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E-raamat: Hereditary Breast Cancer

Edited by , Edited by (University of Pennsylvania, Philadelphia, PA, USA)
  • Formaat: PDF+DRM
  • Ilmumisaeg: 19-Sep-2007
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781420020366
  • Formaat - PDF+DRM
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  • Formaat: PDF+DRM
  • Ilmumisaeg: 19-Sep-2007
  • Kirjastus: CRC Press Inc
  • Keel: eng
  • ISBN-13: 9781420020366

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Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this
source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.
Foreword iii
Henry T. Lynch
Preface vii
Contributors xi
SECTION 1: OVERVIEW OF HEREDITARY BREAST CANCER
The Genetic Epidemiology of Hereditary Breast Cancer
1(18)
Douglas F. Easton
Antonis C. Antoniou
Deborah Thompson
Risk Prediction in Breast Cancer
19(16)
Lisa Walker
Rosalind Eeles
Bioethics of Genetic Testing for Hereditary Breast Cancer
35(18)
Beth N. Peshkin
Wylie Burke
SECTION 2: HEREDITARY BREAST CANCER SYNDROMES WITH KNOWN GENETIC ETIOLOGIES
Cancer Risks in BRCA1 and BRCA2 Mutation Carriers
53(26)
Kenneth Offit
Peter Thom
PTEN and Cowden Syndrome
79(16)
Kevin M. Zbuk
Jennifer Stein
Charis Eng
Li--Fraumeni Syndrome
95(16)
Louise C. Strong
Rare Causes of Inherited Breast Cancer Susceptibility
111(16)
Katherine L. Nathanson
Low-Penetrance Genes in Breast Cancer
127(12)
Paul D. P. Pharoah
SECTION 3: ASSESSMENT AND DISSEMINATION OF CLINICAL RISKS FOR BRCA1/2 MUTATION CARRIERS
Biology of BRCA1- and BRCA2-Associated Carcinogenesis
139(14)
Jenny Llamas
Lawrence C. Brody
Genetic Testing and Counseling Issues
153(26)
Jill Stopfer
Vickie Venne
Katherine Schneider
Molecular Diagnostics: Methods and Limitations
179(28)
Sean V. Tavtigian
Florence LeCalvez-Kelm
Breast Cancer Risk Modifiers
207(26)
Roger Milne
Georgia Chenevix-Trench
BRCA1 and BRCA2 in Underserved and Special Populations
233(22)
Bifeng Zhang
Olufunmilayo I. Olopade
Psychological and Behavioral Impact of BRCA1/2 Genetic Testing
255(22)
Kristi Graves
Marc D. Schwartz
SECTION 4: SCREENING AND PREVENTION OF HEREDITARY BREAST CANCER
Breast Cancer Screening and Prevention Options in BRCA1 and BRCA2 Mutation Carriers
277(24)
Karen Lisa Smith
Claudine Isaacs
Ovarian Cancer Screening and Prevention Options: Ovarian Cancer Screening and Its Limitations. Who Should be Screened?
301(10)
Karen H. Lu
Steven J. Skates
Management of BRCA-Negative Hereditary Breast Cancer Families
311(8)
Noah D. Kauff
SECTION 5: CLINICAL MANAGEMENT OF HEREDITARY BREAST CANCER
Pathology of Breast Tumors in Hereditary Breast Cancer
319(14)
William D. Foulkes
Lars A. Akslen
Pathology of Ovarian Tumors in Mutation Carriers
333(12)
Frederique Penault-Llorca
Sunil R. Lakhani
Local Treatment Issues in Women with Hereditary Breast Cancer
345(16)
Merav A. Ben-David
Lori J. Pierce
Systemic Therapy for BRCA-Associated Breast Cancer
361(16)
Mark Robson
Index 377


Claudine Isaacs, Timothy R. Rebbeck
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