The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapters on the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecular neurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods, are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Introduction
1. Electrical Activity of the Nerve: The Background up to 1952, Sir A. Huxley
The Normal Axon
2. Morphology of Normal Peripheral Axons, C-H. Berthold and M. Rydmark
3. Morphology of Central Nervous System Axons, A. Hirano and J.F. Llena
4. Physiology of Axons, J.M. Ritchie
5. The Schwann Cell: Morphology and Development, N. Kleitman and R.P. Bunge
6. The Oligodendrocyte, The Perinodal Astrocyte, and the Central Node of Ranvier, J.A. Black, H.W. Sontheimer, and S.G. Waxman
7. Molecular Biology of Myelination, E.S. Monuki and G.E. Lemke
8. Mechanisms of Adhesion Between Axons and Glial Cells, J.L. Salzer
9. Axonal Transport: Function and Mechanisms, B. Grafstein
10. Development of Axons: Calcium, Steering and the Growth Cone, R.W. Davenport, S. Bolsover, and S.B. Kater
11. Voltaged-gated Ion Channels in Axons: Localization, Function, and Development, S.G. Waxman
12. Molecular Biology of Voltage-dependent Potassium and Sodium Channels, R.L. Barchi
13. Voltage-clamp Studies in Axons: Macroscopic and Single Channel Currents, W. Vogel and J.R. Schwartz
14. Modulation of Axonal Excitability by Neurotransmitter Receptors, J.D. Kocsis and K. Sakatani
15. Ion Pumps and Exchangers, P.K. Stys, S.G. Waxman, and B.R. Ransom
16. Mechanisms of Accommodation and adaptation in Myelinated Axons, H. Bostock
17. Electrophysiological Approaches to the Study of Axons, P.K. Stys and J.D. Kocsis
18. Action Potential Conduction Recorded Optically in Normal, Demyelinated and Remyelinating Axons, P. Shrager
Principles of Axonal Pathophysiology
19. Reactiono of the Neuronal Cell Body to Axonal Damage, G.W. Kreutzberg
20. Axonal Degeneration and Disorders of the Axonal Cytoskeleton, J.W. Griffin, et al.
21. Pathology of Demyelinated and Dysmyelinated Axons, J. Rosenbluth
22. Pathology of the Myelin Sheath, S.K. Ludwin
23. Pathophysiology of Demyelinated Axons, S.G. Waxman, J.D. Kocsis, and J.A. Black
24. Anoxic-ischemic Injury in Axons, P.K. Stys, et al.
25. Traumatic Injury of Spinal Axons, O. Honmou and W. Young
26. Diffuse Axonal Injury, J.T. Povlshock and C.W. Christman
27. Abnormal Excitability in Injured Axons, M. Devor
28. Regeneration of PNS Axons, M.A. Bisby
29. Role of Cellular Interactions in Axonal Growth and Regeneration, L. McKerracher, J.P. Julien, and A.J. Aguayo
30. Clinical Electrophysiology of PNS Axons, J. Kimura
31. Clinical Assessment of CNS Axons: Evoked Potentials, S.J. Jones
32. Human Peripheral Nerve Disease (Peripheral Neuropathies, A.R. Berger and H.H. Schaumburg
33. Overview of Clinical Aspects of Multiple Sclerosis, Including Cognitive Deficit, W.I. McDonald
34. Clinical Aspects of Traumatic Injury to CNS Axons, M.R. Dimitrijevic
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