294(9)
Margit G. Proescholdt
Marc Walter
Part 3 The thyroid
3.1 Evaluation of the thyroid patient
303(68)
3.1.1 The history and iconography relating to the thyroid gland
303(4)
Robert Volpe
Clark Sawin
3.1.2 Biosynthesis, transport, metabolism, and actions of thyroid hormones
307(14)
Theo J. Visser
3.1.3 Clinical assessment of the thyroid patient
321(4)
Peter Laurberg
Inge Bulow Pedersen
3.1.4 Thyroid function tests and the effects of drugs
325(11)
Jim Stockigt
3.1.5 Nonthyroidal illness
336(9)
R.P. Peeters
3.1.6 Thyroid imaging: nuclear medicine techniques
345(9)
I. Ross McDougall
Andrei Lagaru
3.1.6.1 Thyroid imaging: nonisotopic techniques
354(4)
Laszlo Hegedus
Finn N. Bennedbaek
3.1.7 Epidemiology of thyroid disease and swelling
358(13)
Mark P.J. Vanderpump
3.2 Aetiology of thyroid disorders
371(70)
3.2.1 Genetic factors relating to the thyroid with emphasis on complex diseases
371(14)
Francesca Menconi
Terry F. Davies
Yaron Tomer
3.2.2 Environmental factors
385(11)
Josef Kohrle
3.2.3 Iodine deficiency disorders
396(7)
Michael B. Zimmermann
3.2.4 Disorders of iodine excess
403(5)
Shigenobu Nagataki
Misa Imaizumi
Noboru Takamura
3.2.5 Radiation-induced thyroid disease
408(8)
Furio Pacini
Rossella Elisei
Aldo Pinchera
3.2.6 Autoimmune thyroid disease
416(15)
Anthony P. Weetman
3.2.7 Thyroiditis
431(10)
Beth Kaplan
Elizabeth N. Pearce
Alan P. Farwell
3.3 Thyrotoxicosis and related disorders
441(76)
3.3.1 Clinical assessment and systemic manifestations of thyrotoxicosis
441(11)
Claudio Marcocci
Filomena Cetani
Aldo Pinchera
3.3.2 Thyrotoxic periodic paralysis
452(2)
Annie W.C. Kung
3.3.3 Thyrotoxic storm
454(7)
Joanna Klubo-Gwiezdzinska
Leonard Wartofsky
3.3.4 Subclinical hyperthyroidism
461(5)
Jayne A. Franklyn
3.3.5 Causes and laboratory investigations of thyrotoxicosis
466(10)
Francesco Latrofa
Paolo Vitti
Aldo Pinchera
3.3.6 Antithyroid drug treatment for thyrotoxicosis
476(5)
Anthony Toft
3.3.7 Radio-iodine treatment of hyperthyroidism
481(3)
Markus Luster
Michael Lassmann
3.3.8 Surgery for thyrotoxicosis
484(5)
Mauricio Moreno
Nancy D. Perrier
Orlo Clark
3.3.9 Management of Graves' hyperthyroidism
489(6)
Jacques Orgiazzi
Claire Bournaud
3.3.10 Graves' ophthalmopathy and dermopathy
495(13)
Wilmar M. Wiersinga
3.3.11 Management of toxic multinodular goitre and toxic adenoma
508(3)
Dagmar Fuhrer
John H. Lazarus
3.3.12 Management of thyrotoxicosis without hyperthyroidism
511(6)
Wilmar M. Wiersinga
3.4 Hypothyroidism and pregnancy- and growth-related thyroid disorders
517(69)
3.4.1 Clinical assessment and systemic manifestations of hypothyroidism
517(13)
Massimo Tonacchera
Luca Chiovato
Aldo Pinchera
3.4.2 Causes and laboratory investigation of hypothyroidism
530(7)
Ferruccio Santini
Aldo Pinchera
3.4.3 Myxoedema coma
537(6)
Joanna Klubo-Gwiezdzinska
Leonard Wartofsky
3.4.4 Subclinical hypothyroidism
543(4)
Jayne A. Franklyn
3.4.5 Thyroid disease during pregnancy
547(5)
John H. Lazarus
L.D. Kuvera
E. Premawardhana
3.4.6 Thyroid disease after pregnancy: postpartum thyroiditis
552(5)
Nobuyuki Amino
Sumihisa Kubota
3.4.7 Thyroid disease in newborns, infants, and children
557(14)
A.S. Paul van Trotsenburg
Thomas Vulsma
3.4.8 Thyroid hormone resistance syndrome
571(10)
Mark Gurnell
V. Krishna Chatterjee
3.4.9 Treatment of hypothyroidism
581(5)
Anthony Toft
3.5 Thyroid lumps
586(47)
3.5.1 Pathogenesis of nontoxic goitre
586(3)
Dagmar Fuhrer
3.5.2 Management of nontoxic multinodular goitre
589(6)
Wilmar M. Wiersinga
3.5.3 Management of the single thyroid nodule
595(5)
Laszlo Hegedus
Finn N. Bennedbaek
3.5.4 Pathogenesis of thyroid cancer
600(9)
Dan Mihailescu
Arthur B Schneider
Leon Fogelfeld
3.5.5 Pathology of thyroid cancer
609(6)
Yolanda C. Oertel
3.5.6 Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma
615(10)
Sophie Leboulleux
Martin Jean Schlumberer
3.5.7 Medullary thyroid carcinoma
625(8)
Friedhelm Raue
Karin Frank-Raue
Part 4 Parathyroid, calcium, and bone metabolism
4.1 Parathyroid anatomy, hormone synthesis, secretion, action, and receptors
633(9)
Geoffrey N. Hendy
David Goltzman
4.2 Hypercalcaemia
642(11)
Ronen Levi
Justin Silver
4.3 Primary hyperparathyroidism
653(12)
Shonni J. Silverberg
John P. Bilezikian
4.4 Familial hypocalciuric hypercalcaemia
665(10)
Edward M. Brown
4.5 Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism
675(12)
Rajesh V. Thakker
4.6 Hypercalcaemic and hypocalcaemic syndromes in children
687(14)
Laleh Ardeshirpour
Thomas O. Carpenter
4.7 Osteoporosis
701(11)
Richard Eastell
4.8 Thyroid disorders and bone disease
712(9)
Moira S. Cheung
Apostolos I. Gogakos
J.H. Duncan Bassett
Graham R. Williams
4.9 Paget's disease of bone
721(10)
Socrates E. Papapoulos
4.10 Rickets and osteomalacia (acquired and heritable forms) and skeletal dysplasias
731(23)
Michael P. Whyte
Uri A. Liberman
4.11 Glucocorticoid-induced osteoporosis
754(9)
Gherardo Mazziotti
Andrea Giustina
Ernesto Canalis
John P. Bilezikian
Part 5 The adrenal gland and endocrine hypertension
5.1 Adrenal imaging
763(11)
Peter Guest
5.2 Adrenal surgery
774(7)
Sabapathy P. Balasubramanian
Barney J. Harrison
5.3 Adrenal incidentaloma
781(8)
Massimo Terzolo
5.4 Adrenocortical cancer
789(9)
Rossella Libe
Lionel Groussin
Xavier Bertagna
Jerome Bertherat
5.5 Phaeochromocytomas, paragangliomas, and neuroblastoma
798(12)
Isla S. Mackenzie
Morris J. Brown
5.6 Primary aldosteronism and other steroid-related causes of endocrine hypertension
810(15)
John M.C. Connell
E. Marie Freel
5.7 Cushing's syndrome
825(12)
John Newell-Price
5.8 Glucocorticoid resistance---a defect of the glucocorticoid receptor
837(6)
Elisabeth F.C. van Rossum
Steven W.J. Lamberts
5.9 Adrenal insufficiency
843(17)
Wiebke Arlt
5.10 Familial glucocorticoid deficiency
860(5)
Claire Hughes
Louise Metherell
Adrian J.L. Clark
5.11 Congenital adrenal hyperplasia
865(16)
Nils Krone
Part 6 Neuroendocrine tumours and genetic disorders
6.1 Neuroendocrine tumours of the gastrointestinal tract: an appraisal of the past and perspectives for the future
881(16)
Irvin M Modlin
Bjorn I Gustafsson
Mark Kidd
6.2 Neuroendocrine tumour markers
897(4)
R. Ramachandran
W. Dhillo
6.3 Neuroendocrine (carcinoid) tumours and the carcinoid syndrome
901(7)
Rajaventhan Srirajaskanthan
Martyn E. Caplin
Humphrey Hodgson
6.4 Gastrinoma
908(6)
Christos Toumpanakis
Martyn Caplin
6.5 Insulinoma and hypoglycaemia
914(6)
Puja Mehta
Jeannie F. Todd
6.6 Glucagonoma
920(4)
G.M.K. Nijher
S.R. Bloom
6.7 VIPomas
924(5)
Katie Wynne
6.8 Somatostatinoma
929(3)
John A.H. Wass
6.9 Imaging neuroendocrine tumours of the gastrointestinal tract
932(8)
James E. Jackson
Mary E. Roddie
6.10 Systemic mastocytosis
940(5)
Tomas Ahern
Donal O'Shea
6.11 Multiple endocrine neoplasia type 1
945(6)
R.V. Thakker
6.12 Multiple endocrine neoplasia type 2
951(3)
Niamh M. Martin
Karim Meeran
Stephen R. Bloom
6.13 Von Hippel-Lindau Disease And Succinate Dehydrogenase Subunit (Sdhb, Sdhc, And Sdhd) Genes
954(6)
Eamonn R. Maher
6.14 Neurofibromatosis
960(4)
George Tharakan
6.15 Carney's complex
964(6)
Constantine A. Stratakis
6.16 Molecular and clinical characteristics of the McCune-Albright syndrome
970(10)
Steven A. Lietman
Michael A. Levine
6.17 Cowden's syndrome
980(9)
Charis Eng
Part 7 Growth and development during childhood
7.1 Normal growth and sexual development
989(50)
7.1.1 Child and adolescent growth
989(17)
Gary Butler
7.1.2 Childhood endocrinology
1006(8)
Guy Van Vliet
7.1.3 Sex determination and differentiation
1014(10)
Garry L. Warne
Jacqueline K. Hewitt
7.1.4 Management of differences and disorders of sex development in the newborn
1024(15)
S. Faisal Ahmed
Paula Midgley
Martina Rodie
7.2 Growth and sexual disorders in childhood
1039(98)
7.2.1 Hypoglycaemia: assessment and management
1039(10)
Andrew Cotterill
David Cowley
Ristan Greer
7.2.2 Differential diagnosis of short stature and poor growth velocity
1049(11)
Jesper Johannesen
Christopher T. Cowell
7.2.3 Genetic defects of the human somatotropic axis
1060(5)
Louise A. Metherell
Helen L. Storr
Martin O. Savage
7.2.4 Investigation of the slowly growing child
1065(8)
L. Patel
P.E. Clayton
7.2.5 Growth hormone therapy for the growth hormone-deficient child
1073(10)
Jan M. Wit
Wilma Oostdijk
7.2.6 Growth-promoting agents for nongrowth hormone-deficient short children
1083(12)
Pierre Chatelain
7.2.7 Syndromic growth disorders
1095(12)
Thomas Edouard
Maithe Tauber
7.2.8 Tall stature
1107(5)
Primus E. Mullis
7.2.9 Delayed puberty and hypogonadism
1112(15)
John S. Fuqua
Alan D. Rogol
7.2.10 Premature sexual maturation
1127(10)
Jean-Claude Carel
Juliane Legel
7.3 Congenital adrenal hyperplasia in children
1137(11)
Felix G. Riepe
7.4 Late effects of cancer treatment
1148(12)
Andrew A. Toogood
7.5 Transition in endocrinology
1160(13)
Helena Gleeson
Part 8 Female endocrinology and pregnancy
8.1 Female endocrinology and ovarian disorders
1173(99)
8.1.1 The generation and use of human embryonic stem cells
1173(6)
Mikael C.O. Englund
Christopher L.R. Barratt
8.1.2 Menstrual cycle and ovulation
1179(6)
William L. Ledger
8.1.3 Hormonal contraception
1185(12)
Bliss Kaneshiro
Alison Edelman
8.1.4 Premenstrual syndrome
1197(9)
Andrea Rapkin
Mya Zapata
8.1.5 Primary ovarian failure
1206(6)
Gerard S. Conway
Jacqueline Doyle
Melanie C. Davies
8.1.6 Disorders of gonadotropin secretion
1212(12)
Sarah L. Berga
8.1.7 Hyperprolactinaemic anovulation
1224(5)
Julian R.E. Davis
8.1.8 Polycystic ovary syndrome: reproductive aspects
1229(6)
Sophie Catteau-Jonard
Cecile Gallo
Didier Dewailly
8.1.9 Polycystic ovary syndrome: metabolic aspects
1235(4)
Richard S. Legro
8.1.10 Hirsutism
1239(10)
Bulent O. Yildiz
Ricardo Azziz
8.1.11 Infertility and assisted reproduction
1249(14)
Adam Balen
8.1.12 Nutrition and reproduction
1263(9)
Seiew S. Lim
Robert J. Norman
8.2 Pregnancy-related disorders
1272(61)
8.2.1 The endometrium: receptivity, implantation, and endometrial cancer as endocrine disease
1272(15)
Markku Seppala
Linda C. Giudice
8.2.2 Parturition
1287(11)
Erika F. Werner
Errol R. Norwitz
8.2.3 Gestational trophoblastic neoplasia
1298(7)
Philip Savage
Michael J. Seckl
8.2.4 The breast: lactation and breast cancer as an endocrine disease
1305(13)
R. Santen
8.2.5 Endocrine disease in pregnancy
1318(15)
C. Nelson
S. Germain
Part 9 Male hypogonadism and infertility
9.1 Definitions and classifications of disorders
1333(3)
Eberhard Nieschlag
9.2 Normal male endocrinology
1336(25)
9.2.1 The male gamete: spermatogenesis, mutation, function
1336(11)
C. Marc Luetjens
Gerhard F. Weinbauer
9.2.2 Endocrine and local testicular regulation
1347(6)
Ilpo Huhtaniemi
9.2.3 Testicular hormones
1353(8)
Ilpo Huhtaniemi
9.3 Evaluation of the male patient with suspected hypogonadism and/or infertility
1361(24)
9.3.1 Clinical appearance and examination
1361(2)
Eberhard Nieschlag
9.3.2 Endocrine evaluation
1363(5)
Hermann M. Behre
Eberhard Nieschlag
9.3.3 Semen analysis
1368(5)
Franco Dondero
Andrea Lenzi
Loredana Gandini
9.3.4 Sonography
1373(2)
Hermann M. Behre
Eberhard Nieschlag
9.3.5 Cytogenetics and molecular genetics
1375(5)
Dieter Meschede
Frank Tuttelmann
9.3.6 Testicular biopsy
1380(5)
Wolfgang Schulze
Ulrich A. Knuth
9.4 Male endocrinological disorders and male factor infertility
1385(98)
9.4.1 Congenital anorchia, acquired anorchia, testicular maldescent, varicocele
1385(8)
H.W. Gordon Baker
9.4.2 Disturbed spermatogenesis
1393(5)
Claus Rolf
Eberhard Nieschlag
9.4.3 Klinefelter's syndrome
1398(4)
Dieter Meschede
Eberhard Nieschlag
9.4.4 XX male
1402(1)
Dieter Meschede
Eberhard Nieschlag
9.4.5 XYY male
1403(1)
Dieter Meschede
Eberhard Nieschlag
9.4.6 Structural chromosome abnormalities
1404(4)
Dieter Meschede
9.4.7 Sequelae of extratesticular disease
1408(10)
David J. Handelsman
9.4.8 Testicular tumours
1418(8)
Olof Stahl
Jakob Eberhard
Aleksander Giwercman
9.4.9 Infections/inflammation of the genital tract
1426(2)
Franco Dondero
Francesco Lombardo
9.4.10 Obstructions
1428(1)
Franco Dondero
Francesco Lombardo
9.4.11 Immunology infertility
1429(3)
Franco Dondero
Loredana Gandini
Francesco Lombardo
Andrea Lenzi
9.4.12 Idiopathic infertility
1432(1)
Eberhard Nieschlag
9.4.13 Treatment of hypogonadism and infertility
1432(8)
Eberhard Nieschlag
9.4.14 Insemination, in vitro fertilization, and intracytoplasmic sperm injection
1440(7)
Herman J. Tournaye
9.4.15 Cryopreservation of sperm
1447(2)
A. Kamischke
Eberhard Nieschlag
9.4.16 Sexuality and erectile dysfunction
1449(10)
Cesare Carani
Vincenzo Rochira
Antonio R.M. Granata
9.4.17 Gynaecomastia
1459(4)
Louis J.G. Gooren
9.4.18 Transsexualism
1463(6)
Louis J.G. Gooren
9.4.19 Exogenous factors and male reproductive health
1469(1)
9.5.1 Environmental influences on male reproductive health
1469(6)
Aleksander Giwercman
9.5.2 Androgen misuse and abuse
1475(3)
David J. Handelsman
9.5.3 Male reproductive health
1478(5)
Louis J.G. Gooren
Part 10 Endocrinology of ageing and systemic disease
10.1 Ageing and the endocrine system
1483(52)
10.1.1 Growth hormone and ageing
1483(9)
James Gibney
Ken K.Y. Ho
10.1.2 Endocrinology of the menopause and hormone replacement therapy
1492(11)
Henry G. Burger
Helena J. Teede
10.1.3 Male reproductive health and ageing
1503(8)
David J. Handelsman
10.1.4 Dehydroepiandrosterone and ageing
1511(8)
Wiebke Arlt
10.1.5 Ageing and thyroid disease
1519(7)
Stefano Mariocti
10.1.6 Bone disease in older people
1526(9)
R.L. Prince
10.2 Endocrinology of systemic disease
1535(50)
10.2.1 Hormones and the kidney
1535(11)
Jong Chan Park
Raimund Hirschberg
10.2.2 The endocrinology of liver disease
1546(8)
Alessandro Antonelli
Clodoveo Ferri
Poupak Fallahi
10.2.3 Endocrinology in the critically ill
1554(9)
Hilke Vervenne
Greet Van den Berghe
10.2.4 Endocrine abnormalities in HIV infection
1563(12)
Takara L. Stanley
Steven K. Grinspoon
10.2.5 Immunoendocrinopathy syndromes
1575(10)
W.A. Scherbaum
M. Schott
Part 11 Endocrinology of cancer
11.1 Secondary endocrine tumours, ectopic hormone syndromes, and effects of cancer treatment on endocrine function
1585(26)
11.1.1 Metastatic disease in endocrine organs
1585(5)
Michael Monteiro
David Lowe
11.1.2 Ectopic hormone syndromes
1590(10)
David W. Ray
11.1.3 Long-term endocrine sequelae of cancer therapy
1600(11)
Robert D. Murray
11.2 Hormonal therapy for breast and prostatic cancers
1611(26)
11.2.1 Endocrine treatment of breast cancer
1611(11)
Amna Sheri
Stephen Johnston
11.2.2 Hormonal therapy of prostate cancer
1622(15)
Ciara O'Hanlon Brown
Jonathan Waxman
Part 12 Obesity, lipids, and metabolic disorders
12.1 Epidemiology, aetiology, and management of obesity
1637(22)
12.1.1 Obesity as a health problem
1637(2)
Stefan Rossner
12.1.2 Genetics of obesity
1639(7)
Karine Clement
12.1.3 Assessment and management of severe obesity in childhood and adolescence
1646(3)
Ram Weiss
12.1.4 Assessment and management of severe obesity in adults
1649(3)
I. Sadaf Farooqi
12.1.5 Weight regulation: physiology and pathophysiology
1652(7)
Saira Hameed
Waljit S. Dhillo
12.2 Lipoprotein metabolism and related diseases
1659(18)
12.2.1 Lipoprotein metabolism
1659(8)
Bo Angelin
Paolo Parini
12.2.2 Familial hypercholesterolaemia
1667(6)
Gilbert R. Thompson
12.2.3 Genetic defects in sterol synthesis, absorption, and degradation into bile acids
1673(4)
Stefano Romeo
12.3 Other metabolic disorders
1677(26)
12.3.1 Disorders of carbohydrate metabolism
1677(7)
Robin N. Lachmann
12.3.2 Haemochromatosis
1684(10)
K.J. Allen
12.3.3 The porphyrias
1694(9)
Michael N. Badminton
George H. Elder
Part 13 Diabetes mellitus
13.1 Classification and diagnosis of diabetes mellitus
1703(9)
K. George M.M. Alberti
Paul Zimmet
13.2 Aetiology and pathogenesis of type 1 diabetes mellitus
1712(22)
13.2.1 Clinical features of type 1 diabetes mellitus
1712(7)
Stephanie A. Amiel
13.2.2 Genetics of type 1 diabetes mellitus
1719(4)
David A. Savage
Stephen C. Bain
13.2.3 Immunology of type 1 diabetes mellitus
1723(11)
Mark Peakman
13.3 Aetiology and pathogenesis of type 2 diabetes mellitus
1734(39)
13.3.1 Genetics of type 2 diabetes mellitus
1734(6)
Niels Grarup
Torben Hansen
Oluf Pedersen
13.3.2 Pathophysiology of type 2 diabetes mellitus
1740(8)
Hannele Yki-Jarvinen
13.3.3 Epidemiology of type 2 diabetes mellitus
1748(6)
Sarah Wild
Jackie Price
13.3.4 Monogenic forms of diabetes resulting from β cell dysfunction
1754(5)
Rachel Besser
Andrew Hattersley
13.3.5 Genetics of severe insulin resistance
1759(5)
Robert K. Semple
David B. Savage
Stephen O'Rahilly
13.3.6 Metabolic syndrome
1764(9)
Harold E. Lebovitz
13.4 Management of diabetes mellitus
1773(147)
13.4.1 Clinical features, lifestyle management, and glycaemic targets in type 2 diabetes mellitus
1774(5)
David Matthews
Usha Ayyagari
Pamela Dyson
13.4.2 Pharmacological therapy of hyperglycaemia in type 2 diabetes mellitus
1779(16)
Clifford J. Bailey
Melanie J. Davies
13.4.3 Diabetes in diverse ethnic groups
1795(1)
13.4.3.1 The world pandemic of diabetes
1795(4)
Nigel Unwin
13.4.3.2 Diabetes in South Asians
1799(4)
A. Ramachandran
C. Snehalatha
13.4.3.3 Diabetes in the South Asian diaspora
1803(2)
Srikanth Bellary
Kamlesh Khunti
Anthony H. Barnett
13.4.3.4 Diabetes in sub-Saharan Africa and in Africans
1805(6)
Eugene Sobngwi
13.4.4 Structured education for people with type 2 diabetes mellitus
1811(7)
Simon R. Heller
Marian E. Carey
13.4.5 Metabolic surgery in the treatment of type 2 diabetes mellitus
1818(7)
David E. Cummings
13.4.6 Management of type 1 diabetes mellitus
1825(13)
Simon R. Heller
13.4.7 Type 1 and type 2 diabetes mellitus in children
1838(11)
Krystyna A. Matyka
13.4.8 Hypoglycaemia in the treatment of diabetes mellitus
1849(12)
Pratik Choudhary
Stephanie A. Amiel
13.4.9 Non-biological technologies in glucose sensing
1861(1)
13.4.9.1 Glucose monitoring
1861(8)
John C. Pickup
13.4.9.2 Closing the loop?
1869(5)
Roman Hovorka
13.4.10 Management of diabetes mellitus in special situations
1874(1)
13.4.10.1 Hyperglycaemic crises in adult patients with diabetes mellitus
1874(14)
Abbas E. Kitabchi
Ebenezer Nyenwe
13.4.10.2 Diabetic ketoacidosis in childhood and adoleseence
1888(7)
M. Silink
13.4.10.3 Management of the inpatient with diabetes mellitus
1895(5)
Paul G. McNally
Maggie Sinclair Hammersley
13.4.10.4 Insulin Therapy In The Intensive Care Unit
1900(5)
Greet Van den Berghe
Yoo-Mee Vanwijngaerden
Dieter Mesotten
13.4.10.5 Diabetes management in surgery
1905(3)
Andrew P. Hall
Melanie J. Davies
13.4.10.6 Diabetes management in pregnancy
1908(12)
David R. McCance
13.5 Microvascular complications
1920(35)
13.5.1 Pathogenesis of microvascular disease
1920(4)
Angela Shore
13.5.2 Diabetic retinopathy
1924(11)
Catherine M. Guly
Jane R. MacKinnon
John V. Forrester
13.5.3 Diabetic nephropathy
1935(11)
Janaka Karalliedde
Giancarlo Viberti
13.5.4 Diabetic neuropathy
1946(9)
Solomon Tesfaye
13.6 Macrovascular diseases and diabetes mellitus
1955(21)
13.6.1 Mechanisms of macrovascular disease in diabetes
1955(4)
Peter J. Grant
Mark T. Kearney
13.6.2 Prediction models for cardiovascular disease in diabetes mellitus
1959(4)
Amanda I. Adler
Simon Griffin
13.6.3 Diabetic dyslipidaemia
1963(6)
John Betteridge
13.6.4 Hypertension in diabetes mellitus
1969(7)
Bryan Williams
13.7 The diabetic foot
1976(14)
Michael Edmonds
A.V.M. Foster
13.8 Mental health in diabetes mellitus
1990(15)
13.8.1 Depression in diabetes mellitus
1990(8)
Khalida Ismail
Frank Petrak
13.8.2 Diabetes mellitus and psychotic disease
1998(7)
John W. Newcomer
13.9 Organization of diabetes care
2005(10)
13.9.1 Organizing a diabetes service
2005(6)
Stephen C.L. Gough
13.9.2 The informatics of diabetes management
2011(4)
John P. New
Jain E. Buchan
13.10 Transplantation in Diabetes
2015(9)
13.10.1 Treatment of diabetes (Type I) through transplantation
2015(4)
Parthi Srinivasan
13.10.2 Diabetes mellitus and transplantation
2019(5)
Paul Riley
John O'Grady
13.11 Gene therapy in diabetes mellitus
2024(7)
James A.M. Shaw
Kevin Docherty
Index 2031