| Preface |
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xix | |
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xxii | |
| Acknowledgement |
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1 | (20) |
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1.1 Coffee---a popular beverage |
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1 | (1) |
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1.2 Coffee from a nutritional perspective |
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1 | (1) |
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1.3 Potential beneficial effects of coffee |
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2 | (1) |
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1.4 Limitations to the beneficial effects |
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3 | (2) |
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5 | (1) |
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1.6 Coffee production worldwide |
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5 | (1) |
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1.7 Coffee processing: formation and fate of bioactive compounds |
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5 | (5) |
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1.7.1 Green bean processing, storage, and transport |
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6 | (2) |
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8 | (1) |
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8 | (2) |
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10 | (1) |
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1.7.5 Packaging and storage |
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10 | (1) |
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10 | (1) |
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1.7.7 Soluble coffee production |
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10 | (1) |
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1.8 New processes to optimize the health benefits of coffee |
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1.8.1 Enhancement with mannooligosaccharides |
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11 | (1) |
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1.8.2 Use of green bean extracts |
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11 | (1) |
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1.8.3 After-roast blending for enhanced antioxidative properties |
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11 | (1) |
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1.8.4 Stomach-friendly coffee |
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12 | (1) |
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12 | (2) |
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13 | (1) |
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1.9.2 Cafetiere or French press coffee |
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13 | (1) |
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13 | (1) |
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13 | (1) |
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13 | (1) |
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13 | (1) |
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13 | (1) |
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1.9.9 Single-serve coffee machines |
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14 | (1) |
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1.10 Coffee beverages and specialties |
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14 | (1) |
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14 | (2) |
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16 | (5) |
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16 | (1) |
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17 | (4) |
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21 | (38) |
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21 | (1) |
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2.2 Production of coffee and coffee-based beverages |
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22 | (4) |
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2.2.1 Green coffee production |
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22 | (1) |
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2.2.2 Decaffeinated coffee production |
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23 | (1) |
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2.2.3 Steam-treated and monsooned coffees |
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24 | (1) |
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24 | (1) |
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25 | (1) |
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2.2.6 Instant coffee production |
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26 | (1) |
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2.3 Natural coffee constituents |
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26 | (17) |
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2.3.1 Green coffee chemical composition |
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27 | (1) |
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2.3.1.1 Nonvolatile compounds in green coffee |
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27 | (1) |
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28 | (1) |
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29 | (1) |
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30 | (1) |
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31 | (1) |
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32 | (1) |
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33 | (1) |
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33 | (1) |
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Protein, peptides, and free amino acids |
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33 | (1) |
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33 | (1) |
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34 | (1) |
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2.3.1.2 Volatile compounds in green coffee |
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34 | (1) |
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2.3.2 Changes in coffee chemical composition during roasting |
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35 | (1) |
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2.3.2.1 Nonvolatile components in roasted coffee |
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35 | (2) |
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2.3.2.2 Volatile compounds in roasted coffee |
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37 | (2) |
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2.3.3 Changes in coffee chemical composition during special coffee processing |
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39 | (2) |
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2.3.4 Chemical composition of coffee brew |
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41 | (2) |
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2.4 Incidental coffee constituents |
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43 | (7) |
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2.4.1 Incidental nonvolatile compounds in coffee |
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43 | (1) |
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43 | (1) |
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44 | (1) |
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45 | (1) |
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46 | (1) |
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2.4.1.5 Polycyclic aromatic hydrocarbons |
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47 | (1) |
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2.4.1.6 Pesticide residues |
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48 | (1) |
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2.4.2 Incidental volatile constituents in coffee |
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48 | (2) |
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50 | (9) |
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50 | (1) |
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50 | (9) |
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3 Bioavailability of Coffee Chlorogenic Acids |
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59 | (18) |
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59 | (1) |
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3.2 Chlorogenic acids: contribution of coffee to dietary levels ingested |
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59 | (3) |
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59 | (2) |
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3.2.2 Levels in coffee beverage |
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61 | (1) |
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3.3 Bioavailability of coffee chlorogenic acids |
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62 | (10) |
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3.3.1 Absorption and metabolic fate |
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62 | (1) |
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3.3.2 Extensive metabolism upon intake |
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62 | (1) |
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3.3.2.1 Identification of chlorogenic acid metabolites |
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62 | (1) |
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3.3.2.2 Metabolic pathways |
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62 | (6) |
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3.3.2.3 Bioavailability of intact chlorogenic acids |
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68 | (3) |
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3.3.3 Urinary and biliary excretion |
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71 | (1) |
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3.3.4 Effects of food matrix and co-ingestion on bioavailability |
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71 | (1) |
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72 | (5) |
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73 | (4) |
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4 Coffee and Alzheimer's Disease: Animal and Cellular Evidence |
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77 | (20) |
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77 | (1) |
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77 | (4) |
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77 | (1) |
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78 | (1) |
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78 | (1) |
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78 | (1) |
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4.2.5 Cerebral amyloidosis |
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78 | (1) |
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4.2.6 Other neuropathology |
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79 | (1) |
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79 | (1) |
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80 | (1) |
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80 | (1) |
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4.2.10 Cellular and animal models of Alzheimer's disease |
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80 | (1) |
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81 | (1) |
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81 | (1) |
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82 | (1) |
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82 | (4) |
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83 | (1) |
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83 | (3) |
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86 | (3) |
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86 | (1) |
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87 | (1) |
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88 | (1) |
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4.5.4 Dicinnamoylquinides |
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89 | (1) |
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4.6 Other coffee constituents |
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89 | (2) |
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89 | (1) |
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4.6.2 Kahweol and cafestol |
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90 | (1) |
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91 | (1) |
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91 | (6) |
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92 | (5) |
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5 Coffee and Alzheimer's Disease---Epidemiologic Evidence |
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97 | (14) |
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97 | (1) |
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5.2 Review of epidemiologic studies of coffee in relation to Alzheimer's disease, dementia, and selected aspects of cognitive functioning |
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98 | (8) |
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5.2.1 Case-control/retrospective studies |
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98 | (1) |
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5.2.2 Cross-sectional studies |
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99 | (1) |
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5.2.3 Prospective cohort studies |
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100 | (6) |
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5.3 The strength of the evidence for preventing Alzheimer's disease |
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106 | (5) |
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108 | (3) |
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6 Coffee and Parkinson's Disease |
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111 | (12) |
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111 | (1) |
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6.2 Pathogenesis of Parkinson's disease |
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111 | (1) |
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6.3 Gene and environmental/lifestyle factors |
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112 | (1) |
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6.4 Clinical evidence linking coffee consumption and Parkinson's disease |
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113 | (2) |
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6.5 Neuroprotection and active components of coffee |
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115 | (1) |
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6.6 Adenosine receptor antagonism and Parkinson's disease |
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116 | (1) |
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6.7 Caffeine rescue of Parkinson's disease in animal models |
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116 | (1) |
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6.8 Clinical trials of adenosine receptor antagonists in Parkinson's disease |
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117 | (1) |
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6.9 Caffeine-mediated genetic susceptibility of Parkinson's disease |
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118 | (1) |
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118 | (5) |
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119 | (1) |
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119 | (4) |
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7 Coffee and Liver Health |
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123 | (18) |
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123 | (1) |
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7.2 Epidemiologic studies |
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124 | (1) |
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7.2.1 Coffee and liver enzymes |
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124 | (1) |
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7.3 Coffee, fibrosis, and cirrhosis |
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124 | (2) |
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7.3.1 General aspects of fibrosis and cirrhosis |
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124 | (1) |
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7.3.2 Coffee and cirrhosis |
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125 | (1) |
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7.4 Coffee and animal models of hepatic fibrosis |
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126 | (1) |
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7.5 Cytokines and liver fibrosis |
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127 | (1) |
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7.5.1 Transforming growth factor-β in liver fibrogenesis |
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128 | (1) |
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7.6 Mechanism of coffee's protective effect |
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128 | (4) |
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7.6.1 Oxidative stress, antioxidant-dependent mechanisms |
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128 | (2) |
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7.6.2 Chemoprotective mechanisms: cafestol and kahweol |
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130 | (1) |
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7.6.3 Phase I-mediated mechanisms |
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130 | (1) |
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7.6.4 Inhibition of phase I activating enzyme expression |
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130 | (1) |
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7.6.5 Inhibition of phase I enzymatic activity |
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131 | (1) |
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7.6.6 Induction of phase II detoxifying enzymes |
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131 | (1) |
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7.6.7 Molecular mechanism of induction: Nrf2/ARE signal pathway |
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132 | (1) |
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7.7 Adenosine A2A receptors and caffeine |
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132 | (2) |
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7.7.1 Proinflammatory and anti-inflammatory actions of caffeine mediated through the adenosine A2A receptor |
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132 | (2) |
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7.8 Caffeine metabolism and drug interactions |
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134 | (1) |
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134 | (7) |
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135 | (6) |
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8 Coffee and Type 2 Diabetes Risk |
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141 | (40) |
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141 | (1) |
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8.2 Observational associations between coffee consumption and type diabetes risk |
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142 | (12) |
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154 | (2) |
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8.3.1 Type of coffee: ground or instant |
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154 | (1) |
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8.3.2 Addition of milk or sugar |
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155 | (1) |
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8.3.3 Caffeine and noncaffeine components of coffee |
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155 | (1) |
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8.3.4 Lifestyle-related factors |
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156 | (1) |
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8.4 Observational associations between coffee consumption and diabetes risk factors |
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156 | (3) |
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8.5 Intervention studies in human subjects |
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159 | (7) |
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8.5.1 Effects of caffeine on glucose tolerance |
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159 | (1) |
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8.5.2 Effects of caffeinated coffee on glucose tolerance |
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160 | (4) |
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8.5.3 Effects of noncaffeine coffee components on glucose tolerance |
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164 | (1) |
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8.5.4 Effects of coffee consumption on other diabetes risk factors |
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165 | (1) |
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8.5.5 Limitations of the existing intervention literature on coffee and diabetes |
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165 | (1) |
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8.6 Possible mechanisms of action |
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166 | (4) |
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8.6.1 Modulation of energy expenditure by caffeine |
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167 | (1) |
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8.6.2 Modulation of carbohydrate absorption and incretin response |
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167 | (1) |
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8.6.3 Modulation of hepatic glucose output |
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167 | (1) |
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8.6.4 Modulation of insulin sensitivity |
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168 | (1) |
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8.6.4.1 Anti-inflammatory effects |
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168 | (1) |
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8.6.4.2 Antioxidative effects |
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169 | (1) |
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8.6.4.3 Estrogen receptor activation |
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169 | (1) |
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8.6.4.4 Inhibition of 11β-hydroxysteroid dehydrogenase |
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169 | (1) |
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8.6.4.5 Iron and magnesium status |
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170 | (1) |
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8.7 Summary and conclusions |
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170 | (11) |
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171 | (10) |
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9 Coffee and Cardiovascular Diseases |
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181 | (16) |
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181 | (1) |
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9.2 Coffee components and CVD |
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181 | (2) |
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182 | (1) |
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9.2.2 Diterpenes: kahweol & cafestol |
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182 | (1) |
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183 | (1) |
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9.3 Early, transient, or acute effects of coffee consumption on CVD |
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183 | (2) |
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9.3.1 Tolerance or modification |
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184 | (1) |
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9.4 Coffee metabolism and CVD: genetic influences |
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185 | (1) |
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9.5 Long-term habitual coffee consumption and CVD |
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185 | (4) |
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185 | (1) |
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9.5.1.1 Coffee consumption, blood pressure, and hypertension |
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186 | (1) |
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9.5.1.2 Coffee intake and risk of type 2 diabetes |
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187 | (1) |
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9.5.1.3 Coffee and atherosclerosis |
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188 | (1) |
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9.5.1.4 Coffee consumption and plasma homocysteine |
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188 | (1) |
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9.6 Coffee consumption and heart failure |
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189 | (1) |
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9.7 Coffee consumption and stroke |
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189 | (1) |
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190 | (7) |
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190 | (7) |
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197 | (14) |
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197 | (1) |
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198 | (1) |
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198 | (1) |
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199 | (1) |
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199 | (1) |
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200 | (1) |
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201 | (1) |
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201 | (1) |
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201 | (1) |
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10.10 Head and neck cancers |
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202 | (1) |
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203 | (1) |
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204 | (1) |
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204 | (1) |
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204 | (1) |
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205 | (6) |
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205 | (6) |
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11 Coffee Consumption and Mortality Risk |
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211 | (16) |
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211 | (1) |
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11.2 Coffee consumption and all-cause mortality |
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211 | (10) |
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11.3 Coffee consumption and CVD mortality |
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221 | (1) |
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11.4 Coffee consumption and cancer mortality |
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222 | (1) |
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11.5 Possible mechanism of CVD mortality reduction by coffee |
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223 | (1) |
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223 | (4) |
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224 | (3) |
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12 Is Coffee the Next Red Wine? Coffee Polyphenol and Cholesterol Efflux |
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227 | (6) |
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12.1 High-density lipoprotein and cardiovascular disease |
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227 | (1) |
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12.2 Coffee and cardiovascular disease |
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227 | (1) |
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228 | (1) |
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12.4 Coffee polyphenols and cholesterol efflux |
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229 | (4) |
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230 | (3) |
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13 Additional Positive Impacts on Health |
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233 | (10) |
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13.1 Coffee intake and reduced risk of suicide |
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233 | (2) |
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13.2 Enhanced cognitive performance and mood |
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235 | (1) |
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13.3 Coffee bioactive compounds |
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236 | (7) |
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238 | (5) |
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14 Epidemiological Evidence for Maternal Prenatal Coffee and Caffeine Consumption and Miscarriage Risk |
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243 | (16) |
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243 | (1) |
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14.2 Coffee consumption during pregnancy: a three-decade-old concern |
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243 | (1) |
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14.3 Evidence from the current literature |
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244 | (3) |
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14.4 Methodological concerns and limitations for studies on coffee or caffeine exposure and miscarriage |
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247 | (6) |
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14.4.1 Study design and subject recruitment |
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247 | (1) |
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14.4.2 Exposure assessments |
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247 | (1) |
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14.4.2.1 Quantifying individual caffeine exposure |
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247 | (2) |
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14.4.2.2 Accounting for other sources of caffeine |
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249 | (1) |
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14.4.2.3 Identifying critical timing of exposures |
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249 | (1) |
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14.4.2.4 Maternal, fetal, and placental caffeine metabolism |
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250 | (1) |
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14.4.2.5 Use of self-reporting versus biomarker data |
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251 | (1) |
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14.4.3 Analytical approach: controlling for key confounders |
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251 | (1) |
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14.4.3.1 Confounding by nausea and vomiting in pregnancy |
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251 | (1) |
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14.4.3.2 Confounding by cigarette smoking |
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252 | (1) |
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14.4.4 Determining gestational age, late recognition of fetal demise, and pregnancy outcome assessment |
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252 | (1) |
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14.5 Risk for recurrent miscarriage |
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253 | (1) |
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14.6 Conclusion, public health implications, and recommendations for future studies |
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254 | (5) |
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255 | (4) |
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259 | (16) |
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259 | (1) |
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260 | (1) |
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15.3 Occurrence in coffee and exposure estimates |
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260 | (2) |
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15.4 Mechanisms of formation |
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262 | (2) |
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264 | (4) |
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15.5.1 Agronomical stage (green bean) |
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264 | (1) |
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15.5.2 Processing conditions |
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265 | (1) |
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265 | (1) |
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266 | (1) |
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15.5.2.3 Others (e.g., lactic acid bacteria) |
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267 | (1) |
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15.5.3 Final preparation (brew strength) |
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268 | (1) |
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15.5.4 Storage and shelf-life stability |
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268 | (1) |
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15.6 Risk assessment and risk management |
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268 | (2) |
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270 | (5) |
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271 | (4) |
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16 Impact of Coffee on Gastric Acid Secretion |
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275 | (18) |
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275 | (1) |
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16.2 Regulation of gastric acid secretion |
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276 | (3) |
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16.2.1 Phases of gastric secretion |
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276 | (1) |
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16.2.2 Gastric H, K-ATPase |
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277 | (2) |
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16.3 Effects of coffee on gastric secretion |
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279 | (6) |
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16.3.1 Effects of decaffeinated coffee vs. regular coffee |
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279 | (1) |
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16.3.2 Effects of steam-treated and dewaxed coffee |
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280 | (1) |
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16.3.3 Ulcerogenic effects of coffee beverages and their chemopreventive potential |
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281 | (1) |
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16.3.4 Recent approaches to evaluate the gastric irritation potential of coffee beverages |
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282 | (3) |
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16.4 Optimization of coffee bean processing to reduce the gastric acid stimulatory potential of coffee |
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285 | (1) |
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285 | (1) |
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286 | (1) |
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286 | (1) |
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16.5 Dietary impact on the gastric acid stimulatory potential of coffee |
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286 | (1) |
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287 | (6) |
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287 | (6) |
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17 Potential Mental Risks |
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293 | (14) |
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17.1 Epidemiology of coffee and other forms of caffeine |
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293 | (2) |
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17.2 Beneficial effects of caffeine |
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295 | (1) |
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17.3 Risks associated with caffeine use |
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296 | (5) |
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17.3.1 Acute intoxication |
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296 | (1) |
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17.3.2 Tolerance and physical dependence |
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297 | (1) |
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298 | (1) |
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299 | (1) |
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300 | (1) |
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300 | (1) |
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17.4 Summary and conclusions |
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301 | (6) |
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301 | (6) |
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307 | (12) |
|
|
|
|
|
307 | (1) |
|
18.2 Physical and chemical properties |
|
|
307 | (1) |
|
18.3 Toxicology and risk assessment |
|
|
307 | (2) |
|
18.4 Occurrence of furan in coffee |
|
|
309 | (7) |
|
18.4.1 Mechanisms of furan formation |
|
|
309 | (1) |
|
18.4.2 Furan formation during roasting |
|
|
310 | (1) |
|
18.4.2.1 Green coffee types |
|
|
310 | (1) |
|
18.4.2.2 Roasting conditions |
|
|
310 | (1) |
|
18.4.3 Furan levels in coffee from roasting to cup |
|
|
311 | (1) |
|
|
|
311 | (1) |
|
18.4.3.2 Consumer handling/kitchen life |
|
|
312 | (1) |
|
|
|
313 | (2) |
|
|
|
315 | (1) |
|
18.4.3.5 Cup of coffee as consumed |
|
|
315 | (1) |
|
|
|
316 | (3) |
|
|
|
316 | (3) |
| Index |
|
319 | |