This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.
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1 Introduction to Glycobiology and Human Diseases |
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1 | (27) |
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2 Structural Analysis of Glycosaminoglycans---An Indispensable Tool for the Diagnosis, Treatment and Prevention of Human Disease |
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28 | (37) |
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3 Identifying Urinary Glycans is a Suitable Approach for the Diagnosis of Lysosomal Storage Diseases |
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65 | (21) |
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4 Glycosaminoglycan Binding by the Lyme Disease Spirochete is a Determinant of Tissue Tropism and Disease |
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86 | (11) |
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5 The Role of Viral Envelope Protein Glycosylation in Pathogenesis of Influenza A Virus |
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97 | (12) |
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6 Application of Lectin Histochemistry for the Diagnosis of Lysosomal Storage Diseases |
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109 | (20) |
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7 Computational Approaches for Studying Carbohydrate-Lectin Interactions in Infection |
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129 | (19) |
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8 Altered Sialylation of Glycoproteins and Its Impact on Disease Pathogenesis |
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148 | (17) |
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9 Role of Glycosylation in TOLL-like Receptor Activation and Pro-inflammatory Responses |
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165 | (20) |
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10 Novel Insights on Sialyltransferase Regulators of Cancer-associated O-glycans |
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185 | (17) |
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11 Pectins as Biological Modulators of Human Physiological Reactions |
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202 | (21) |
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12 Glycobiology of Human Milk in Health and Disease |
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223 | (18) |
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13 Molecular Mechanisms Underlying the Association between Gaucher Disease and Parkinson's Disease |
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241 | (9) |
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14 Differential Expression and Function of Linear and Branched Polylactosamine N-linked Glycans in the Nervous System |
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250 | (19) |
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15 Immunoglobulin Glycosylation in Health and Disease |
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269 | (15) |
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16 Congenital Disorders of Glycosylation |
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284 | (29) |
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17 Antibodies to Hyaluronic Acid in Preeclampsia |
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313 | (10) |
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| Index |
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323 | |
Gherman Wiederschain, M.D., Ph.D., is Research Associate Professor and Visiting Scholar in the Biology Department at Boston College, Boston, MA, USA.
