Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption supplies new studies on the role of the skin as a key portal of entry for chemicals into the body this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.
Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.
Key Features:
- Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption
- Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery
- Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
1 Molecular structure and function of the skin barrier 2 Mathematical
Models in Percutaneous Absorption 3 In Vivo Percutaneous Absorption: A Key
Role for Stratum Corneum/ Vehicle Partitioning 4 The Skin Reservoir for
Topically Applied Solutes 5 Chemical Partitioning into Powdered Human Stratum
Corneum: A Useful In Vitro Model for Studying Interaction of Chemicals and
Human Skin 6 Variations of Hair Follicle Size and Distribution in Different
Body Sites 7 In Vivo Relationship Between Percutaneous Absorption and
Transepidermal Water Loss 8 The correlation between transepidermal water loss
and percutaneous absorption: An updated overview 9 Human Percutaneous
Absorption and Transepidermal Water Loss (TEWL) Correlation 10 Evaluation of
Stratum Corneum Heterogeneity 11 Regional Variation in Percutaneous
Absorption: Principles and Applications to Human Risk Assessment 12 Effects
of Anatomical Location on In Vivo Percutaneous Penetration in Man 13
Interrelationships in the Dose-Response of Percutaneous Absorption 14 Effects
of Occlusion: Percutaneous Absorption 15 Occlusion Does Not Uniformly Enhance
Penetration In Vivo 16 Effect of Single vs. Multiple Dosing in Percutaneous
Absorption 17 Influence of formulation on topical and transdermal drug
delivery 18 In Vitro Release from Semisolid Dosage FormsWhat Is Its Value?
19 Understanding Skin Metabolism: Effect on Altering In Vitro Skin Absorption
and Bioavailability of Topically Applied Chemicals 20 Phenomenon of Lateral
Spread in Percutaneous Penetration 21 Clinically Pertinent
Factors/Observations Affecting Percutaneous Absorption in Humans 22
Percutaneous Absorption of Chemical Mixtures 23 Dermal Decontamination and
Percutaneous Absorption 24 Skin Decontaminartion 25 Chemical Warfare Agent VX
Penetration Through Military Uniform and Human Skin: Risk Assessment and
Decontamination 26 Percutaneous Absorption of Hazardous Chemicals from Fabric
into and Through Human Skin 27 Percutaneous Absorption of Chemicals from
Fabric (Textile) 28 The Fate of Material Remaining in Skin in In Vitro
Absorption Studies 29 Skin Absorption of Hair Dyes 30 Hair Dye Penetration in
Monkey and Man 31 Percutaneous Absorption of Sunscreens 32 Sunscreen
Percutaneous Penetration in Vivo in Man 33 Cutaneous Metabolism of
Xenobiotics 34 Chemical modification: an important and feasible method for
improving peptide and protein dermal and transdermal delivery 35 Enchancing
Percutaneous Penetration of Oligonucleotide Drugs 36 Use of Microemulsions
for Topical Drug Delivery 37 Transdermal Delivery of Vesicular Nanocarriers
Under Electrical Potential 38 Nanocarriers and physical methods 39 Assessment
of Microneedles for Transdermal Drug Delivery 40 Clinical Testing of
Microneedles for Transdermal Drug Delivery 41 Delivery of drugs, vaccines,
and cosmeceuticals to skin using microneedle patches 42 Mirconeedle
dermatotoxicology 43 Transdermal Transport by sonophoresis 44 Effect of Tape
Stripping on Percutaneous Penetration and Topical Vaccination 45
Transcutaneous Delivery of Drugs by Electroporation 46 IONTOPHORESIS IN
PENETRATION ENHANCEMENT 47 VEHICLES AND TOPICAL THERAPY 48 The role of in
vitro skin models in optimization of dermal drug delivery 49 Effects of
phospholipids on skin: use of primary human keratinocytes and fibroblasts as
2D cell culture models 50 Human cadaver skin viability for in vitro
percutaneous absorption: storage and detrimental effects 51 Determination of
Percutaneous Absorption by In Vitro Techniques 52 Stripping Method for
Measuring Percutaneous Absorption In Vivo 53 Tape Stripping - Technique and
Applications 54 Blood flow as technology in percutaneous absorption 55
Confocal Raman Microspectroscopy in the assessment of skin barrier function
and drug penetration 56 Microscopy methods for assessing percutaneous drug
penetration 57 Dermal sampling techniques with focus on dermal Open Flow
Microperfusion 58 Dermal-epidermal Separation Methods: Research Implications
59 Use of Skin Absorption Data in the Safety Evaluation of Cosmetic
Ingredients 60 Bioequivalence, Pharmaceutical Equivalence, and Biowaivers:
Topical Dosage Forms for Local Action 61 In Vitro Human Nail Model To
Evaluate Ungual Absorption and Transungual Delivery 62 Drug Permeation
through Burn Eschar: Possibilities and Improvements 63 Percutaneous
Penetration in Humans: Transfer of Chemicals via Skin-to-Skin Contact 64
Nanoparticles and Their Combination with Physical Methods for Dermal and
Transdermal Drug Delivery
Dr. Nina Dragievi is a professor in Pharmaceutical technology at the Department of Pharmacy at the Singidunum University in Belgrade, Serbia. She earned her masters degree at the University of Belgrade, Faculty of Pharmacy, in 1999 and subsequently earned a Magister Degree and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical technology from the University of Belgrade and the Friedrich-Schiller University Jena, Germany, respectively. Before her employment at the University Singidunum, Dr. Dragievi worked as an accredited specialist in Pharmaceutical technology in the state pharmaceutical chain Apoteka "Beograd" in Belgrade. From 2007 to 2013 she was responsible for the preparation of compounded drugs for different routes of administration in pharmacies of Apoteka "Beograd", and in 2013 she was appointed director of the Production Department in the same company. She has published in a variety of international journals and she is editor of six books.
Professor Howard I. Maibach, Ph.D. is currently serving as Professor of Dermatology at the University of California, San Francisco. He earned his MD from Tulane University, New Orleans, LA in 1955. Later he served in faculty positions in various levels at the UCSF. Dr. Maibach has over 2,520 published manuscripts. He has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health.
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