This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.
This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal
Introduction: Glycobiology and diseases. Immunoglobulins, inflammation
and glycosylation. Analytical Techniques for structural Characterization of
Glycosaminoglycan Oligosaccharides. Natural anti-glycan antibodies in
malignancies in normal and aberrant pregnancy. Identifying urinary glycans as
a possible method for the diagnosis of lysosomal storage diseases.
Proteoglycans in health and disease. Glycobiology of Human Milk: Biological
Roles and Diseases. Pectins as biological modulators of human physiological
reactions. Role of glycosylation in TOLL-like receptor activation and
proinflammatory responses. Studying carbohydrate-lectin interactions by
computational approaches. Altered sialylation of glycoproteins and its impact
on disease pathogenesis. Connection between Parkinsons disease and Gaucher
disease.
Gherman Wiederschain, M.D., Ph.D., is Research Associate Professor and Visiting Scholar in the Biology Department at Boston College, Boston, MA, USA.
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