Overview on Opioid-Induced Hyperalgesia. Cellular Mechanisms Underlying Morphine Analgesic Tolerance and Hyperalgesia. Overview on Clinical Features of Opioid-Induced Hyperalgesia. Clinical Assessment Tools: Quantitative Sensory Testing. Opioid Tolerance, Dependence, and Hyperalgesia. Challenging Clinical Issues on the Interaction Between Addiction and Hyperalgesia. Practical Management of Opioid-Induced Hyperalgesia in the Primary Care Setting. Managing Opioid-Induced Hyperalgesia in the Perioperative Period. Role of Ketamine in Managing Opioid-InducedHyperalgesia. Role of Opioid Rotation and Tapering in Managing Opioid-Induced Hyperalgesia. Clinical Implications of Opioid-Induced Hyperalgesia.