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E-raamat: Hereditary Breast Cancer [Taylor & Francis e-raamat]

Edited by (University of Pennsylvania, Philadelphia, PA, USA), Edited by
  • Formaat: 400 pages
  • Ilmumisaeg: 19-Jun-2019
  • Kirjastus: CRC Press
  • ISBN-13: 9780429116766
  • Taylor & Francis e-raamat
  • Hind: 295,43 €*
  • * hind, mis tagab piiramatu üheaegsete kasutajate arvuga ligipääsu piiramatuks ajaks
  • Tavahind: 422,05 €
  • Säästad 30%
  • Formaat: 400 pages
  • Ilmumisaeg: 19-Jun-2019
  • Kirjastus: CRC Press
  • ISBN-13: 9780429116766
Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.
Foreword iii
Henry T. Lynch
Preface vii
Contributors xi
SECTION 1 OVERVIEW OF HEREDITARY BREAST CANCER
1 The Genetic Epidemiology of Hereditary Breast Cancer
1(18)
Douglas F. Easton
Antonis C. Antoniou
Deborah Thompson
2 Risk Prediction in Breast Cancer
19(16)
Lisa Walker
Rosalind Eeles
3 Bioethics of Genetic Testing for Hereditary Breast Cancer
35(18)
Beth N. Peshkin
Wylie Burke
SECTION 2 HEREDITARY BREAST CANCER SYNDROMES WITH KNOWN GENETIC ETIOLOGIES
4 Cancer Risks in BRCA1 and BRCA2 Mutation Carriers
53(26)
Kenneth Offit
Peter Thorn
5 PTEN and Cowden Syndrome
79(16)
Kevin M. Zbuk
Jennifer Stein
Char is Eng
6 Li-Fraumeni Syndrome
95(16)
Louise C. Strong
7 Rare Causes of Inherited Breast Cancer Susceptibility
111(16)
Katherine L. Nathanson
8 Low-Penetrance Genes in Breast Cancer
127(12)
Paul D. P. Pharoah
SECTION 3 ASSESSMENT AND DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS
9 Biology of BRCA1- and BRCA2-Associated Carcinogenesis
139(14)
Jenny Llamas
Lawrence C. Brody
10 Genetic Testing and Counseling Issues
153(26)
Jill Stopfer
Vickie Venne
Katherine Schneider
11 Molecular Diagnostics: Methods and Limitations
179(28)
Sean V. Tavtigian
Florence LeCalvez-Kelm
12 Breast Cancer Risk Modifiers
207(26)
Roger Milne
Georgia Chenevix-Trench
13 BRCAl and BRCA2 in Underserved and Special Populations
233(22)
Bifeng Zhang
Olufunmilayo I. Olopade
14 Psychological and Behavioral Impact of BRCA1/2 Genetic Testing
255(22)
Kristi Graves
Marc D. Schwartz
SECTION 4 SCREENING AND PREVENTION OF HEREDITARY BREAST CANCER
15 Breast Cancer Screening and Prevention Options in BRCA1 and BRCA2 Mutation Carriers
277(24)
Karen Lisa Smith
Claudine Isaacs
16 Ovarian Cancer Screening and Prevention Options: Ovarian Cancer Screening and Its Limitations. Who Should be Screened?
301(10)
Karen H. Lu
Steven J. Skates
17 Management of BRC4-Negative Hereditary Breast Cancer Families
311(8)
Noah D. Kauff
SECTION 5 CLINICAL MANAGEMENT OF HEREDITARY BREAST CANCER
18 Pathology of Breast Tumors in Hereditary Breast Cancer
319(14)
William D. Foulkes
Lars A. Akslen
19 Pathology of Ovarian Tumors in Mutation Carriers
333(12)
Frederique Penault-Llorca
Sunil R. Lakhani
20 Local Treatment Issues in Women with Hereditary Breast Cancer
345(16)
Merav A. Ben-David
Lori J. Pierce
21 Systemic Therapy for BRC4-Associated Breast Cancer
361(16)
Mark Robson
Index 377
Claudine Isaacs, Timothy R. Rebbeck