This book rigorously establishes some key aspects of Raman basic science in the biomedical field and discusses the physics governing its application to both synthetic and natural biomaterials by disentangling spectrally convoluted dependencies on crystal orientation, chemical and stoichiometric alterations, and mechanical stress.
Raman spectroscopy has enormous potential in the field of biomaterials science for both basic and applied research. However, its application in biomedical sciences is yet in its infancy because Raman physics currently lacks effective working algorithms, mainly due to its complexity. Raman algorithm exploitations will improve preventive care, effective disease diagnosis, and new curative therapies, while reducing healthcare expenditures. Raman methods encompass a number of technologies for quantitative assessments of crystal structures, domain textures, crystallographic alignments, off-stoichiometric chemical drifts, and mechanical stresses in both synthetic and natural biomaterials; each of those governs the fundamental interactions of both biotic and abiotic materials within the human host. This book rigorously establishes key aspects of Raman science in the biomedical field and discusses the physics governing its application to both synthetic and natural biomaterials by disentangling spectrally convoluted dependencies on crystal orientation, chemical and stoichiometric alterations, and mechanical stress.
1. Introduction
2. Theoretical Foundations and State of the Art in Raman
Spectroscopy
3. Raman Probe, Spectroscopic Equipment and Software
4. Raman
Selection Rules and their Experimental Verification
5. Secular Equations and
their Experimental Verification
6. Orientation Distribution Functions for
Statistical Analyses in the Probe Volume
7. Conclusions and Future
Perspectives Appendix: Short Tutorial on Group Theory and Space Groups in
Real and Reciprocal Spaces
Giuseppe Pezzotti is distinguished professor and director of the Biomedical Engineering Center of Kansai Medical University in Osaka, Japan. Before this appointment, he was a full professor at the Ceramic Physics Laboratory of Kyoto Institute of Technology, where he was also vice president for International Affairs and Collaborative Research in Health Science for 7 years and is now an emeritus professor. Prof. Pezzotti holds 6 doctoral degrees in different scientific fields, has published more than 800 scientific papers, has authored 3 books, and holds patents in various disciplines, including a world patent on nanoscale stress microscopy, for which he was awarded the prestigious Prize for Scientific Research of the Ministry of Education of Japan in 2017.
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