The axon, interposed between the cell body and the synaptic terminals in most neurons, plays a crucial role in connecting neurons and acting as a conduit for the transmission of information between them. This book provides a comprehensive and up-to-date compendium that brings together chapters on the structure, function, and pathophysiology of axons in both the PNS and CNS. Carefully written, well-illustrated with superb illustrations, and generously referenced, the 33 chapters and introduction have been authored by 49 world-renowned authorities. Recent advances in the molecular neurobiology of axons are carefully reviewed, and new areas, such as the molecular biology of ion channels and myelination, the role of calcium in pathophysiology and regeneration, cell adhesion molecules and their roles in axo-glial interactions and axonal guidance, and optical recording methods, are highlighted. This book will provide an essential reference for neuroscientists as well as clinicians such as neurologists, neurosurgeons, and clinical electrophysiologists interested in axons.
Arvustused
"A very nice compendium of current information about axonal histological structure, physiology and pathophysiology. There is an 'all star' cast of authors."--Canadian Journal of Neurological Sciences "The Axon: Structure, Function and Pathophysiology is an excellent addition to the field of axon physiology and pathophysiology. The book is well written and topics are thoroughly covered in a fashion suitable for both basic and clinical neuroscientists. The high-quality illustrations and photomicrographs and the succinct figure legends make it easy for readers to find and understand key points this book should become an important reference for people seeking a better understanding of axon biology."--New England Journal of Medicine "The illustrations are outstanding....The photomicrographs of nerves are the best that I have seen....The chapters are heavily referenced, with almost all having citations of articles from 1994 and even, in a chapter or two, 1995. This is unusual and remarkable. The authors have produced an encyclopedic reference book with material that is almost as up-to-date as a journal article....Waxman, Kocsis and Stys have edited an excellent reference volume that is up-to-date and extremely well illustrated. This is the sort of book that should be a standard in neurology and neurosurgery department libraries regardless of academic orientation. For departments of ophthamology and otolaryngology, this book is also a must."--Journal of the American Medical Association Noted, not reviewed, in Doody's Journal "An impressive book....with elegant descriptions....There are many stunning freeze-fracture and electron micrographs....The breadth of this book will improve knowledge about the axon for both basic and clinical scientists.This is to be welcomed."--Trends in Neurosciences
Introduction
1. Electrical Activity of the Nerve: The Background up to 1952, Sir A. Huxley
The Normal Axon
2. Morphology of Normal Peripheral Axons, C-H. Berthold and M. Rydmark
3. Morphology of Central Nervous System Axons, A. Hirano and J.F. Llena
4. Physiology of Axons, J.M. Ritchie
5. The Schwann Cell: Morphology and Development, N. Kleitman and R.P. Bunge
6. The Oligodendrocyte, The Perinodal Astrocyte, and the Central Node of Ranvier, J.A. Black, H.W. Sontheimer, and S.G. Waxman
7. Molecular Biology of Myelination, E.S. Monuki and G.E. Lemke
8. Mechanisms of Adhesion Between Axons and Glial Cells, J.L. Salzer
9. Axonal Transport: Function and Mechanisms, B. Grafstein
10. Development of Axons: Calcium, Steering and the Growth Cone, R.W. Davenport, S. Bolsover, and S.B. Kater
11. Voltaged-gated Ion Channels in Axons: Localization, Function, and Development, S.G. Waxman
12. Molecular Biology of Voltage-dependent Potassium and Sodium Channels, R.L. Barchi
13. Voltage-clamp Studies in Axons: Macroscopic and Single Channel Currents, W. Vogel and J.R. Schwartz
14. Modulation of Axonal Excitability by Neurotransmitter Receptors, J.D. Kocsis and K. Sakatani
15. Ion Pumps and Exchangers, P.K. Stys, S.G. Waxman, and B.R. Ransom
16. Mechanisms of Accommodation and adaptation in Myelinated Axons, H. Bostock
17. Electrophysiological Approaches to the Study of Axons, P.K. Stys and J.D. Kocsis
18. Action Potential Conduction Recorded Optically in Normal, Demyelinated and Remyelinating Axons, P. Shrager
Principles of Axonal Pathophysiology
19. Reactiono of the Neuronal Cell Body to Axonal Damage, G.W. Kreutzberg
20. Axonal Degeneration and Disorders of the Axonal Cytoskeleton, J.W. Griffin, et al.
21. Pathology of Demyelinated and Dysmyelinated Axons, J. Rosenbluth
22. Pathology of the Myelin Sheath, S.K. Ludwin
23. Pathophysiology of Demyelinated Axons, S.G. Waxman, J.D. Kocsis, and J.A. Black
24. Anoxic-ischemic Injury in Axons, P.K. Stys, et al.
25. Traumatic Injury of Spinal Axons, O. Honmou and W. Young
26. Diffuse Axonal Injury, J.T. Povlshock and C.W. Christman
27. Abnormal Excitability in Injured Axons, M. Devor
28. Regeneration of PNS Axons, M.A. Bisby
29. Role of Cellular Interactions in Axonal Growth and Regeneration, L. McKerracher, J.P. Julien, and A.J. Aguayo
30. Clinical Electrophysiology of PNS Axons, J. Kimura
31. Clinical Assessment of CNS Axons: Evoked Potentials, S.J. Jones
32. Human Peripheral Nerve Disease (Peripheral Neuropathies, A.R. Berger and H.H. Schaumburg
33. Overview of Clinical Aspects of Multiple Sclerosis, Including Cognitive Deficit, W.I. McDonald
34. Clinical Aspects of Traumatic Injury to CNS Axons, M.R. Dimitrijevic
