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E-raamat: Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants [Taylor & Francis e-raamat]

Edited by (University of Southern California, Los Angeles, USA)
  • Formaat: 384 pages
  • Ilmumisaeg: 19-Sep-2019
  • Kirjastus: CRC Press
  • ISBN-13: 9780429180453
  • Taylor & Francis e-raamat
  • Hind: 401,61 €*
  • * hind, mis tagab piiramatu üheaegsete kasutajate arvuga ligipääsu piiramatuks ajaks
  • Tavahind: 573,72 €
  • Säästad 30%
  • Formaat: 384 pages
  • Ilmumisaeg: 19-Sep-2019
  • Kirjastus: CRC Press
  • ISBN-13: 9780429180453
This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area.
Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants!
Featuring the research of over 55 experts in the area, Understanding the Process of Aging
  • covers the functions of nitric oxide and peroxynitrite in mitochondria
  • integrates several views on the role of mitochondria in the development of apoptosis
  • gives a quantitative analysis of mutations of mitochondrial DNA during human aging
  • highlights mitochondrial free radical production
  • introduces new roles of ubiquinone in mitochondrial functions
  • offers new antioxidant-based complementary therapeutic strategies
  • details aspects of intact cells and whole organisms in health and disease
  • and more!
    Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
  • Series Introduction (Lester Packer and Enrique Cadenas) iii
    Preface vii
    Contributors xi
    1 The Mitochondrial Production of Oxygen Radicals and Cellular Aging
    1(16)
    Alberto Boveris
    Lidia E. Costa
    Enrique Cadenas
    2 Walking a Tightrope: The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion
    17(22)
    David M. Guidot
    Joe M. McCord
    3 The Biochemistry of Nitric Oxide and Peroxynitrite: Implications for Mitochondrial Function
    39(18)
    Rakesh P. Patel
    Trudy Comwell
    Victor M. Darley-Usmar
    4 Oxygen-Dependent Regulation of Biological Functions by Nitric Oxide
    57(16)
    Kozo Utsumi
    Yoshiki Takehara
    Yoko Inai
    Munehisa Yabuki
    Tomoko Kanno
    Manabu Nishikawa
    Eisuke F. Sato
    Masayasu Inoue
    5 Production of Reactive Oxygen Species in Mitochondria and Age-Associated Pathophysiology: A Reality Check
    73(22)
    Henry Jay Forman
    Angelo Azzi
    6 Functional Roles of Ubiquinone
    95(24)
    Jeffery R. Schultz
    Catherine Freitag Clarke
    7 Mitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging: Roles of Coenzyme Q and Tocopherol
    119(24)
    Rajindar S. Sohal
    Achim Lass
    Liang-Jun Yan
    Linda K. Kwong
    8 Mitochondria and Aging: The Mouse's Tale
    143(24)
    Steve Esworthy
    9 Mitochondria and Apoptosis
    167(14)
    Bernard M. Babior
    Roberta A. Gottlieb
    Christoph Richter
    10 Role of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis: Studies in Intact Cells
    181(22)
    Juan Sastre
    Federico V. Pallardo
    Jose Garcia de la Asuncion
    Miguel A. Asensi
    Juan M. Esteve
    Jose Vina-Ribes
    11 The Role of Iron and Mitochondria in Aging
    203(26)
    Patrick B. Walter
    Kenneth B. Beckman
    Bruce N. Ames
    12 The Mitochondrial-Lysosomal Axis Theory of Cellular Aging
    229(22)
    Ulf T. Brunk
    Alexei Terman
    13 Quantitative Analysis of Mutations of Mitochondrial DNA During Human Aging
    251(14)
    Jorg Napiwotzki
    Annette Reith
    Andreas Becker
    Sandra Leist
    Bernhard Kadenbach
    14 Oxidative Damage and Fragility of Mitochondrial DNA
    265(28)
    Takayuki Ozawa
    15 Mitochondria in Cellular Aging and Degeneration
    293(18)
    Gino A. Cortopassi
    Alice Wong
    16 Mitochondrial Alteration in Aging and Inflammation: A Possible Site of Action of Nitrone-Based Free Radical Traps
    311(16)
    Kenneth Hensley
    Lindsay Maidt
    C. A. Stewart
    Quentin N. Pye
    K. A. Robinson
    Robert A. Floyd
    17 Muscle Mitochondrial Transmembrane Processes in Mitochondriocytopathies
    327(34)
    Marjan Huizing
    J. M. F. Trijbels
    J. A. M. Smeitink
    L. P. van den Heuvel
    Fernando Palmieri
    Wim Ruitenbeek
    Index 361
    Enrique Cadenas, Lester Packer