A pioneer in performing pulmonary allographs in the 1960s introduces this text as a comprehensive guide to developments in clinical applications involving donated tissues or cells (including stem cells). Fehily (National Transplant Centre, Rome) and other specialists working with tissue and blood banks worldwide treat techniques to preserve and process donated tissues and cells of various kinds. In historical and global contexts, they discuss regulations; risk management; principles/phases from cell and tissue collection to decontamination; biocompatibility testing for transplantation; coding for therapeutic products; and training of tissue bank personnel. Chapters include case studies with lessons learned, preservation methodologies, discussions of recovery and processing related issues and future R&D efforts, illustrations, further reading, and a color plate gallery. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com)
By presenting the latest technological advances and growing national and international regulation, this new book explores state-of-the-art developments in the challenging field of tissue and cell processing. It provides a guide to easier and safer practice in operational principles of preservation, decontamination, and sterilization. Nearly half of the book is devoted completely to tissue- or cell-specific issues relating to processing. With lists of learning points and case studies which consist of sample processing protocols, descriptions of where processing went wrong, sample risk assessments, or validation studies, the authors help you find specific information fast.
| Contributors |
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vii | |
| Foreword |
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xii | |
| Preface |
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xiii | |
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1 Regulations and Standards |
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1 | (20) |
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2 Risk Management in Tissue and Cell Processing |
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21 | (23) |
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3 Principles of Cell Collection and Tissue Recovery |
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44 | (27) |
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4 Principles of Cell and Tissue Cryopreservation |
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71 | (14) |
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5 Principles of Tissue Decontamination and Sterilization |
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85 | (20) |
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6 Control of Contamination and Cross-contamination During Processing: Optimizing the Processing Environment |
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105 | (19) |
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7 The Principles of Process Validation and Equipment Qualification |
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124 | (24) |
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8 Biomechanical and Biocompatibility Testing Considerations |
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148 | (13) |
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9 Coding and Traceability |
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161 | (19) |
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Izabela Uhrynowska-Tyszkiewicz |
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10 Training of Tissue Bank Personnel |
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180 | (17) |
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11 Cardiac Tissue: Specific Recovery and Processing Issues |
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197 | (20) |
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12 Skin: Specific Recovery and Processing Issues |
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217 | (12) |
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13 Ophthalmic Tissues: Specific Recovery and Processing Issues |
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229 | (23) |
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14 Skeletal Tissue: Specific Recovery and Processing Issues |
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252 | (19) |
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15 Processing of Cells for Transplantation |
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271 | (22) |
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16 Gametes and Embryos: Specific Collection and Processing Issues |
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293 | (17) |
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17 Engineering of Human Tissue Grafts |
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310 | (17) |
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| Index |
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327 | |
Deirdre Fehily PhD Inspector and Technical Advisor, Tissues and Cells, National Transplant Centre, Rome, Italy Scott A. Brubaker CTBS Chief Policy Officer, American Association of Tissue Banks, McLean, Virginia, USA John N. Kearney BSc, PhD, CBiol, MIBiol, SRCS Head of Tissue Services/Lead Scientist/PI for Research, Liverpool Blood Centre, NHS Blood & Transplant, Liverpool, UK Lloyd Wolfinbarger Jr. PhD BioScience Consultants, llc, Norfolk, Virginia, USA